Information is sparse on C4a, but I’ve tried to gather what there is. C4a is often elevated in chronic inflammation.
C4A is not what your doctor would usually test, even though it can tell you a lot about your health. However, you can request it from your doctor and plug your test results into Lab Test Analyzer. You will find all the information you need about your C4A values, such as if your levels are optimal. And if they are not, it will tell you how to get there, using evidence-based lifestyle, diet, and supplement tips.
Intro to C4A
C4A is part of a “complement” group. The term complement means it is able to kill bacteria and contributes to immune defenses. However, if there are too many compliments, it can cause tissue damage and trigger an allergic reaction.
C4A is an activation protein, which means it also activates the other complement proteins to increase in level [R].
They also mediate inflammation and the generation of free radicals [R].
C4a activates Neutrophils, which increases inflammation and free radicals [R].
You can request that your doctor test your C4A. Conventional doctors will look at high or low C4A levels and not mention anything. Sometimes, a lab result may be in the reference range, but not actually be in the optimal range. Reference ranges are not the same as optimal ranges. This is why C4A even in the ‘normal’ range can be unhealthy and indicate that certain processes in the body aren’t optimal. Lab Test Analyzer will let you know if your C4A levels are optimal and what you can do to get them there if they aren’t.
What Increases C4A?
There are three general pathways by which the body increases C4a: The Alternative Pathway, The Lectin Pathway, and The Classical Pathway.
These pathways are activated by infections, which include bacteria, fungi, viruses, and parasites. Immunoglobulins (IgG, IgM) and CRP can also increase C4a (they can be high in infections). The body often detects infections by the toxins that they give off, so toxins may also increase C4a.
Conditions With Elevated C4A
C4A appears to be an immune marker (has increased levels) in the following disorders:
- Lyme Disease [R, R]
- CFS [R]
- Psoriasis [R]
- Eczema [R]
- Antiphospholipid syndrome [R]
- Lupus [R] and higher C3a [R]….According to one study, lower C4a contributes to lupus [R].
- AIDS [R]
- Schizophrenia [R]
- Acute pancreatitis [R]
1) C4A and Mold Illness
It’s been observed that C4A levels can be increased in people with Lyme disease [R].
C4A levels may be decreased with mold avoidance (anecdotal) and antibiotic treatments [R].
2) C4A and Lyme Disease
Some researchers are looking at C3A and C4A levels to diagnose Lyme disease [R].
One must realize, however, that C3A and C4A and general markers, and will never be able to diagnose Lyme disease specifically (see images above).
3) C4A and CFS (Chronic Fatigue Syndrome)
One study found that C4a goes up after exercise in people with CFS [R].
A case study found that a CFS patient felt better after their C4a normalized [R].
4) C4A and Histamine Intolerance
Many people who believe they have histamine intolerance have high C4a because this activates mast cells.
Irregular C4A Levels?
If you have not yet tested your C4A levels, I recommend that you ask your doctor to do it. If you already have your blood test results and you’re not sure what to make of them, you need to check out Lab Test Analyzer. It does all the heavy lifting for you. No need to do thousands of hours of research on what to make of your various blood tests.
People don’t realize that their blood test results contain a gold mine of information that’s waiting to be unearthed. Unfortunately, not everyone has the time or the inclination to sift through dozens of research papers.
It’s super-simple, so that even if you don’t have any background in science, you will understand what your results mean and what you can do to get them in the optimal range.
Lab Test Analyzer gives you up-to-date scientific information about your lab results. In addition, you will get both lifestyle tips and natural solutions to help you optimize your health. You can also rely on our science-based Optimal Ranges to prevent potential health issues and maximize your overall well-being.
All of the content is backed by science and researched by a team of PhDs, professors, and scientists.
We’re all unique, so we deserve solutions that treat us that way.
Health Tools I Wish I Had When I Was Sick
At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on pubmed to figure out how the body worked and how to fix it.
That’s why I decided to create tools that will help others cut down the guesswork:
- Lab Test Analyzer – a software tool that will analyze your labs and tell you what the optimal values are for each marker — as well as provide you with actionable tips and personalized health and lifestyle recommendations to help you get there.
- SelfDecode – a software tool that will help you analyze your genetic data from companies such as 23andme and ancestry. You will learn how your health is being impacted by your genes, and how to use this knowledge to your advantage.
- SelfHacked Secrets – an ebook where we examine and explain the biggest overlooked environmental factors that cause disease. This ebook is a great place to start your journey if you want to learn the essential steps to optimizing your health.
- SelfHacked Elimination Diet course – a video course that will help you figure out which diet works best for you
- Selfhacked Inflammation course – a video course on inflammation and how to bring it down
- Biohacking insomnia – an ebook on how to get great sleep
- Lectin Avoidance Cookbook – an e-cookbook for people with food sensitivities
- BrainGauge – a device that detects subtle brain changes and allows you to test what’s working for you
- SelfHacked VIP – an area where you can ask me (Joe) questions about health topics