We Made a New Release For SelfDecode!

We made a new release of SelfDecode!

SelfDecode is the best and most powerful genetics app out there.  It’s the only nutrigenomics company that is innovating.

As it stands, SelfDecode is the most powerful app that analyzes your genetics and gives back potential ways to fix it.

Recommendation Page

The recommendation engine is only one of the many features that we have.

Features

Selfdecode has over 100 features, and I will go through them over the coming days as I find time.

Natural Recommendations

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How it works:

  • We go through our database of about 1 million substances and we look through your genes and see which substances may help your potentially negative genes.
  • Natural recommendations are those that are categorized as natural and consumable.

Future improvements:

  • We are working on the categories better.  There are some substances that aren’t categorized correctly.
  • We are also improving the algorithm in picking the substances.

Interactions Between Potentially Bad Genes and Substances

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How it works:

  • Whenever we have a recommendation, we show you the interactions that the substance has with your potentially problematic genes.
  • The arrows tell you how the substance interacts with the potentially bad genes.  So the substance can do things that increases or decreases the gene. If the arrow is going up and down, it means it does both.
  • Hover over the gene and it gives you a short description of what the gene does.
  • Click on the gene and it will bring you to the gene page.
  • If an arrow is shaded blue, it means that most of the time, it’s beneficial when the gene changes the direction in that manner.
  • When the arrow is shaded dark red, it means that it’s usually not beneficial when the gene is changed in that direction.
  • If the arrow is unshaded, it means that we haven’t given the gene a direction in terms of what’s better most of the time

Future improvements:

  • We still have to give a direction to many genes.
  • We are working on giving directions to specific diseases.  So when you join the site, it will ask you which conditions you’re concerned about and it will show you the direction for those conditions, because most of the time, whether a gene should be increased or decreased depends on the condition that you are concerned about.

Beneficial substances for bookmarked SNPs

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How it works:

  • We go through our database of about 1 million substances and filter by the substances which are in the beneficial category.  Some substances are beneficial, but not natural – such as aspirin.
  • Over here, we only look at the genes you bookmarked.  You are capable of bookmarking any of the 20k genes in our database.  When you bookmark it, we try to look for a best fit for those selected genes.

Recommendations for specific genes, diseases on recommendation page

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How it works:

  • On the recommendations page, there is a section that asks people, which diseases they are concerned about. Once the disease is selected you can see beneficial substances which interact with your potentially problematic genes for that disease.  We look through your SNPs and flag the ones that have studies associated with your disease.  Then we show how a substance interacts with all of these genes.
  • You can also select genes in addition to diseases and you will see beneficial substances for selected genes.
  • Select Substance – Select from over 1 million substances to see how they interact with your personal genetics.

Autocomplete search feature for all of the pages in the database

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How it works

  • Type to search anything from our database: genes, SNPs, substances, diseases, measurements, traits, health effects…You will then be redirected to a page with a bunch of information.
  • You can also use search feature at the top of the page

SNP Analyzers

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The SNP Analyzer is an experimental feature that aims to aggregate SNPs regarding a certain topic. The information should not be viewed as accurate at this stage. Rather, a person should look at individual SNPs and make their own assessments. The SNP Analyzer contains nine packages: Disease Risk, Drug Response, Methylation, Aging, Response To Toxins, Diet, Lifestyle, Addiction Potential, Nutrition. You can choose which package you want to install or you can install them all.

How it works

  • The SNP Analyzer gives letter scores from “A+” to “F”. An “A+” would indicate that you function well with said trait or issue. A “C” indicates that you are average in the trait or issue. An “F” indicates that you should pay attention to the SNPs that might be problematic.Example 1:Depression Status: A +This means that you have a good amount of SNPs that cause you to be resilient to depression.Example 2:Early To Bed, Early To Rise: A+This means that you might be an early riser.  An “F” would indicate that you’re a night owl.Response To Stress: FThis means that you may not tolerate stress well.

Gene Packs page

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How it works

  • You can choose the genes that you most curious about and when you click on the “View” button  you can see them and download them in a form of variance report.
  • It contains 54 different categories: Joe’s Favorite Genes, Longevity, Cytokine Profile, Oxidative Stress Profile…
  • You can  see Beneficial Substance Recommendations For Problematic Genes in this Gene Pack and Targeted Beneficial Substance Recommendations For Problematic Genes in this Gene Pack
  • We have a section “create a gene pack”. You can press the button to create your own Gene Packs. After that, you will go to a page where you can type in the name that you want to call the gene pack, and a field which allows you to add genes to or delete genes from the pack.

Genes To Look Out For

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How it works

  • These are genes which have a large number of SNPs which are known to alter the function of the gene significantly. In other words, this tool gives you an idea of which of your genes you are most likely to function abnormally.
  • The results are based on a simple experimental algorithm so predictions should not be viewed as being accurate, but more as a guide to bring your attention to certain genes.
  • “Genes To Look Out For” have a bookmark option. If you bookmark them they will appear on “Bookmarked SNPs” page where you can see/download them in the variance report.

