This post is a summary of a few other posts, in a more readable format.


132 Different Mechanisms for Weight Modulation


See the following posts, which have the 132 different mechanisms that’re listed here:

Now, most of these have more complex effects, but I was hoping to simplify it and mention on the whole what it does.

References are in the full posts and also contains the full names for these.

Some mechanisms are better established than others.  Seeing the full post explores more of the specifics.

Pro Weight Gain

Pro Weight Loss

Mixed Effects

  • AMPK activation in the hypothalamus cause weight gain, but in the muscle causes fat burning (R).
  • DHEA might have gender specific effects – men lose and women gain weight (R).
  • Serotonin has tissue-specific effects – it causes weight gain in the body but weight loss in the hypothalamus (R).
  • mTOR activation has tissue-specific effects. Activation in the hypothalamus reduces food intake, while in fat cells, it increases fat mass.
  • Acetylcholine causes mixed effects. Acetylcholine helps weight loss through nicotinic receptors but can cause weight gain through muscarinic receptors.
  • LXR has mixed effects on weight (R).

Genetic variation in PFKP, KCNJ11, PTER and SEC16B were associated with obesity (R).

Health Tools I Wish I Had When I Was Sick

At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on pubmed to figure out how the body worked and how to fix it.

That’s why I decided to create tools that will help others cut down the guesswork:

  • Lab Test Analyzer – a software tool that will analyze your labs and tell you what the optimal values are for each marker — as well as provide you with actionable tips and personalized health and lifestyle recommendations to help you get there.
  • SelfDecode – a software tool that will help you analyze your genetic data from companies such as 23andme and ancestry. You will learn how your health is being impacted by your genes, and how to use this knowledge to your advantage.
  • SelfHacked Secrets – an ebook where we examine and explain the biggest overlooked environmental factors that cause disease. This ebook is a great place to start your journey if you want to learn the essential steps to optimizing your health.
  • SelfHacked Elimination Diet course – a video course that will help you figure out which diet works best for you
  • Selfhacked Inflammation course – a video course on inflammation and how to bring it down
  • Biohacking insomnia – an ebook on how to get great sleep
  • Lectin Avoidance Cookbook – an e-cookbook for people with food sensitivities
  • BrainGauge – a device that detects subtle brain changes and allows you to test what’s working for you
  • SelfHacked VIP – an area where you can ask me (Joe) questions about health topics


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