Factors That Increase Klotho (Protein) + Gene Associations

Klotho is a protein that plays a role in intelligence and longevity. Read on to learn about genetic and environmental factors that may increase it.


What is Klotho (Protein)?

Klotho is a protein that circulates in the blood and brain throughout life. It declines with age, in conjunction with cognitive deficits [1, 2, 3, 4].

According to some research, it plays a role in longevity [5, 6].

It also helps regenerate muscle (by inhibiting TGF) [7].

People with genetic variants with higher levels of Klotho had lower rates of heart disease in one study [8].

Klotho suppresses insulin and IGF-1 pathways in mice. It suppresses the production of biologically active vitamin D (decreases 1alpha-hydroxylase) [9, 10].

Klotho may also enhance antioxidant balance [11].

Mouse Studies on Klotho

UPDATED 032414 Klotho Graphical Abstract

The below findings should guide further investigational efforts, but they should not be interpreted as supportive of any health effect of Klotho protein in humans.

According to the observations of some researchers, some mice bred for higher levels of Klotho:

According to other observations, some mice bred to have lower levels of Klotho experience: