54 Natural Supplements, Agonists and Drugs to Increase Dopamine (and 12 things to AVOID)

Dopamine is the compound that fuels our drive and motivation. It increases attention, improves cognitive function, and stimulates our creativity. It makes us more social and extroverted and helps us form romantic and parental bonds. However, dopamine, when too high, can also have its drawbacks. Read on to discover 54 ways to increase dopamine and 12 factors that decrease it.

A Summary of What Dopamine Does

Dopamine is a neurotransmitter, which is a chemical released by neurons (nerve cells) to send signals to other nerve cells (R).

Many areas of the brain produce dopamine. It is produced in the ventral tegmental area (VTA in the image above) of the midbrain, the substantia nigra pars compacta, and the arcuate nucleus of the hypothalamus (R).

The most important dopamine pathway in the brain controls reward-motivated behavior (R).

Most types of rewards, such as new experiences or accomplishment, can increase dopamine levels in the brain. In addition, most addictive drugs and behavioral addictions can increase dopamine (R).

In addition, dopamine has many other important roles in humans, including movement, memory, attention, learning, sleep, and mood (R).

Dysfunctions of the dopamine system contribute to Parkinson’s disease, schizophrenia, restless legs syndrome, and attention-deficit hyperactivity disorder (ADHD) (R).

How to Increase Dopamine

Read more about the benefits and drawbacks of dopamine here.

The Dopamine Diet: An Ideal Diet to Increase Dopamine

The following diet will be optimal for increasing dopamine:

Our bodies produce dopamine from the amino-acid tyrosine. In turn, tyrosine can be produced from phenylalanine (R).

Bananas especially contain high dopamine and L-dopa levels (R, R).

Saturated fats can suppress dopamine. Equivalent intake of monounsaturated fats (from olive oil) protects against dopamine decreasing (R).

Green tea increases dopamine in rats (R, R), including its constituents Theanine and Caffeine.

Caffeine’s performance-enhancing effects are accomplished via dopamine. Caffeine maintains a higher dopamine concentration especially in those brain areas linked with attention (R).

You want to consume cholesterol rich foods because cholesterol is a precursor to Pregnenolone, which increases dopamine in animals (R, R).

Magnesium has antidepressant effects that can partially be tied to increasing dopamine activity in the brain (R).

Curcumin, found in the spice turmeric, increases dopamine concentration in the brain (R, R, R), by inhibiting MAO-mediated dopamine break down (R).

Resistant starch is a type of soluble fiber that increases butyrate.  Butyrate may increase dopamine levels (R, R).

Folate is needed for the production of dopamine (and serotonin). When your body is low in folate, it cannot produce dopamine and other monoamines efficiently, which may result in depression (R, R).

Nutritional or brewer’s yeast is rich in uridine.  Uridine-5′-monophosphate increases dopamine levels in rat brain (R).

Seafood, which contains DHA, can increase dopamine levels in the brain (R, R, R).

Oregano increases dopamine levels by decreasing dopamine break down and reuptake (R).

Both tyrosine and phenylalanine are found in protein-rich foods (R):

  • Chicken and Turkey
  • Fish
  • Almonds
  • Avocados
  • Bananas
  • Pumpkin and Sesame seeds
  • Dairy: Milk, Cheese, Yogurt, Cottage cheese
  • Legumes: Soy, Lima beans, Peanuts

Lifestyle to Increase Dopamine

1) Sun/Being outside/Bright Light

bigstock-Autumn-Girl-enjoying-nature-on-71045254-min

Bright light can improve our mood. This may partially be due to dopamine.

A study shows that light may increase dopamine, and thereby improve mood in women with mild seasonal mood disorder (R).

Light also stimulates the release of dopamine in the retina, and this is beneficial for maintaining good vision (R).

2) Exercise

bigstock-runners-running-on-beach-jogg-90536186-min

Exercise increases dopamine (R, R).

A study in women showed that exercise decreases COMT activity, thereby increasing dopamine in women (in prefrontal cortex) (R). COMT is the enzyme that breaks down dopamine.

3) Meditation

bigstock-Closeup-of-woman-s-hands-medit-125187953-min

Meditation increases dopamine release (R, R).

However, the effects seem to be transient unless meditation is done regularly.

A study shows that long-term meditation practice is needed to induce stable changes in baseline dopamine (striatum) (R).

4) Yoga

3 months of practicing yoga increased dopamine levels in men (in blood/circulating levels) (R).

The study revealed that yogic practices might help in the prevention of age-related degeneration….in healthy males.

5) Touch

bigstock-Happy-loving-family-Mother-an-131088716-min

Pleasurable physical contact can increase dopamine.

In rats, it was shown that stroking increases dopamine release (nucleus accumbens) (R).

Tickling, as a form of play behavior in adolescent rats, also increases dopamine release (nucleus accumbens) (R).

In early life, stimulation from touching improves spatial working memory in rats, possibly by improving dopamine function (R).

6) Massage therapy

bigstock-Total-Relaxation--86237039-min

Massage therapy increases dopamine, with a 31% increase of urinary dopamine in people (R).

Massage increased dopamine levels in pregnant women with depression (R) and in adolescents with bulimia (R).

7) Music

bigstock-technology-lifestyle-and-peop-92265983-min

Parts of the brain release dopamine when listening to pleasurable music (striatum, nucleus accumbens) (R, R, R, R).

Not just listening, but creating and performing music also produce dopamine (R).

Food to Increase Dopamine

8) Tyrosine- and phenylalanine-rich food

bigstock--170551064-min

Our bodies produce dopamine from the amino-acid tyrosine. In turn, tyrosine can be produced from phenylalanine (R). Both tyrosine and phenylalanine are found in protein-rich foods (R): chicken, turkey, fish, peanuts, almonds, avocados, bananas, milk, cheese, yogurt, cottage cheese, lima beans, pumpkin seeds, sesame seeds and soy.

Bananas especially contain high dopamine and L-dopa levels (R, R).

9) Unsaturated fat

Saturated fats can suppress dopamine. Equivalent intake of monounsaturated fats protects against dopamine decreasing (R).

Supplements That Increase Dopamine

10) Tyrosine

dopamine_production
http://www.nature.com/nrn/journal/v7/n4/fig_tab/nrn1883_F1.html

Tyrosine supplementation increases dopamine levels in the brain (R, R, R).

A study shows that tyrosine supplementation effectively enhances cognitive performance, particularly in short-term stressful and/or cognitively demanding situations when dopamine is temporarily depleted (R, R).

11) Green Tea

bigstock-green-tea-86709173-min

Green tea increases dopamine in rats (in blood, stress model) (R, R).

Theanine, one of the major amino acid components in green tea, increases dopamine in animals (R, R, R).

12) Caffeine

bigstock--157064345-min

Caffeine increases dopamine release (striatum, nucleus accumbens) (R, R).

Caffeine’s performance-enhancing effects are accomplished via dopamine. Caffeine maintains a higher dopamine concentration especially in those brain areas linked with attention (R).

13) Pregnenolone

Pregnenolone sulfate increases dopamine in animals (striatum, nucleus accumbens) (R, R).

14) Magnesium

Magnesium has antidepressant effects that can partially be tied to increasing dopamine activity in the brain (R).

15) St. John’s wort

bigstock-Saint-john-s-wort-Flowers-95115728-min

A number of studies have shown that St. John’s Wort, an herbal anti-depressant, increases dopamine content in the brain (nucleus accumbens, striatum) (R, R, R, R, R).

16) Gingko

bigstock-Ginkgo-Tea-With-Fresh-Leaves-113256551-min

Gingko biloba increases dopamine and dopamine neuron activity (PVN, VTA, Nucleus Accumbens) (R, R, R). This increase in dopamine may partially explain the improvement of cognitive function observed with Gingko supplementation.

17) Curcumin

bigstock-turmeric-powder-in-spoon-and-r-102350429-min

Curcumin increases dopamine concentration in the brain (R, R, R), by inhibiting MAO-mediated dopamine break down (R).

18) Butyrate

Butyrate may increase dopamine levels in animals in response to toxic injuries (striatum) (R, R).  You can get butyrate in the diet by consuming soluble fibers found in fruits and vegetables or ghee.

19) Folate

Folate is found in leafy greens/vegetables and is needed for the production/synthesis of dopamine (and serotonin). When your body is low in folate, it cannot produce dopamine and other neurotransmitters (monoamines) efficiently, which may result in depression (R, R).

20) Huperzine A

Huperzine A is a substance that is known to increase acetylcholine, but it also increases dopamine levels 129% above baseline in rats (cortex) (R).

This substance may help with treating drug addiction (R).

21) SAM-e

S-Adenosyl-l-methionine (SAM-e) is an over-the-counter dietary supplement commonly used to treat depression. SAMe helps in the production of dopamine and other monoamines, causing elevations in dopamine levels (R).

22) Shilajit

Shilajit is a naturally occurring biomass found in Himalayas. In traditional Indian medical practice to be useful in the treatment of nervous disorders, epilepsy and as an antistress agent.

Shilajit increases the levels of neuronal dopamine in the brain, which has an anxiety suppressing action (R).

23) Uridine

Uridine-5′-monophosphate increases dopamine levels in rat brain when the neurons are activated (striatum) (R). Uridine is found very concentrated in nutritional and brewer’s yeast, meat and fish.

24) Fish Oil

Seafood/Fish Oil/DHA can increase dopamine levels in the brain in rats (striatum). Dopamine levels were also 40% greater in the frontal cortex of rats fed fish oil.  DHA treatment led to a 89% rise in tyrosine-hydroxylase terminals within the striatum in lesioned animals (R, R, R).

25) Ginseng

bigstock-Fresh-Ginseng-Root--74672641-min

Ginseng components can increase levels of dopamine in the brain and have beneficial effects on attention, cognitive processing, sensorimotor function and auditory reaction time in healthy subjects (R).

However, ginseng can also blunt dopamine release in response to other stimulants such as nicotine and cocaine (R, R).

26) Danshen

Red sage, also known as danshen (Salvia miltiorrhiza), may increase dopamine in cells (striatum) (R).

27) Resveratrol

Resveratrol can increase dopamine levels in the brain in animals (frontal cortex, striatum).  Resveratrol treatment in old rats increased dopamine by 53% (striatum) (R, R).

28) Oregano

bigstock--148419617-min

Oregano extract increases dopamine levels by decreasing dopamine break down and reuptake in animals (R).

29) Carvacrol

Carvacrol, present in the essential oil of many plants including oregano and thyme oils, acts as an antidepressant by activating the dopamine system in mice (R).

At low concentrations (what’s in oregano and supplements), carvacrol increases dopamine. However, in high concentrations, it may decrease dopamine levels (R).

30) Clary sage

bigstock--162480416-min

Clary sage (Salvia sclarea) oil increases dopamine activity in rats, which contribute to its anti-depressant effects (R).

31) Bacopa

Bacopa (Bacopa monnieri) extract can increase dopamine in rats (in cortex, hippocampus) and have a nootropic effect (R, R).

32) Mucuna pruriens

bigstock--143203232-min

Mucuna pruriens has a high concentration of L-Dopa (4–7%), which is a precursor of dopamine (R).

Mucuna pruriens, an ayurvedic plant, was shown to increase dopamine in mice (R, R).

33) Catuaba

bigstock-Catuaba-bark-herb-used-in-natu-116719484-min

The Brazilian medical plant catuaba (Trichilia catigua), increases dopamine release and may have dopamine-mediated antidepressant effects (R).

The herbal product containing this plant, catuama, has similar effects (R).

34) Rosemary

bigstock--161001197-min

Rosemary (Rosmarinus officinalis) increases brain dopamine levels (R).

35) Kava

Higher doses of kava (Piper methysticum) increase levels of dopamine in rats (nucleus accumbens). Individual compounds isolated from kava can both increase or decrease dopamine concentration (R, R).

However, in a couple of cases, blocked dopamine function has also been observed (R).

36) Lactobacillus plantarum

The probiotic Lactobacillus plantarum can increase dopamine in the brain in mice (striatum), and could potentially improve anxiety-like behaviors and psychiatric disorders (R, R).

35) Fresh Cut Grass/Essential Oils

Hexanal is a “green” odor compound found in plants that may increase dopamine in rats (striatum) (R, R). Increasing dopamine is a potential mechanism in which green odors, such as fresh cut grass and plant essential oils, may improve mood and attention.

36-41) Flowering Quince, Psoralea coryfolia, Mycoleptodonoides aitchisonii, Blue trumpet vinePrickly nightshade, Gardenia jasminoides

Flowering quince, the fruit of Chaenomeles speciosa used in Chinese traditional medicine, increases dopamine levels by inhibiting the dopamine transporter (DAT) (R).

Psoralea corylifolia fruit/seed extract and its components increase dopamine (R, R). This plant is used both in Ayurveda and Chinese traditional medicine.

The edible mushroom Mycoleptodonoides aitchisonii increases dopamine (R).

Blue trumpet vine (Thunbergia laurifolia) is a Thai herbal medicine used to treat drug addiction. It works by increasing dopamine (R, R).

Prickly nightshade (Solanum torvum) increases dopamine and shows antidepressant activity (R).

Gardenia jasminoides can increase dopamine by inhibiting MAO-A and B (R).

Hormones that Increase Dopamine:

42) Estrogen

Estrogen may increase dopamine. Women act more impulsively in the early as opposed to the late phase of menstrual cycle (R).

In rats, estrogen-induced improvements in recognition memory were shown to be due, in part, to increased dopamine (R).

However, dopamine’s relationship to cognitive performance is not linear—dopamine function follows an ‘inverted U-shaped’ curve, where optimal dopamine results in maximal function and both insufficient or excessive levels lead to dysfunction (R). That is why too much estrogen is not beneficial.

43) Ghrelin

Ghrelin stimulates dopamine release in rats (amygdala, nucleus accumbens, VTA, prefrontal cortex) (R, R).

Dopamine Drugs/Agonists

44) Nicotine

Nicotine “hi-jacks” the reward circuitry in the brain by increasing dopamine release (striatum, VTA, amygdala, nucleus accumbens, prefrontal cortex) (R, RR).

45) L-dopa

dopamine_production2
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967375/

L-dopa is made from tyrosine, and then converted into dopamine. Basically, it is the precursor of dopamine (R).

46) Bromantane

Bromantane increases the amount of dopamine in the brain by increasing its synthesis from tyrosine (increases Tyrosine Hydroxylase, AAAD) (R, R).

Enhancement of dopamine is observed in the hypothalamus, striatum, ventral tegmental area, nucleus accumbens, and other regions (RRR).

By increasing dopamine, Bromantane increases alertness and wakefulness (R) and improves short-term memory, motivation, planning abilities, and attention (R).

47) Tianeptine

Tianeptine increases the release of dopamine in rats (nucleus accumbens > striatum) (R).

48) Phenibut

Phenibut is a nootropic drug that stimulates dopamine receptors (R).

49) Alcohol

bigstock--157008986-min

Dopamine release may contribute to the rewarding effects of alcohol and may thereby play a role in promoting alcohol consumption (nucleus accumbens) (R).

