- The Best Bacopa to Take
- 1) Bacopa is an Antioxidant
- 2) Bacopa is an Anti-Inflammatory
- 3) Bacopa Reduces Stress/Anxiety
- 4) Bacopa Enhances Memory
- 5) Bacopa May Prevent Heart Disease
- 6) Bacopa Protects the Brain
- 14) Bacopa Balances The Immune System
- 15) Bacopa is an Anti-Diabetic
- 16) Bacopa is Antimicrobial
- 17) Bacopa May Help Prevent Cancer
- 18) Bacopa Promotes Longevity
- 19) Bacopa Helps Protect the Gut
- 20) Bacopa has an Antifatigue effect
- 21) Bacopa is a Mild Sedative
- 22) Bacopa Protects the Liver
- 23) Bacopa May Help Muscles
- 24) Bacopa Promotes Hair Growth
- 25) Bacopa Relieves Pain and Fever
- 26-28) Bacopa Helps With Histamine Intolerance, Respiratory Problems and Allergies
- 29) Bacopa Protects Against Cigarette Smoke Damage
- 30) Bacopa Protects the Kidney and is a Diuretic
- 31) Bacopa is Good For Skin Health
- 32) Bacopa may Reduce Morphine Dependence
- 33) Bacopa Increases Thyroid Hormones
- 36) Bacopa is Effective for Snake Bite
- Active Chemical Constituents
- Molecular Targets
- Buying & Dosage
Bacopa monnieri was initially described around the 6th century A.D. in texts such as the Charaka Samhita, Atharva-Veda, and Susrut Samhita as a “Medhya rasayana”–class herb taken to sharpen intellect and attenuate mental deficits (R). The herb was allegedly used by ancient Vedic scholars to memorize lengthy sacred hymns and scriptures (R).
Note: Most of the benefits listed for Bacopa here are studied in animals (as is most herbs) and not humans. However, there has been a long history of its usage in people, with many positive effects. There’s also many positive anecdotes online. I personally have good experience with it as well, which is worth more than any clinical trial in people (for me). The point isn’t to show that Bacopa helps with all of these conditions in humans – it may not. But there’s a chance it does and people must make their own judgement call if they want to “Selfhack”, like I did. The take away here is that Bacopa may have many great effects, and people need to try it out for themselves and see how it helps YOU. This advice goes for all of my supplement articles.
The Best Bacopa to Take
1) Bacopa is an Antioxidant
Bacopa is said to have a significant superoxide radical scavenging activity (R).
Bacopa had a significant protective effect on H2O2 induced DNA damage in human fibroblasts (R).
2) Bacopa is an Anti-Inflammatory
3) Bacopa Reduces Stress/Anxiety
Bacopa reduced retrograde amnesia produced by immobilization induced stress in healthy humans (R).
Bacopa is an effective anti-stress agent against acute and chronic stress in rats (R).
Bacopa extracts can be used as a potent therapeutic agent in treating mixed anxiety-depressive disorder (MAD) in mice (R).
Bacopa showed antidepressant activity when tested on forced swimming and tail suspension in mice (R).
4) Bacopa Enhances Memory
Bacopa is traditionally used for enhancing learning and memory (R).
Bacopa extract had positive effects on learning and memory following 12 weeks administration (R).
Another study showed memory enhancing effects following 4 weeks (R).
An Australian survey showed Bacopa to be one of the most popular aid for memory among 60-64 year old consumers (R).
Bacopa showed a significant effect on retention of new information and also decreased the rate of forgetting newly acquired information in humans (R).
Bacopa has memory- and learning-enhancing effects on long-term dosing in patients with anxiety neurosis (R).
Bacopa was effective against the scopolamine-induced impairment of spatial memory in mice (R).
Bacopa reversed diazepam-induced amnesia in mice (R).
Bacopa reduced the effect of L-NNA induced amnesia in mice (R).
5) Bacopa May Prevent Heart Disease
Bacopa (as a component of Protandim) decreases abnormal growth of normal cells (hyperplasia) in human sephanous veins which are widely used for bypass grafts (R).
Bacopa extract was able to dissolve clots in experimental organisms, hence could be a promising “thrombolytic agent” (R).
Bacopa is a component of a herbal formulation (DHC-1) which had a protective effect against damaged heart in rats (R).
Bacopa (Brahmi) could be an effective antihypertensive and vasodilator in various artery types (R).
6) Bacopa Protects the Brain
Bacopa is known as an effective “brain food” as it nourishes the brain and improves intelligence and memory (R).
