Coffee May Cause Inflammation
Compared with coffee nondrinkers, people who consumed more than a cup of coffee/day had:
- 50-54% higher interleukin 6 (IL-6) 
- 28% higher TNF 
- 30-38% higher C-reactive protein (CRP) 
- 12-28% higher serum amyloid-A (SAA) 
The findings were significant even after controlling for age, sex, smoking, body mass index, physical activity status, and other covariates .
It can be argued that people with inflammation are more likely to drink coffee, but it’s widely enough consumed that I wouldn’t guess this to be the case, but it’s certainly possible – even though they controlled for important factors.
The effects on IL-6 seem to be confirmed in a randomized control trial in people with diabetes, which showed a similar 60% increase . On the upside, they increased adiponectin, which is a generally good thing for people who are obese/diabetic.
According to a review that looked at data from 18 studies with a total of 457,922 individuals, each daily cup of coffee was associated with a 7% reduced risk of developing type 2 diabetes .
Coffee seems to also help lower the risk of dementia/Alzheimer’s .
As far as the risk of death from all causes, coffee is associated with both slightly increased or decreased risk from death, depending on the dosage . For example, in men, 5-7 cups per week increased death risk by 2%, while 2-3 cups per day decreased death risk by 3%. However, 6 cups and over decreased death risk by 20%. Risks in women were different, but a bit better.
Coffee has pros and cons. The research is mixed as to its effects. While coffee has a lot of benefits, but we shouldn’t gloss over the negatives.
Coffee isn’t good or bad, as it affects everyone differently. It didn’t work for me, but try it for yourself.