Evidence Based This post has 18 references
5 /5
0

Can Agaricus Blazei Fight Coronavirus (COVID-19)?

Written by Carlos Tello, PhD (Molecular Biology) | Last updated:
Puya Yazdi
Medically reviewed by
Puya Yazdi, MD | Written by Carlos Tello, PhD (Molecular Biology) | Last updated:

SelfHacked has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. We believe that the most accurate information is found directly in the scientific source.

We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic.

Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists.

All of our content is written by scientists and people with a strong science background.

Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again.

Our goal is to not have a single piece of inaccurate information on this website. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at [email protected]

Note that each number in parentheses [1, 2, 3, etc.] is a clickable link to peer-reviewed scientific studies. A plus sign next to the number “[1+, 2+, etc...]” means that the information is found within the full scientific study rather than the abstract.

This article is for informational purposes only. The current coronavirus outbreak is an ongoing event and certain details may change as new information comes to light. No effective or FDA-approved products are currently available for the treatment of the new coronavirus (also known as SARS-CoV-2 or 2019-nCoV), although research is still ongoing. 

Anti Infection Potential

In a small trial on 5 people with chronic hepatitis C, Agaricus blazei extract slightly reduced viral load and induced some immune-related proteins [1].

In cell-based studies, Agaricus blazei polysaccharides inhibited the viruses that cause:

  • Poliomyelitis [2]
  • Oral and genital herpes [3, 4]
  • Common flu [5]
  • Western equine encephalitis [6]

Unfortunately, no studies exist even in cells on how agaricus would affect coronaviruses. Even if there were studies in cells, we wouldn’t know if it would translate to humans at all.

Immune Stimulation

Agaricus does have general immune stimulatory properties, which may be good in general if you’re immunodeficient, but no clinical trials have been done with regard to infections, including COVID-19 infections.

The cell wall of Agaricus blazei and other fungi contains β-glucans that are recognized by immune cells and stimulate the immune response [7, 8].

In a clinical trial on 100 women with gynecological cancers, treatment with Agaricus blazei extract increased natural killer cell activity [9].

In cells, beta-glucan-rich Agaricus blazei extracts increased the production of cytokines (TNF-alpha, IL-1beta, IL-6, IL-8, and MCP-1) growth factors (G-CSF), and messenger molecules (nitric oxide and ROS) [10, 11, 12, 13, 14].

In mice, Agaricus blazei extract enhanced the effectiveness of the vaccines against foot-and-mouth disease [15] and hepatitis B [16].

In asthmatic mice, Agaricus blazei prevented allergic episodes by reducing Th2 dominance [17, 18].

About the Author

Carlos Tello

Carlos Tello

PhD (Molecular Biology)
Carlos received his PhD and MS from the Universidad de Sevilla.
Carlos spent 9 years in the laboratory investigating mineral transport in plants. He then started working as a freelancer, mainly in science writing, editing, and consulting. Carlos is passionate about learning the mechanisms behind biological processes and communicating science to both academic and non-academic audiences. He strongly believes that scientific literacy is crucial to maintain a healthy lifestyle and avoid falling for scams.

Click here to subscribe

RATE THIS ARTICLE

1 Star2 Stars3 Stars4 Stars5 Stars
(5 votes, average: 5.00 out of 5)
Loading...

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.