PGC-1a is critical to proper mitochondrial function. If you’ve got mitochondrial problems, this post is a must.
If you want to interpret your genes, you should use SelfDecode.
Do You Have Low PGC-1a?
If you answer yes to these, then that may indicate low PGC-1a:
- Do you get tired often?
- Do you have a low metabolism?
- Do you lack energy in the day?
- Do you have a disturbed circadian rhythm?
- Do you have chronic inflammation?
PGC-1a is one of the most important factors in controlling mitochondrial health. It’s also important for circadian rhythms, energy metabolism, fat metabolism, weight loss, blood pressure, cholesterol homoeostasis and indirectly can help detoxing and drug metabolism.
Intro to PGC-1a
PGC-1a is one of the most important factors in controlling mitochondrial health. PGC-1α makes new mitochondria and improves its function.
PGC-1α increases energy metabolism and weight loss.
PGC-1a protects against neurodegenerative diseases.
Mice lacking PGC-1 alpha show abnormal circadian rhythms, body temperature, and metabolic rate (R).
How to Increase PGC-1a
- Hydroxytyrosol (R)
- Resveratrol (R)
- Nicotinamide Riboside (R)
- EGCG/Tea (R)
- Red yeast rice (R)
- Gotu Kola (R)
- Grape Seed Extract (R)
- R-Lipoic Acid (R)
- Epimedium (R) and Icariin (R)
- Carnitine (R)
- Rhodiola/Salidrosides (R)
- Aspirin (R)
- Quercetin (R)
- Forskolin/Cyclic AMP (R)
I’ve already discussed some common pathways to activate PGC-1a. This means that if you activate these, it will help activate PGC-1a.
What Decreases PGC-1a and Its Activity
- Bile (R)