Evidence Based
4.1 /5
23

Natural Ways To Modify Costimulatory Molecules

Written by Joe Cohen, BS | Last updated:

SelfHacked has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. We believe that the most accurate information is found directly in the scientific source.

We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic.

Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists.

Our science team goes through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again.

Our goal is to not have a single piece of inaccurate information on this website. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at [email protected]

Note that each number in parentheses [1, 2, 3, etc.] is a clickable link to peer-reviewed scientific studies. A plus sign next to the number “[1+, 2+, etc...]” means that the information is found within the full scientific study rather than the abstract.

Some people may need to decrease both Th1 and Th2. Read on for natural hacks to decrease inflammation, from supplements to lifestyle.

“It is not a daily increase, but a daily decrease. Hack away at the inessentials.”
– Bruce Lee

Top 7 Recommendations

I realize many people just want the bottom line. Here it is:

All of these can be combined, but start by taking one at a time for a few days before you start stacking.

Supplements/Methods To Decrease Both Th1 and Th2

Supplements that increase IL-10 will decrease both kind of T cells [12].

Decreasing Inflammation By Inhibiting CD26, CD40, CD80, CD86, MHC

CD26, CD40, CD80, CD86, and MHC are molecules on T helper cells, dendritic and other immune cells. These proteins are stimulatory and activate T helper cells [37]. Decreasing them should help inflammatory conditions regardless of Th1/Th2 dominance.

The more these costimulatory signals cause the division of T cells, the more likely they are then to become ‘dormant’ [38].

By inhibiting these molecules, you also inhibit the maturation of dendritic cells [39]. When these cells mature they become harmful.

Interleukin-10 has (1) immunosuppressive effect and (2) immunostimulatory effect. It down-regulates the expression of Th1 cytokines, MHC class II antigens and co-stimulatory molecules on macrophages.

There’s lots of contradictory information on zinc, but overall I am for supplementation unless you’re eating a lot of organ meat. Zinc has been shown to be beneficial in animals with higher than RDA levels and is especially important for the elderly [72]. Zinc is also a good cancer preventative [73]. Too much isn’t good, though.

Supplements That May Balance Th1/Th2 Immune System

  • Grape seed extract [74]****Contradictory [75] – probably balancing
  • Pine bark [76] – likely has the same effect as GSE
  • Eleuthero/Siberian ginseng. A study shows it decreases cytokines that create Th1 and Th2 cells in healthy people [77], but a cellular study shows that it increases cytokines that are released by Th2 cells [78]. It’s probably immune balancing.
  • Baicalin/Chinese Skullcap [36]
  • Rooibos [79]. This has mixed effects and probably balances Th1/Th2
  • Tribulus [80+81]

Be Wary: Supplements/Methods That Increase Both Th1 and Th2

  • Thyroid hormones [14]. I can confirm this through experimentation. When my thyroid hormone levels are higher, the inflammation I get from the foods I’m intolerant to goes up 2-3 fold.
  • Elevated IGF-1 [82]. IGF-1 is elevated by insulin secretion and amino acids like BCAA’s, leucine, methionine, lysine, and tryptophan [83]. Contradictory
  • Dairy (Bovine serum albumin, β-Lactoglobulin) [84]
  • Ozone [85]
  • Asian Ginseng [86] – Mostly stimulating, but also regulating. Ginseng has many compounds in it and the effects are complex and depend on dosage and other factors, but it seems to increase both systems in response to many types of immune challenges, even innocuous ones.
  • Tulsi [87]
  • Tocotrienols [88]
  • Bacopa [89]
  • Rhodiola [90]
  • Echinacea [89]* – contradictory, probably only increases Th2.
  • Tart Cherry [91]
  • Aloe [92] – (increases IL-1, IL-6, and TNF-α in cancer cells)
  • Almonds – specifically the skin [93]
  • Asparagus Racemous [92]
  • Licorice [92] – but eventually downregulates it because of glucocorticoids.
  • Goji Berries [94] (increases IL-12, TNF, IL-1b, Nf-kB, AP-1, CD40, CD80, CD86 and MHC II)
  • IFNy [95] (increases MHCII)
  • Lauric acid, (CD40, CD80, CD86) [96]

Want More Targeted Ways to Combat Inflammation?

If you’re interested in natural and more targeted ways of lowering your inflammation, we at SelfHacked recommend checking out this inflammation wellness report. It gives genetic-based diet, lifestyle and supplement tips that can help reduce inflammation levels. The recommendations are personalized based on your genes.

SelfDecode is a sister company of SelfHacked. The proceeds from your purchase of this product are reinvested into our research and development, in order to serve you better. Thank you for your support.

About the Author

Joe Cohen, BS

Joe Cohen won the genetic lottery of bad genes. As a kid, he suffered from inflammation, brain fog, fatigue, digestive problems, anxiety, depression, and other issues that were poorly understood in both conventional and alternative medicine.Frustrated by the lack of good information and tools, Joe decided to embark on a journey of self-experimentation and self-learning to improve his health--something that has since become known as “biohacking”. With thousands of experiments and pubmed articles under his belt, Joe founded SelfHacked, the resource that was missing when he needed it. SelfHacked now gets millions of monthly readers.Joe is a thriving entrepreneur, author and speaker. He is the CEO of SelfHacked, SelfDecode and LabTestAnalyzer.His mission is to help people gain access to the most up-to-date, unbiased, and science-based ways to optimize their health.
Joe has been studying health sciences for 17 years and has read over 30,000 PubMed articles. He's given consultations to over 1000 people who have sought his health advice. After completing the pre-med requirements at university, he founded SelfHacked because he wanted to make a big impact in improving global health. He's written hundreds of science posts, multiple books on improving health, and speaks at various health conferences. He's keen on building a brain-trust of top scientists who will improve the level of accuracy of health content on the web. He's also founded SelfDecode and LabTestAnalyzer, popular genetic and lab software tools to improve health.

Click here to subscribe

RATE THIS ARTICLE

1 Star2 Stars3 Stars4 Stars5 Stars
(7 votes, average: 4.14 out of 5)
Loading...

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.