Summary and Function box on gene page

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How it works

  • We added a function box for most of the genes in our database, where you can read more about what certain gene does.

Top Gene-Substance Interaction

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How it works

  • Gives you graphical representation of interaction between the substance and the gene. You can see how the substance interacts with the gene and the number of interactions.
  • The arrows tell you how the substance interacts with the gene.  So the substance can do things that increases or decreases the gene. If the arrow is going up and down, it means it does both.

Gene Interacts with Diseases

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How it works

  • In the table you can see how the certain gene interacts with diseases, inference score and information about references/inference chemicals.
  • The inference score reflects the degree of similarity between CTD chemical–gene–disease networks and a similar scale-free random network. The higher the score, the more likely the inference network has atypical connectivity.

All Ways to Increase Gene

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How it works

  • It shows all the substances that increase the gene. You can also choose the category of substance.If the arrow is going up and down, it means that substance does both (increase and decrease).

All Ways to Decrease Gene

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How it works

  • It shows all the substances that decrease the gene. You can also choose the category of substance.If the arrow is going up and down, it means that substance does both (increase and decrease).

Conditions with Increased Gene Activity

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How it works

  • Here it will show all specified conditions that increase gene activity. You can choose the category of condition.
  • You can also click on “Experiment name” section and see the results.
  • Fold change is a measure describing how much a quantity changes going from an initial to a final value. For example, an initial value of 30 and a final value of 60 corresponds to a fold change of 1 (or equivalently, a change to 2 times), or in common terms, a one-fold increase. Fold change is calculated simply as the ratio of the difference between final value and the initial value over the original value. Thus, if the initial value is A and final value is B, the fold change is (B – A)/A or equivalently B/A – 1. As another example, a change from 80 to 20 would be a fold change of -0.75, while a change from 20 to 80 would be a fold change of 3 (a change of 3 to 4 times the original).

Conditions with Decreased Gene Activity

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How it works

  • Here it will show all specified conditions that decreased gene activity. You can choose the category of condition.
  • You can also click on “Experiment name” section and see the results.

Related SNPs

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How it works

  • Here you can see the list of all SNPs that are related to certain gene. Color red means that you have two minor alleles, green two major alleles and orange one minor and one major alleles.

Technical section on Gene page

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Shows technical data about certain gene.

Bookmark feature on SNP and Gene page

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How it works

  • We added bookmark feature on SNP and Gene page. If user bookmarks gene, all of the SNPs from that gene will show up on bookmarked page.
  • You can also see the beneficial substances for Bookmarked SNPs.

My Bad SNPs

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How it works

  • On “My Bad SNPs” page we added an area that allows people to type in their disease and it comes up with a variance report of the SNPs related to that disease that the person has risk alleles for.

My Important SNPs

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How it works

  • It gives you result in a form of variance report for all the SNPs which has value 5.
  • Importance is a value we assign to each SNP based on it’s veracity and impact. If there are many credible studies and they show substantial impact on health, this number will rise.

My Bad Rare SNPs

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How it works

  • It gives you result in a form of variance report for all bad SNPs. By default, 2 minor or less common alleles will display a red color.

Variance Report

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Filter through our database of 30,000 SNPs and see your variation from the normal population. Sort by SNP importance, minor allele frequency and reputation.

How it works

  • The variable report has filter dropdowns which allow you to filter by different criteria.
  • To see only bad SNPs, go to the dropdown box that say “All Reputations” and select the “Bad”. If you are only interested in the relatively important SNPs, click the “All Importance” dropdown and select the 3 or higher. The higher the number the more important the SNP. The MAF (minor allele frequency) filter allows you filter SNPs based on how rare the minor allele is, the lower the MAF, the rarer the SNP.
  • Hitting the Get SNPs button with no filters applied will retrieve all the SNPs in the database.
  • For each section in the variance report there is a tooltip with an explanation.
  • Search for term in the variance report (for example you can search a certain gene)
  • We added a red flag for risk alleles in the variance report
  • You can click on “i” for more information, the spanner for fixes or you can bookmark the SNP to save it for later.

Chemical page

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  • Definition/description box gives you information about certain chemical
  • Substance and problematic gene interaction shows how the chemical interact with certain gene. There is also a tooltip next to the gene that takes information from gene summary
  • Top gene interaction – gives you graphical representation of interaction between the substance and the gene. You can see how the substance interacts with the gene and the number of interactions.
  • General information – about metabolism, uses/sources, health effects…
  • Mechanism of action contains table with target name, mechanism of action and references

Disease page

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  • There is a summary box of certain disease
  • List of top genes associated with disease
  • My SNPs – table with genes, SNPs, genotype and risk alleles related to disease, there is also a table My SNPs Within Subcategories of This Disease.
  • Recommendation for genes related to disease.
  • Tables for “Disease interacts with genes” and “Disease interacts with chemicals” with inference score.
  • Processes Associated With Disease – read more about Molecular function and Biological processes associated with disease.

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