Bacopa (Bacosides) is effective against age related chronic neuroinflammation in the rat brain (R).
Bacopa (Bacosides) aids in repair of damaged neurons (R).
Bacopa exerts a protective effect against DNA damage in astrocytes (a star shaped glial cell of the CNS) (R).
Bacopa enhanced protein kinase activity and increased protein in the hippocampus of humans (R).
7-9) Bacopa May Help Neurodegenerative Conditions: Huntington’s, Parkinson’s and Alzheimer’s
Bacopa is said to be a promising anti-Huntington neuroprotective agent (R).
Bacopa is a potential anti-Parkinsonian agent (reduces alpha synuclein aggregation, prevents dopaminergic neurodegeneration and restores the lipid content in nematodes) (R).
Bacopa can protect cells through modulating cellular redox pathways which are altered in Parkinsons Disease (PD) (R).
Alcoholic extract of Bacopa might be helpful in reducing 6-OHDA (6-HydroxyDopamine) induced lesioning in Parkinsonian rat models (R).
10-11) Bacopa Improves ADHD and Dyslexia
Bacopa is effective in the management of Dyslexia (reading disorder) in children (R).
12) Bacopa May Help Cognitive Decline in Schizophrenia
Bacopa has the ability to reduce Nitric Oxide-induced cellular alterations in neurological disorders (R).
Bacopa enhances kinase activity, neuronal sythesis, restoration of synaptic activity and nerve impulse transmission (R).
13) Bacopa For Bronchitis/Asthma
A hot soft moist mass of Bacopa is applied for Bronchitis and chest ailments in children (R).
14) Bacopa Balances The Immune System
Bacopa is effective in managing diseases involving chronic brain inflammation driven by the innate immune system (R).
Bacopa is used to treat enlargement of spleen (R).
Bacopa (Brahmi) reversed the age-related increase in lipid peroxidation in the spleen cells of both early-middle-aged and old rats (R).
15) Bacopa is an Anti-Diabetic
16) Bacopa is Antimicrobial
Bacopa showed antimicrobial activity against Vibrio cholera (R).
Alcoholic leaf extract of Bacopa exhibited antibacterial activity against Pseudomonas aeruginosa, Klebsiella pneumonia and E.coli (R).
Alcoholic (diethyl ether) extract of Bacopa had maximum inhibitory effect against Staphylococcus aureus and Proteus vulgaris (R).
Bacopa has a broad spectrum antibacterial activity against other bacteria like Bacillus subtilis, Bacillus cereus, Salmonella typhi and Proteus vulgaris (R).
Bacopa plant extract is taken to treat gonorrhoea (R).
17) Bacopa May Help Prevent Cancer
Oral administration of alcoholic extract of Bacopa slowed the development of solid tumors (R).
Bacopa can protect the human brain cancer (neuroblastoma) cells against H2O2 and acrolein (R).
Bacopa (Stigmasterol) had a protective effect against Ehrlich Ascites Carcinoma in mice (R).
Alcoholic extract of Bacopa has anti-tumor activity against Daltons Lymphoma Ascites (DLA) (R).
Bacopa extract promotes the antioxidant status, reduces the rate of lipid peroxidation and the markers of tumor progression in the fibrosarcoma bearing rats (R).
Bacopa inhibited the proliferation of cells in human carcinoma of larynx (R).
Bacopa may be effective against DLA due to its radiomimetic, nucleotoxic and cytotoxic effect. It also inhibits cell division (R).
Studies also suggest Bacopa’s ability to prevent cancer is by preventing DNA replication of cancer cell lines (R).
Bacopa (cucurbitacins) has anti-tumerogenic activity by inducing cell cycle arrest at the G2/M phase and formation of multiplied cells (R).
18) Bacopa Promotes Longevity
The imbalance between oxidants and antioxidants during aging can be minimized by Bacopa (R).
Bacopa promoted longevity in worms (R).
19) Bacopa Helps Protect the Gut
Bacopa extract may protect the gut due to its predominant effect on mucosal defensive factors (R).
20) Bacopa has an Antifatigue effect
21) Bacopa is a Mild Sedative
Bacopa has a mild sedative property (R).
Bacopa plant has been studied for its sedative effect in dogs and frogs (R).
22) Bacopa Protects the Liver
Alcoholic extract of Bacopa also exerted a liver protective effect against morphine (R), Nitrobenzene (R), N-Nitrosodiethylamine (R) and “ferrous sulphate cumen hydroperoxide” (R) induced liver injury in rats.
