Too little NQO1 is almost a certainly contributor to chemical sensitivity, lower energy and sensitivity to supplements.
- Sensitive to supplements?
- Sensitive to toxins?
- Have a biotoxin issue?
- Experiencing oxidative stress?
If yes, then you need to read this post…
If you want to interpret your genes, you can use SelfDecode.
About NQO1 (NAD(P)H dehydrogenase (quinone 1))
NQO1 helps with stresses such as from polyaromatic toxins and carcinogens, or by helping break down superoxides and peroxides. NQO1 directly scavenges superoxide (R).
NQO1 is employed in the removal of a quinone from biological systems as a detoxification reaction: NAD(P)H + a quinone → NAD(P)+ + a hydroquinone (R).
Many of the hydroquinone products then get bound to glucuronides and sulfates and excreted (R).
NQO1 is concentrated in blood vessel tissue of mice, rats, and humans to deactivate toxins when they enter the blood stream (R).
NQO1 is important in activating vitamin K to allow it to function well, which allows for blood clotting, bone health and also anti-tumor properties (R).
NQO1 changes ubiquinone to ubiquinol (R).
NQO1 increases the enzyme (Ornithine decarboxylase) for polyamine synthesis (like spermidine) (R). Polyamines like spermidine are antiaging and healthful compounds.
Low levels of NQO1 has been associated with (R):
- Many tumors – individuals with decreased NQO1 expression/activity have reduced p53 stability. Several anti-tumor agents such as mitosenes, indolequinones, aziridinylbenzoquinones and β-lapachone have been designed be bioactivated by NQO1.
- Alzheimer’s disease
Since oxidative stress causes an inflammatory reaction, NQO1 ameliorates some animal models of autoimmune diseases (R).
Top Ways to Increase NQO1
I notice an energy boosting effect from Pau Darco.
Oleanolic acid is a good way to increase NQO1 (R). However, oleanolic acid supplements don’t contain enough of it or it’s not from a reliable company. I still take/have taken all of the ones I recommend.
Less NQO1 will result in less ubiquinol, so I recommend supplementing with that.
Health Tools I Wish I Had When I Was Sick
At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on pubmed to figure out how the body worked and how to fix it.
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- SelfHacked Elimination Diet course – a video course that will help you figure out which diet works best for you
- Selfhacked Inflammation course – a video course on inflammation and how to bring it down
- Biohacking insomnia – an ebook on how to get great sleep
- Lectin Avoidance Cookbook – an e-cookbook for people with food sensitivities
- BrainGauge – a device that detects subtle brain changes and allows you to test what’s working for you
- SelfHacked VIP – an area where you can ask me (Joe) questions about health topics