50) Methylphenidate/Amphetamines

Amphetamine exerts rewarding and reinforcing effects by elevating dopamine and prolonging dopamine receptor signaling (R).

Methylphenidate works in the treatment of ADHD by increasing levels of dopamine in children’s brains.

Previous research has shown that some people with attention deficit hyperactivity disorder may have too many dopamine transporters, which results in low levels of dopamine in the brain.

The drug seems to raise levels of dopamine by blocking the activity of dopamine transporters, which remove dopamine once it has been released (R).

51) Modafinil

Modafinil seems to inhibit the reuptake of dopamine by dopamine transporter, thereby increasing dopamine concentration in humans (R, R).

52) Deprenyl

Deprenyl (Selegiline) increases dopamine by blocking MAO-B, an enzyme that breaks down dopamine (R).

53) MDMA

MDMA/Ecstasy increases dopamine (R).

54) Cocaine

Cocaine inhibits the dopamine transporter responsible for dopamine recycling, thereby increasing dopamine levels (R).

Decreasing Dopamine

Drugs and Supplements that Decrease Dopamine

1) Anti-psychotics

In cases of schizophrenia, you can use anti-psychotic drugs to lower dopamine signaling by blocking dopamine receptors (R).

2) Melatonin

Melatonin suppresses dopamine activity (R).

3) Lithium

Lithium impairs dopamine release (R, R).

4) Manganese

bigstock-Pills-with-manganese-MN-elemen-174862726-min

Long-term manganese decreases dopamine release in the brain (R, R).

A study showed that manganese exposure, even within the safety limit, decreased dopamine production in primates (R).

5) Liriodenine

Liriodenine inhibits dopamine production and decreases dopamine levels (R).

6) Salvinorin A

Derived from the plant Salvia divinorum, Salvinorin A decreases dopamine (R).

7) 5-HTP

Serotonin shares the same conversion and breakdown enzymes with dopamine.

Long-term supplementation with 5-HTP, the immediate precursor of serotonin, can cause dopamine depletion, which can worsen neurological and psychiatric diseases (R).

Conditions that decrease dopamine

8) Inflammation

Inflammation decreases dopamine (R). That’s why we feel less motivated and more sluggish when we are sick (R).

9) Maternal Depravation

Maternal deprivation of rat pups leads lower dopamine levels. However, these pups reared in isolation have higher dopamine increase in response to stress (R).

10) Diet High in Saturated fats

bigstock-Sources-Of-Saturated-Fats-113729336-min

Saturated fats can suppress dopamine (R, R).

11) Chronic Sugar Intake

bigstock--172017440-min

Sugar acutely increases dopamine, which, over time, leads to a reduced number of dopamine (D2) receptors and possibly a reduction in dopamine itself, leading to desensitization. These effects would not be due to the acute effects of sugar, but rather would occur over weeks to months with chronically elevated and intermittent sugar ingestion (R).

12) Iron Deficiency

Iron is a cofactor for tyrosine hydroxylase, a key enzyme in dopamine production (R). Iron-deficient rats have reduced brain dopamine levels (R).

Low brain iron stores may contribute to ADHD symptoms because low iron levels in the brain can alter the activity of dopamine (R).

Weaning rats fed an iron deficient diet showed decreased physical activity and increased anxiety-like behavior with a reduction of brain dopamine receptors (R).

However, some studies indicate iron deficiency has the exact opposite effect (R).

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967083/figure/Fig3/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967083/figure/Fig3/

Comments

  1. Rob

    You say saturated fat decreases DA. However, at the same time, also say that eating cholesterol rich foods is good for pregnenolone which increases DA.

    Additionally, isn’t saturated fat also *good* for brain health in many other ways?

    I have low cholesterol levels naturally (around 100-110 total) so consuming saturated fats are pretty important for me at least but then again I am kind of unique there.

    Also what about Testosterone? Doesn’t it increase DA somehow?

Leave a Reply