After doing lots of experimentation and research I started to develop a sixth sense – namely, detecting bullsh*t claims by companies. Take a look at this supplement called Prevagen.
The studies that were done were terrible and I had no faith it would work. But I did get a free bottle that I ordered a year and a half ago and that I had never used. So I figured I should try it out.
For one, they mention the effects take time. Never a good sign. If something works you should feel it right away (within 45 min).
Second, they don’t provide the full studies on their site (at least it isn’t easy to find). If you look at what they do provide you see the results are clinically insignificant. What I see are graphs that are made to look significant but aren’t.
The nicely designed site and an entertaining video with no information didn’t help the matter. It seemed like this was all marketing.
Assumptions Made by Company
1) That a protein is taken orally can get into and affect the brain. Proteins are digested in the stomach and intestines, so it’s likely this wouldn’t even get into the bloodstream untarnished, if at all.
2) If it was able to get into the bloodstream intact, it probably wouldn’t be able to cross the blood-brain barrier, especially proteins. This is why they had to drill a hole in a rat’s skull and stick a microinjection needle in its brain to put the prevalence in there and get any kind of result in the rat study. The stuff is not getting into the brain of a living creature through any other route than the hole in skull/needle in brain route.
3) Even if it overcame these obstacles, aequorin is involved in calcium signaling inside the cell. in order to use aequorin in scientific applications relating to calcium signaling, it needs to be microinjected into the cell, because as you might imagine, a large protein molecule cannot cross a cell membrane either.
My Experiment and Results
I figured if this was to have any effect I’d need to take a large dose. I looked at the safety data and there was a huge margin for error, so I decided to take most of the bottle in one shot.
The suggested serving size is 1 capsule and it comes with 30 capsules. I took 20 capsules. I would’ve taken the whole bottle but I was more concerned with the excipients, like rice flour.
There was really no point in even experimenting but I wanted the empty capsules and I figured why not…I assumed there may have been some tiny chance that I would notice something…
Result: The only effect I noticed was slight fatigue, but that could’ve been because I had 4 hours of sleep the night before. Otherwise, I didn’t feel anything.
What I’ve learned in life is never to buy anything with extensive marketing – in any sphere.
Products with marketing are going to cost 5X the amount with less efficacy. I’ve always found cheaper, more effective products that offered similar results without the accompanied marketing.