16 Health Benefits of The “Anti-Nutrient” Phytic Acid

(arrow pointing to a mineral means it competes against it.)

Introduction to Phytic Acid


Phytic acid aka phytate is found in whole grains, legumes, potatoes, nuts, and seeds.   It is demonized in the paleo movement as an anti-nutrient, from which we should stay away.

The reason it’s referred to as such is because it binds minerals such as calcium, iron, potassium, magnesium, manganese and zinc, copper and selenium, therefore, supposedly making them insoluble and thus unavailable for absorption in the intestinal tract of humans.

The picture isn’t so clear, however, and phytate also has a number of health benefits.  This post is meant to demonstrate the phytic acid isn’t the villain it’s portrayed to be and is instead on the whole more healthful than not.

I don’t advocate supplementing with phytic acid since there’s an abundant supply of starches and plant foods (on a lectin avoidance diet, phytate is mostly removed).

Phytate is capable of being absorbed in our GI tract (R).

Note that phytic acid, phytate, PA, inositol hexaphosphate and IP6 all refer to the same compound.

Possible Drawbacks

Before I speak about the benefits, I’d like to mention some drawbacks.

Phytate has been shown to inhibit digestive enzymes such as trypsin, pepsin, α-amylase, and ß-glucosidase. (R) Alpha-amylase inhibition is used by diabetics to slow glucose absorption, so that’s actually not bad.

Phytic acid in excess is said to cause some GI issues, but I haven’t found scientific evidence of this.  There were no harmful GI effects in mice fed significant quantities of phytate. (R)  I believe that the GI irritation from foods with phytate is actually coming from dietary lectins.

When I took phytase to break down phytic acid I didn’t notice a difference with regard to inflammation from food.  However, when I took sugars that bind to lectins I did notice a significant difference.  This is one way I realized that phytic acid wasn’t the main culprit for me, but rather lectins were.   I’ve also consumed phytate supplements, without any ill effects.

Phytate can bind to certain minerals, which I discuss below, but for the most part, it’s not an issue.    The main mineral that you should be concerned with is Zinc, which is why you should supplement with it if you have a plant-based diet.

1) Phytic Acid is an Anti-oxidant.


Phytic acid has protected against alcohol-related liver injury by blocking free radicals and elevating antioxidant potentials. (R)

The anti-oxidative action of phytic acid is as a result of inhibiting Xanthine Oxidase and by ‘preventing a formation of ADP-iron-oxygen complexes’ (R).  It was also able to protect DNA from free radicals. (R)

Roasting/cooking foods with phytic acid improved antioxidant ability. (R)

2) Phytic Acid Reduces Inflammation.

Phytic acid was found to decrease the inflammatory cytokines IL-8  and IL-6, especially in colon cells (R, R2).

3) Phytic Acid Induces Autophagy

Phytic Acid was found to induce autophagy (R).

Autophagy is a physiological process for degrading and recycling junk proteins. (R)

 It has recently been recognized as a principal response to cellular stress and an important regulator of neuronal function and survival. (R)

It plays a role in the destruction of pathogens inside our cells and aids the cell in eliminating pathogens. (R)

As a ‘quality control’ process, autophagy is believed to be particularly beneficial in neurodegenerative disorders – Alzheimer’s, Parkinson’s, ALS and Huntington’s.   This is because these disorders are, in part, characterized by the accumulation of misfolded disease-causing proteins. (R)

Research suggests that autophagy is required for the lifespan-prolonging effects of caloric restriction (R) and for much of the health benefits of exercise (R).  Inhibiting mTOR increases autophagy, which is part of the reason mTOR inhibition increases longevity. (R)

4) Phytic Acid Has Potential For Treating Multiple Cancers


Phytic acid was found to be anti-cancer against bone, prostate, ovarian, breast, liver, colorectal, leukemia, sarcomas and skin cancers (RR2R3, R4, R5, R6)

Mechanism: suppressing the expression of MMPs (R) and telomerase. (R)

5) Phytic Acid Benefits Blood Glucose Control

Studies show that phytate reduces blood glucose levels in mice and rats (RR2R3).

It works in part by slowing the rate of starch digestibility (R).  

6) Phytic Acid is Neuroprotective


Neuroprotective effects of Phytic acid were found in a cell culture model of Parkinson’s disease (R).

It was found to protect against 6-Hydroxydopamine-Induced dopaminergic neuron apoptosis, which causes Parkinson’s (R).

