In 1904, Havelock Ellis found in his “A Study of British Genius” that there was an unusually high rate of gout among eminent men in his study. Gout is associated with higher volumes of uric acid (or urate) in the blood. He, therefore, suggested that it might have something to do with it. (R)
Later investigators have examined this relationship, and there is indeed a correlation. A review found only a slight correlation between IQ and uric acid. However, there was a stronger correlation between uric acid and scholastic achievement, even after controlling for IQ. (R)
Another study found a correlation (+.37) between uric acid and publication rates of university professors. This is extremely significant for just one measure tested. Insane. (R)
Uric acid has a similar chemical structure to that of caffeine, and can maybe act as a natural stimulant. (R)
Other Benefits of Uric Acid
Uric acid levels correlate with longevity in monkeys and animals. This is presumably because of urate’s antioxidant properties. (R)
Uric acid levels are much lower in people with Multiple Sclerosis (MS) and a study with 11 people found correcting these levels are therapeutic. (R)
In fact, it prevented the progression of MS in all 11 patients tested and even improved the symptoms of some patients. (R)
Like MS, low uric acid also correlates with Parkinson’s, Alzheimer’s and Huntington’s. (R, R2) Clinical trials are underway to determine if raising urate levels will slow the disease in people. Animal models have
As a natural antioxidant, urate provides up to 60% of the antioxidant capacity in human blood. It also provides protection from the free radicals that it doesn’t neutralize. (R)
However, recent studies indicate that these mechanisms couldn’t explain all of its beneficial effects in the brain. (R)
Studies have found that urate was neuroprotective by protecting neurons from glutamate-induced toxicity, a central cause of neuron degeneration. (R)
In mice with autoimmune conditions, urate was beneficial and increased the survival rate. (R)
Too high or too low levels of uric acid are not good. Too low leads to oxidative stress, but too high can also lead to inflammation, gout and kidney stones. (R)
This is why it’s important to measure your Uric acid levels before you embark on a journey to increase it.
How too much uric acid causes inflammation:
How to Increase Uric Acid
Dairy and maybe calcium lower uric acid levels, which explains why vegans have higher levels than omnivores. Soy might also increase urate levels. (R)
Inosine, found in liver and fish, is the most powerful way to increase uric acid levels. (R) This is what’s used in studies with MS and Parkinson’s.
Inosine increases RNA and DNA production and blood oxygen carrying capacity, which preserves ATP levels.
In a clinical trial with MS patients, Inosine more than doubled uric acid levels (increased from 3.9 to 8.3).
It decreased Nitrotyrosine,a marker of cell damage and inflammation, by more than half (from 73 to 32). (R)
My Experience With Inosine: It’s Amazing
For my first dosage, I took 3 grams in one shot, as an experimental dosage.
For me, it certainly increases cognitive performance and is wakeful promoting. It works.
However, it also caused some slight pain in random places, one of which was my kidneys. Kidney stone formation is very common with inosine supplementation.
I’m still going to include 500mg 1X a day and see how that works in the long term.
There are some negatives to uric acid/inosine such as gout and kidney stones, so be careful. In studies with MS and Parkinson’s, kidney stones were quite common from inosine treatment (up to 1/4 people got it).
However, in the studies that were in a controlled environment, the patients were properly hydrated and none of them got kidney stones. (R)
You need to drink a ton of water (over a gallon) and take potassium citrate to prevent kidney stones.
Uric acid is also capable of binding iron (R), so be careful if you’re anemic.
If you need to supplement with calcium because you’re not getting enough from your diet, it’s better to use the citrate form. I also recommend magnesium citrate.
I’m still taking a risk, but I like the effect enough that it’s worth it for me.
- Inosine (400g) or Inosine (IHERB) or Inosine (eBay)
- Potassium citrate (AMZN) or Potassium Citrate (eBay)
Uric Acid on SelfDecode
- Inosine increases the body's ability to handle rigorous exercise without inducing fatigue and without stimulants.
- Ultimate Nutrition's Premium Inosine supports the body in production of short bursts of energy
- Promotes production of ATP
- Each capsule contains 500 mg. of inosine (hypoxanthine riboside).
- Ecological Formulas / Cardiovascular Research - Inosine 60 capsules