Evidence Based
11

Chronic Fatigue Syndrome Imbalances & Treatment Protocol

Written by Joe Cohen, BS | Last updated:

SelfHacked has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. We believe that the most accurate information is found directly in the scientific source.

We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic.

Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists.

Our science team goes through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again.

Our goal is to not have a single piece of inaccurate information on this website. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at [email protected]

Note that each number in parentheses [1, 2, 3, etc.] is a clickable link to peer-reviewed scientific studies. A plus sign next to the number “[1+, 2+, etc...]” means that the information is found within the full scientific study rather than the abstract.

People with chronic fatigue syndrome have high inflammation, unbalanced immunity, and low antioxidant status. Learn what to look for here.

Any kind of chronic inflammation will make you fatigued all of the time, so it may be hard to differentiate.

However, the first thing I look for is Th2 dominance, which is the immune profile in CFS.

What Causes CFS?

Chronic fatigue syndrome

It seems like CFS is a result of a viral infection and the body’s inability to control it. The result is oxidative stress.

This isn’t a post on how to combat CFS, but the general idea is to rebalance your immune system by increasing Th1, decreasing oxidative stress and reducing some kinds of inflammation.

This means that the mechanisms to control viruses are low and other kinds of inflammation might be high.

Your Doc Won’t Order These Tests

The problem is no doctor or will order these tests. As I understand it, doctors are under pressure from insurance companies and insurance companies are out for profit.

They don’t want to shell out thousands of dollars on tests if they don’t see a clear way to benefit from these tests.

People with CFS show elevated:

One must keep in mind that one test will not tell you if you have CFS. You need to take many of these tests to put a picture together.

People with CFS show decreased:

  • EPA [3]
  • Zinc [3, 16]
  • DHEAS [17] – contradictory [18]
  • Glutathione/GSH (cortical) [11]
  • Natural Killer Cell Activity/Cytotoxic activity of NK and CD8+T cells [5]
  • LPS-stimulated TGF-b [7]
  • HDL [2]
  • CD56bright NK cells [5] – CD56 Bright NK Cells are also lower in Coronary Heart Disease, Asthma, Rhinitis [19]
  • Granzyme A and granzyme K [5]
  • CD11b [8]
  • CD69 activation marker on T cells (CD3+, CD3+CD4+, and CD3+CD8+) and on NK cells (CD45+CD56+) – Since induction of CD69 surface expression is dependent on the activation of the protein kinase C (PKC) activation pathway, it is suggested that in CFS there is a disorder in the early activation of the immune system involving PKC [20].
  • DPPIV/C26 expressed on T cells and NK cells [21]
  • Neutrophil respiratory burst [22]
  • White matter in the midbrain [23]
  • PM Cortisol and 24hr urine free cortisol [24]
  • Folinic acid/Folate/Methylation [25, 26]
  • Bilateral white matter volumes [27]

Other

Gut Dysfunction – altered intestinal microbiota, mucosal barrier dysfunction [28].

Lesions in frontal white matter [29].

Corticotropin-releasing hormone (CRH) and neurotensin (NT), secreted under stress, activate mast cells (MC) necessary for allergic reactions to release inflammatory mediators that could contribute to CFS symptoms [30].

No difference in GPx [31].

“Almost every adolescent with CFS had orthostatic tachycardia (Stewart et al.,1999), but this was not the case with adults (Natelson et al., 2007) where rates appear to be lower ranging from 10% (Naschitz et al., 2006) to 27% (Hoad et al., 2008) with the higher rate found in UK patients who reported having the diagnosis of CFS rather than being directly diagnosed. In our own study of adult patients (Natelson et al., 2007), orthostatic tachycardia was not common, occurring in only 11% of patients, not significantly different from rates in healthy controls” [29].

“Finding subgroups of CFS suggests different underlying pathophysiological processes responsible for the symptoms seen” [29].

Want More Targeted Ways to Combat Inflammation?

If you’re interested in natural and more targeted ways of lowering your inflammation, we at SelfHacked recommend checking out this inflammation wellness report. It gives genetic-based diet, lifestyle and supplement tips that can help reduce inflammation levels. The recommendations are personalized based on your genes.

SelfDecode is a sister company of SelfHacked. The proceeds from your purchase of this product are reinvested into our research and development, in order to serve you better. Thank you for your support.

About the Author

Joe Cohen, BS

Joe Cohen won the genetic lottery of bad genes. As a kid, he suffered from inflammation, brain fog, fatigue, digestive problems, anxiety, depression, and other issues that were poorly understood in both conventional and alternative medicine.Frustrated by the lack of good information and tools, Joe decided to embark on a journey of self-experimentation and self-learning to improve his health--something that has since become known as “biohacking”. With thousands of experiments and pubmed articles under his belt, Joe founded SelfHacked, the resource that was missing when he needed it. SelfHacked now gets millions of monthly readers.Joe is a thriving entrepreneur, author and speaker. He is the CEO of SelfHacked, SelfDecode and LabTestAnalyzer.His mission is to help people gain access to the most up-to-date, unbiased, and science-based ways to optimize their health.
Joe has been studying health sciences for 17 years and has read over 30,000 PubMed articles. He's given consultations to over 1000 people who have sought his health advice. After completing the pre-med requirements at university, he founded SelfHacked because he wanted to make a big impact in improving global health. He's written hundreds of science posts, multiple books on improving health, and speaks at various health conferences. He's keen on building a brain-trust of top scientists who will improve the level of accuracy of health content on the web. He's also founded SelfDecode and LabTestAnalyzer, popular genetic and lab software tools to improve health.

Click here to subscribe

RATE THIS ARTICLE

1 Star2 Stars3 Stars4 Stars5 Stars
(2 votes, average: 5.00 out of 5)
Loading...

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.