By inducing autophagy, it can also protect against Alzheimer’s (R) and other neurodegenerative diseases

7) Phytic Acid Reduces Triglycerides and Increases HDL

Studies have found phytate reduces triglycerides and increases HDL cholesterol (the good one) in rats. (R)

8) Phytic Acid  Repairs DNA


It was found that phytic acid can enter cells and help DNA repairs breaks in the strands.  This is a potential mechanism by which phytate prevents cancer. (R)

9) Phytic Acid Increases Bone Mineral Density

Phytate consumption had a protective effect against osteoporosis.  Low phytate consumption is a risk factor for osteoporosis. (R)

Adequate consumption of phytate may play an important role in the prevention of bone mineral density loss in postmenopausal women (R).

10) Phytic acid protects human skin from UVB exposure


UVB radiation damages skin cells, which can cause skin damage, cancer and suppression of the immune system. (R)

Studies show that phytic acid protects cells from UVB-induced destruction and mice from UVB-induced tumors. (R)

11) Phytic Acid Can Protect The Gut From Toxins

Phytic acid supplementation increased gut transit time and resulted in more efficient absorption of nutrients (via ‘surface amplification’). (R)

Phytate also protects intestinal cells from certain toxins – at least in pigs (R).

12) Phytic Acid Helps Prevent Kidney Stones

In rats treated with phytic acid, calcifications in their kidneys were reduced, which suggests potential for preventing kidney stones. (R)

In another animal study found that it inhibited the formation of calcium oxalate stones. (R)

In a study on humans, phytate urinary levels in a group of active calcium oxalate stone formers were studied and compared with those found in healthy people. Urinary phytate was significantly lower for stone formers. (R)

Low phytate levels may be why kidney stones are more of a problem in the paleo world.

13) Phytic acid binds to Heavy Metals, Mycotoxins, Uranium, Iron, Manganese   

Phytic acid is one of few chelating therapies used for uranium removal (R).

Phytic Acid  reduces  the toxicity of mycotoxins, which may be explained by its antioxidant activity (R).

It also binds to heavy metals, iron, and manganese.  Iron and manganese are nutrients that we normally get too much of, but not always.  If we do have an excess, then that can have ill effects on our health.

14) Phytic Acid Decreases Uric Acid/Helps Gout

By inhibiting the enzyme xanthine oxidase, phytic acid blocks the buildup of uric acid and can help prevent gout (R).

15) Phytic Acid is Anti-HIV

Phytate was able to inhibit the replication of HIV-1 in cell lines. PA was only beneficial on an early replicative stage of HIV-1. (R)

16) Phytic Acid Increases The Bioavailability of Flavones

Phytate is a potential absorption enhancer for pharmaceuticals/supplements.

The oral bioavailability of isorhamnetin, kaempferol, and quercetin  was enhanced by the co-administration of Phytate.

The main mechanisms are related to their enhanced aqueous solubility and permeability in the presence of phytate.  (R)

How Phytate Interacts With Minerals

There’s really only a few minerals that phytate binds to and as a result of the binding may potentially lead to health problems.

The minerals you should pay attention to are Zinc and to a lesser extent calcium and chromium.


Phytic acid can bind to zinc somewhat strongly and can cause GI problems, among other health issues.  Zinc binding I think is the biggest issue and most people eating a plant based diet should supplement with a small amount of zinc.  Not only is phytate a problem because of zinc binding, but since eating such a diet contains a lot of copper, it will interfere further with zinc absorption. For these reasons, I supplement with 15mg of zinc glycinate and recommend this dosage to others, especially men.   Women need less zinc, so it’s less likely to as big of a problem for them (RDA for men 19+ yrs old is 11mg and 8mg for women).  10mg of supplemental zinc should suffice for women.


Phytate can also bind to calcium, albeit not as strongly as it binds to zinc.  But not only have I not seen health problems as a result of this binding to calcium, I’ve only seen studies where it increases bone mineral density, which is unexpected.   We obviously don’t have the full story. My wild guess is that it mainly binds to extra calcium that the body isn’t using and helps utilize or retain the rest of the calcium in some fashion.  I supplement with 250mg 2X a day, not so much because of the phytic acid, but more because I don’t eat dairy and I don’t get the recommended level of calcium.  If I did eat dairy, I’d consume maybe 150mg of calcium just to be safe (the RDA is 1000mg), because after all phytic acid does bind to calcium. Linus Pauling institute: “Phytic acid is a less potent inhibitor of calcium absorption than oxalate. Only concentrated sources of phytate, such as wheat bran or dried beans, substantially reduce calcium absorption.”  So, I think people should focus on getting the RDA for calcium and maybe take a bit more if you consume a lot of phytates – just in case.


Binding of phytic acid to magnesium is not a good thing, but the foods with phytic acid are also usually rich in magnesium.


I’ve also seen a study where it binds to chromium and I was deficient in chromium at one point, so that may be a problem, too.  Chromium deficiency is supposedly rare, but my experience possibly suggests otherwise, since I was eating a whole food diet with no added sugar (sugar causes an excretion of chromium).  It could be that I was deficient in chromium not because of phytic acid but because of decreased gut function from ingesting gluten or from a zinc deficiency.  I take 100mcg of chromium GTF every day. These interventions are extremely cheap, simple and safe, so I find the drawbacks of consuming phytic acid to be very minimal.


Most people actually have too much iron.  I’ve experimented with a starch based diet for a while and my iron levels were still higher than the ideal range for anti-aging purposes, and that was without eating red meat.  In addition, I also drank tea, kombucha, curcumin and a bunch of other iron chelators. Iron is in all foods and deficiency is usually caused by something else other than low consumption of iron.  This is the reason you see  some people donating blood to get rid of excess iron.

Menstruating women should monitor their iron levels more closely, however.  I should also mention that people have different genetics with regard to how well they retain iron and I might be -genetically -a  good iron storer.


Selenium is an important mineral that I supplement with since it’s good for autoimmune conditions of the thyroid.  I take 100mcg daily, which is a conservative dosage.  I also make sure not to eat brazil nuts or else I may be getting too much of it.   Phytate doesn’t seem to be an issue for selenium, at least according to this study on baby chicks. If anything it seems to be a benefit.  A quote:

“Phytate increased selenium in all tissues except muscle; it is not clear if this resulted from increased absorption or increased retention.”


The fact the phytate binds to manganese is a plus since people get too much manganese in a starch based diet.


Copper absorption is actually enhanced by phytic acid in copper deficient diets.  I don’t know what would happen in diets that weren’t deficient in copper.  I’d actually rather it bind to copper because starch based diets are too high in copper.  In any case, zinc supplementation should reduce copper absorption, so no worries here.

In Conclusion

If you adopt a plant-based omnivorous diet you likely won’t have a problem, except for zinc.  If you want to be safe you can take a small amount of chromium and calcium, though there’s no evidence that it’s necessary if you consume dairy and a balanced diet.  This is a very small price to pay to get the health benefits of phytate. A review article on phytate and minerals in a vegetarian diet (not a diet I support):

Despite the apparent lower bioavailability of zinc, copper, manganese, and selenium in vegetarian diets because of the high contents of phytic acid and/or dietary fiber and the low content of flesh foods in the diet, the trace element status of most adult vegetarians appears to be adequate. Children, however, appear to be more vulnerable to suboptimal zinc status, presumably because of their high zinc requirements for growth and their bodies’ failure to adapt to a vegetarian diet by increased absorption of dietary zinc (R).


  1. Thank you. Another thing I just learned as I was researching this is that mice and other rodents produce an enzyme called phytase, which digests phytic acid and releases the phosporous. For that reason, “Data from experiments on phytic acid using mice and other rodents cannot be applied to humans.” This might apply to the study related to copper absorption. The reference for the quote can be found here: http://testingcancer.blogspot.com/2015/04/phytic-acid-can-bind-your-minerals.html

    This is so obscure that I think it even had the scientists fooled. The phytic acid probably wasn’t binding with zinc if it was being digested.

    By the way, these comments are delete-able, from my point of view, if the content is corrected.

  2. Shaun

    Thank you for this great analysis. I have got some ideas based on my own research but this article tops what I have found out and make the whole thing come together to build a solid and logical conclusion.

    Great article and nice that you made the time to share this with others.

    Thank you

    • Joseph M. Cohen

      The studies I referenced:

      “Multivariate linear regression analysis indicated that body weight and low phytate consumption were the risk factors with greatest influence on bone mineral density. Phytate consumption had a protective effect against osteoporosis, suggesting that low phytate consumption should be considered an osteoporosis risk factor.”

      The results obtained seem to indicate that the adequate consumption of phytate may play an important role in the prevention of bone mineral density loss in postmenopausal women.”

      Phytase increased BMD in rats fed low zinc and high phytic acid diets….”We conclude that consuming supplemental dietary phytase or dietary Zn additively enhances Zn status to increase BMD, LBM and voluntary physical activity in rats fed a low-Zn diet. ”

      Where did I incorrectly cite a study? Please bring my exact quote, so I can look it up in the post.

  3. Kieron

    Dear Joe What About all of the bad effects Phytic acid has on teeth, One man wrote a whole book on the subject should I get rid of pyhic What should I do?

  4. Dark Circles

    Thank you so much for this very informative post about Phytic Acid. I have heard the name before but I am not familiar about this so much. After reading this article, I know a lot now, and I can share them with others as well.

Leave a Reply