PGC-1a is critical to proper mitochondrial function. If you’ve got mitochondrial problems, this post is a must.
Do You Have Low PGC-1a?
If you answer yes to these, then that may indicate low PGC-1a:
- Do you get tired often?
- Do you have a low metabolism?
- Do you lack energy in the day?
- Do you have a disturbed circadian rhythm?
- Do you have chronic inflammation?
PGC-1a is one of the most important factors in controlling mitochondrial health. It’s also important for circadian rhythms, energy metabolism, fat metabolism, weight loss, blood pressure, cholesterol homeostasis and indirectly can help detoxing and drug metabolism.
Intro to PGC-1a
PGC-1a is one of the most important factors in controlling mitochondrial health. PGC-1α makes new mitochondria and improves its function.
PGC-1α increases energy metabolism and weight loss.
This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homeostasis, and the development of obesity.
PGC-1a protects against neurodegenerative diseases.
Mice lacking PGC-1 alpha show abnormal circadian rhythms, body temperature, and metabolic rate .
Increasing PGC-1a helps mitigate symptoms of genetic muscle disorders in animal models .
How to Increase PGC-1a
- PQQ 
- Hydroxytyrosol 
- Resveratrol 
- Nicotinamide Riboside 
- EGCG/Tea 
- Gotu Kola 
- Grape Seed Extract 
- R-Lipoic Acid 
- Epimedium  and Icariin 
- Carnitine 
- Rhodiola/Salidrosides 
- Aspirin 
- Quercetin 
- Forskolin/Cyclic AMP 
- Red yeast rice 
I’ve already discussed some common pathways to activate PGC-1a. This means that if you activate these, it will help activate PGC-1a.
What Decreases PGC-1a and Its Activity
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