23) Bacopa May Help Muscles
Bacopa (Ecdysterone) has an muscle growth promoting effect on mice, rats, and pigs (R).
24) Bacopa Promotes Hair Growth
Bacopa (leaves) is a component of a Herbal oil which showed excellent hair growth activity (R).
Bacopa (as a component of a herbal formulation) also significantly decreased hair loss in animals (R).
Alcoholic extracts of Bacopa, Emblica officinalis and Cyperus rotundus are useful in treating “Indralupta” (hair loss) in rats (R).
Bacopa promotes hair growth by an enlargement of follicular size and prolongation of the anagen phase (R).
25) Bacopa Relieves Pain and Fever
26-28) Bacopa Helps With Histamine Intolerance, Respiratory Problems and Allergies
Bacopa produced significant inhibition of carbachol-induced lung constriction in rats (R).
Bacopa possess broncho-vasodilatory activity, which is attributed mainly to inhibition of calcium ions (R).
Bronchodilatory property shown by Bacopa extract is reflected by a reduction in exhaling pressure (R).
29) Bacopa Protects Against Cigarette Smoke Damage
Bacopa (Bacoside A) has a protective effect against chronic smoking induced toxicity and can protect the brain from the toxic effects of cigarette smoking in rats (R).
Bacopa extract upgrades various impairments associated with neuronal and physiological changes in rats exposed to smoke from fireworks (R).
30) Bacopa Protects the Kidney and is a Diuretic
Bacopa is used as a diuretic (increases urine flow) (R).
31) Bacopa is Good For Skin Health
Bacopa (Bacoside A) was found to enhance wound healing of the skin in rats (R).
Bacopa is also used to treat ringworm (skin infection caused by a fungus) (R).
The wound healing activity of Bacopa (Bacoside A) was more effective in various wound models compared to the standard skin ointment Nitrofurazone (in rats) (R).
32) Bacopa may Reduce Morphine Dependence
33) Bacopa Increases Thyroid Hormones
The fresh whole plant of Bacopa is crushed and juice is taken along with cows milk for treating irregular menstrual cycles (R).
36) Bacopa is Effective for Snake Bite
Fresh root decotion of Bacopa has traditionally been used as an antidote for snake-bites and scorpion stings (R).
Bacopa powder (except the root portion) about 1 teaspoonful is given (with warm goat milk or black tea) as an antidote for snake bite (R) about 30 ml infusion is administered orally as antidote for Cobra bite (R1, R2).
37) Bacopa Prevents Convulsions and Epilepsy
Bacopa is a component of “Mentat” syrup which is used to treat children with febrile convulsions (R).
Bacopa had a potential protective effect on cognitive deficit associated with PHT (Phenytoin) therapy in mice (R).
Bacopa in combination with Gingko biloba extract has shown improved anti-cholinesterase and anti dementia activities in scopolamine induced amnestic mice (R).
Extract of Bacopa and rosemary is more neuroprotective than each of the extracts individually (R).
Bacopa Side Effects, Cautions, and Toxicity
Bacopa (Brahmi) treatment inhibited fertility and caused a suppression of sperm creation that was reversible – without producing toxic effects in male mice (R).
Bacopa was found to be safe and well tolerated by normal healthy male human volunteers in single dose (20-300 mg) and multiple doses (100 and 200 mg) (R).
No-observed adverse effect level of 500 mg/kg body weight was established in rats (R).
Active Chemical Constituents
Steroidal saponins and Bacosides A and B are the active chemical constituents responsible for improving both learning and memory (R).
- Increases enzyme tryptophan hydroxylase-2 (TPH2) (R).
- Increases Serotonin Transporter (SERT) (R).
- Increases Superoxide Dismutase (SOD) (R).
- Increases Catalase and Glutathione peroxidase (R).
- Increases Superoxide Dismutase (SOD) (R).
- Increases Catalase (CAT) (R).
- Increases selfdecode.com/gene/gpx1/?utm_source=seo&utm_medium=selfhacked&utm_campaign=id00002″>Glutathione peroxidase (GPx) (R).
- Increases Glutathione (GSH) (R).
Buying & Dosage
Daily doses of Bacopa are 5-10 grams of non-standardized powder, 8-16 ml of infusion and 30 ml daily of syrup (R). Dosages of a 1:2 fluid extract are 5-12 ml per day for adults and 2.5-6 ml per day for children ages 6-12 (R).
My preferred Bacopa Supplement: