In this post I discuss some of my experiments and biohacks I have tried, some have been great but some have been lackluster, over the years I have tried many new experiments and biohacks.
NOTE: My experiments are done to test substances at higher dosages so that I know they are safer for clients at lower levels and to feel the effects acutely. When done like this, I am fully aware that negative events are likely.
Over the years, I’ve done many of these experiments and many have gone wrong. Usually, it’s because I get impatient and want to test something more quickly. I generally don’t learn my lesson.
Anyway, my experience is good to help me understand these substances on a more visceral level, instead of solely through reading science articles.
I am 5X more cautious with clients than I am with my own body. It’s one thing that I mess me up, but it’s another if I mess someone else up. I feel if I mess myself up, then I’ll fix myself eventually (although this isn’t certain), whereas I can’t control someone else’s body.
My Experiment With CBD Oil
I didn’t find it very remarkable in the daytime, even though it was relaxing without being cognitively detrimental.
I tried vaporizing it and using it under my tongue. Both methods work, with the vaping working a bit better.
My Experiment Megadosing With L Rhamnosus
I tried first 10 caps of 5 billion organisms, then 20 on the second day and then 30 on the 3rd day, which finished the bottle.
So I took 150 billion organisms of L Rhamnosus. I didn’t take it alone and I can’t say that I experienced anything too significant.
This is the only probiotic that I megadosed that didn’t give me any gas. I feel like this one is a good one for me.
My Experiment With Megadosing L Acidophilus
I first took 10 pills the first day, 20 pills the next day and 30 pills on the last day, for a total of 60 caps in the bottle.
So I ingest a total of 300 billion organisms over 3 days or 150 billion on the last day.
It didn’t seem to do much. I’m not sure I even noticed a significant effect, but as opposed to some other experiments with probiotics, it didn’t give me gas…
There were many confounding variables, but given the fact that I didn’t notice a significant effect still says something.
Verdict: This is not a probiotic that I’m going to go out of my way to take, but it’s not bad for me. I would like my probiotics to have some of this.
My Experiment With Megadosing S. Boulardii and L. Plantarum
I’ve been trying to see which probiotics work for me individually.
I Love Adaptogens, But You Have to Use The Right Types
I’ve recently taken a strong liking to adaptogens, but this was only possible because you have to get the right types and know how to use it.
They can be taken no matter what your immune profile is.
I use them as more of a long-term enhancement thing. I notice they all regulate my hypothalamus well and they all potently improve mitochondrial function. The research supports this.
I’ve taken all of these in multiple forms, and I present the ones to you which I’ve gotten the best results from.
Notice they aren’t expensive either. Sometimes, quality costs a lot more, but not always. This is a case where the best stuff is relatively cheap.
All of these adaptogens work differently in my subjective experience and based on the research. So they can all be used together.
Schisandra is Great if You Get The Right Kind
I’ve tried Schisandra before, but the whole herb/berry. I found it made me fatigued, so I took it before bed for a while.
But it fell out of favor because it wasn’t a good tool for sleep or the daytime.
I’ve taken schisandrol A before, but it was too small of a dosage to notice. I will retry.
Anyway, I decided to try another version of it as a concentrated supplement form.
I was surprised at how well it works. It’s very relaxing, but not fatiguing at the same time.
Often the relaxers also cause some degree of fatigue, but not Schisandra. It’s actually a bit energizing.
I feel it has good cognitive enhancing, anti-depressant and anti-anxiety properties. And I must say it works somewhat uniquely, which is good.
The key is to get the right type. I used this Schisandra.
This will be a good addition to my toolkit. I need to take 2 caps to feel it noticeably.
Rhodiola is Great if You Know How to Use it and Which One to Buy
I first took Rhodiola about 6 years ago, but it kind of fell out of favor.
The reason it fell out of favor is because I used it without understanding how to use it and I bought a different version that I didn’t get a good effect from.
Rhodiola is also marketed as a performance enhancer, which I don’t find to be true, at least not while you’re on it. I can’t exercise as well and my mind is too relaxed for it to work when I used to cram for a test.
So I don’t recommend trying to use this as a performance enhancer in the short term, but it will increase your performance in the long run by normalizing your hypothalamus and increasing mitochondrial function.
So for these reasons, I stopped using it.
However, as my body has changed (less inflammation), my needs are also shifting.
For me, my main goal currently is to rebuild my mitochondria and Rhodiola is a very good molecule for that.
I also realized that the main molecule for this is salidroside and most only contain 1% salidroside. So I looked for the ones with the most salidroside and gave it a go. Indeed, these work very well for me.
It’s pretty relaxing, but not fatiguing at the same time. Often the relaxers also cause some degree of fatigue, but not Rhodiola.
I feel it has good cognitive enhancing, anti-depressant and anti-anxiety properties.
My experimental dosage was 1000mg Rhodiola (Amazon) and I found this to be a good dosage in isolation, actually. You probably want to take less if you’re stacking this. The linked Rhodiola has more than 3% salidroside.
On Iherb, I found these:
Rhodiola is a nice addition to my toolkit.
My Experiment With RiboGen
I decided to try RiboGen after a client mentioned that it worked for him.
RiboGen, a proprietary extract of the French oak tree and provides unique bioactive polyphenol compounds called roburins.
Roburins increase gene production of ribosomes, which are the small molecular factories in the cell that create proteins in the body.
In a human study, researchers found that RiboGen provided the following benefits:
- 18% reduction in weakness and exhaustion.
- 44% reduction in unrefreshing sleep.
- 33% reduction in head discomfort.
- 51% reduction in joint discomfort.
- 63% reduction in muscle discomfort.
I took 2 capsules of Ribogen and I’ve found it to be quite energizing. It has somewhat of a different mechanism of action as other supplements, so it’s a good addition.
I also felt that it worked uniquely, so I am excited about incorporating it into my toolkit – 1 capsule a day in the morning.
Buy: Ribogen (Iherb)
MSH Caused Cognitive Dysfunction
Nicotine is The Best Stimulant
I’ve been experimenting with nicotine in a few different ways – lozenges, e-cigarettes and various types of tobacco.
Nicotine is my preferred stimulant, as it doesn’t cause the same issues as caffeine.
It activates orexin and stimulates wakefulness. Nicotine is an incredible substance and is perhaps the best cognitive enhancer out there. The downside is that it’s addictive, which is why I support using it in a limited way.
There’s no scientific information on the Russian peptides, at least none that I’ve found.
However, I decided to give it a try for the heck of it. First I bought Endoluten, which was actually a mistake. I meant to buy cerluten instead.
Anyway, I couldn’t notice anything from Endoluten, even though I took like 8 pills. But I wasn’t sure what I was supposed to feel because I took it at night and went to sleep.
So I bought Cerluten and tried that out. I took 2 pills and didn’t notice much of anything. I took 4 and noticed perhaps slightly more, but still, I wasn’t sure.
At 6 pills, the effect became noticeable, with a subjective 95% chance that it had a good effect.
It was mostly relaxing, with some stimulation properties. It’s different than other stuff.
Usually, there’s a tradeoff with relaxation and decreased cognitive oomph. Cerluten doesn’t take the oomph out of your brain power, even though it’s relaxing. So it’s an excellent mix, which is hard to find in supplements and devices these days.
I feel more emotional, but it’s hard to know if that’s a natural fluctuation in my state or not.
I like it, but the question is if it’s worth it. I needed to take 6 pills to notice it to the extent that I was reasonably sure it was having an effect.
I’m glad I bought it and I’ll bet that some people will really benefit from it, but I don’t think I’m suffering from a Cerluten deficiency. I don’t think I’ll rebuy it, but you want to try it if you’ve got some cash to blow.
A confounding variable is that I took hi-maize, which hits the next day. I generally don’t like to take it when I’m experimenting.
UPDATE: I consumed 11 pills of it without confounding variables and I can say that it certainly does have an effect. However, 11 pills cause some cognitive dysfunction, as it’s just too much.
If you have money and you like self-hacking, then I’d suggest trying it out. If not, stick with other things.
PEMF is Powerful
I’m a fan of both top down and bottom up thinking with regard to solving problems.
Top-down would be to investigate the mechanisms and figure out what to do based on that, and I certainly am engaged in that fully and the book will discuss this in detail.
But at the same time, discoveries are made from a bottom-up approach, as a result of random experimentation. This is how Edison discovered the filament for light bulbs. LSD and some of the best drugs were discovered by accident.
So I bought the PEMF device without an idea of how it could help me. It was more of a bottom-up purchase.
I have not seen anyone use this device on their brain. Most devices are many thousands of dollars.
When I put it on my shoulder, I noticed a pretty strong and positive effect. Relaxing, wakeful promoting and feel good.
I finally got the guts to put it on the crown of my head. First I put it for 15 seconds total on my head, and I had a good effect.
I decided to put it on my head for 2 minutes total all over my head around the crown area.
It’s some pretty powerful stuff, and now I also know how it’s working, as it fits in with my new paradigm that I will be releasing in the book.
Anyway, just realize that it’s good stuff, but I can’t promise its long-term safety.
- VERY calming,
- Wakeful promoting,
- Temporarily impairs cognitive function – but only temporary. Goes away after a bit, but long term experiments are necessary to see how it affects cognitive function in the long term.
Right now, I’m only going to recommend using it not directly on the brain, since it’s really powerful. I recommend using it on your shoulder.
Buy: PEMF Device. If you’re in the US, you’ll need this converter as well.
UPDATE: I’ve found a device that has the same benefits, without the impaired cognition. Don’t buy this.
I’ve Been Successful at Chemically-Inducing Love (CINDLOVE?)
I’ve been experimenting with a cocktail of drugs, supplements and lifestyle factors that make me feel like I’m in love without actually being in love with a specific person. I am not romantically involved with anyone.
So yes, money CAN buy love – and it’s cheap 😉
Welcome to the 21st Century.
I am so fucking crazy.
I guess I’m going to have to divert it to mankind than to any specific person if I decide to keep it. I will reveal it soon if I see this experiment is repeatable.
My Experiment With Mega-Dosing Poppy Seeds
When you consume the whole seed, you get other synergistic components. I like it and will include it in my regimen. It tastes delicious.
My Experiment With Mega-Dosing Hydrogen Boost
I bought Hydrogen Boost with believing that it had a very low probability of working.
I took one or two capsules and didn’t really notice much.
Randomly, I decided to take it again, but this time 6 capsules. I can say that it certainly has a good effect.
I feel a cognitive sensation that feels somewhat similar to how I feel from other strong antioxidants, including C60.
I’d say C60 works more where it’s needed and it more long-lasting.
I’m going to incorporate Hydrogen Boost in my regimen and toolkit.
I bought this Hydrogen Boost. It contains Potassium Citrate, Silica, Potassium Carbonate, Oleic acid, and Hydrogen Negative Ions. I’ve tried the other ingredients and they don’t have this effect. It’s got to be the hydrogen ions.
I’d like to point out that the effect is more intense than hydrogen water, but I think they work in different ways.
My Experiment Mega-dosing Kidney Glandular
So I had bought kidney glandular a while ago for no particular reason. It was part of my approach to complete random experimentation.
Animal Kidneys are edible and I’ve eaten a decent amount of it before.
Anyway, I’ve taken 10 capsules of the glandular before as well, but I forgot how I felt off of it.
Instead of playing it safe, I decided to drop the rest of the bottle in the blender – must have been about 35 capsules. Did I mention that I get impatient and that I lack self-preservation instincts?
After 20 seconds, I felt a strong buzz and my kidneys started to hurt.
Kidney pain has subsided, and now a relaxing, but strong mental sensation has taken over. The mood is done and cognitive function is overall down. There’s a mix of fatigue and stimulation. There’s also GI effects like gas and stomach upset.
I wanted to see if anyone else had an experience with this and I found someone on Longecity who found 2 capsules every other day as too powerful. That’s BS, but it is quite powerful, at least the dosage I took. I’m not sure what the culprit is.
Kidney glandular supplements may contain:
- 1,25 Vitamin D,
- Atrial natriuretic peptide,
- Pregnenolone (R),
- DHEA (R),
- Androgens (R),
- Myo-inositol, sorbitol, betaine, and glycerophosphocholine,
I used this Kidney Glandular.
I recently tested soylent and expectedly I did not have a good result. I think it’s because of all the oat fiber lectins and somewhat because of the low-quality ingredients. I got some acne, felt cold, started to feel sick, was very irritable and it made me sleepy – all signs of inflammation. The verdict is NISHT. I don’t recommend it. Unfortunately, I will not be offering a competing product for at least 2 years.
I tested out the nasal desmopressin to see what vasopressin feels like. I read about vasopressin, but when you feel it viscerally, it creates a new perspective. I bought it 4 years ago and tried it, but I don’t think any made its way up my nose and I was afraid to take a real dose because I didn’t understand enough back then.
This was one of my more dangerous experiments, but my curiosity seems to be more powerful than self-preservation. It’ll probably get me in trouble one of these days. Anyway, it was quite interesting to feel what it was like.
It did increase orexin and wakefulness as the research suggests. It ruined my sleep and the next day caused some cognitive dysfunction. I don’t recommend it to anyone. The nasal spray has been implicated in two deaths due to hyponatremia or low salt levels. I made sure not to drink water and consumed adequate salt beforehand.
My Experiment Mega-dosing Fish Oil
I’ve recently experimented with a mega dose of EPA+DHA to see if the slight fatigue that I get from cod liver (only lasts for 10 minutes) has to do with just taking a high dosage of EPA+DHA. So I took 5 capsules and then 10 capsules for 2 days in a row.
I’d like to mention that I don’t perform my experiments as safely as I advise others to perform them. Curiosity is a dangerous thing for me.
I got some serious side effects. Bradycardia was one- my pulse dropped to a low of 40 but was hovering around 45. Second, my kidney or spleen started to hurt. Needless to say, I’m going to be halting fish oil for 2 weeks to get my blood thicker.
Anyway, I’m happy that I finally felt the effects of fish oil acutely. I will be taking about 1g a day in the long term.
My Experiment With High-Dose B12
I’ve been taking B vitamins for years but was never a big fan of the mega-dosing vitamins after studies came about beta-carotene and vitamin E.
When I did take B-12, I also took it with other B vitamins, so that’s a significant confounding variable.
What scared me away from mega-dosing B12, in particular, was my mother’s claim that she got neuropathy after taking really high dosages. I always figured that not much more was to be gained from going above the RDA.
In following my new strategy of testing everything in a high dosage at least once, I decided to revisit testing each B vitamin one at a time.
So I took a relatively modest dosage of Vitamin B12 (1.5mg or 25,000%) in the form of methylcobalamin.
Results: I became really sleepy for like 6 hours, but it was very relaxing. I was expecting it to be energizing, but I guess I’m going to start experimenting with it as a sleep aid. I also got a tinge of flushing and some random pains (very mild).
What’s interesting is that in a clinical trial of 23 people 3mg of methylcobalamin didn’t cause drowsiness in the daytime (R). If anything studies usually find that it increases alertness (R), so the effects were atypical.
I am almost certain that the B12 caused drowsiness for me since I took it in the morning, on an empty stomach and I stayed away from all food. I never get really drowsy on an empty stomach, especially after a good night’s rest.
This goes to show you that you can’t trust clinical trials on what will happen to you.
Another study detailed two case reports of people with sleep-wake cycles that were off and 1.5mg of B12 helped them (R).
It could be that those who experience a boost from it are deficient. I’m not sure.
After I got sleepy in the morning, I decided to take a mega-dose at night. My sleep was very interesting – overall better. It made me sleepy at night as well.
The negative was I had a benign nightmare of trying to pee and nothing was coming out. Bizarre. More experiments needed.
My Experience With a High Dosage of L-Histidine
I became really tired and weak. Cognitive function dropped. When I took my usual walk I became really weak. I think this is because L-histidine increases the amount of glycogen stored in the liver and my liver didn’t want to break down glycogen to give me glucose. It did feel like hypoglycemia.
My Experiment With Disposable Gloves For a #2
A few months back I thought of the idea to use disposable gloves when I go to the bathroom.
My Logic: Taking a dump is a messy/dirty business and I like to keep the natural anti-microbial oils of my skin. I don’t like washing my hands more than once or twice a day and I don’t like germs. And sometimes my hands smell even after washing it with soap. So I figured I’ll use disposable gloves.
My Results: I am very pleased with my experiment and disposable glove wearing will become an integral part of my toilet routine, which already includes baby wipes (if you don’t use baby wipes, you’re missing out). At about 10 cents a pop, the cost is certainly justified.
I wash my hands about once a day. However, I also don’t touch knobs to decrease my exposure to pathogens.
My Experiment With Niacinamide
I decided to experiment with 1500mg of Niacinamide AKA nicotinic acid. The point was to increase NAD+, as I get good results with Nicotinamide Riboside. Some people have gotten good results with Niacinamide.
- Fatigue – for the first 1.5 hours, mixed with energy
- Some very minor pains- for the first 1.5 hours
- A minor redness- for the first 1.5 hours
- Energy without fatigue after 1.5 hours, as I get from Niagen
Verdict: I’ll be using maybe 50 – 100mg of Niacinamide (Powder) a day. I don’t want to take this in high dosages.
You can try any dosage or brand of Niacinamide.
Both Niagen and nicotinamide are better for people with Th2 dominance.
My Experiment With MitoQ
The first day I took the recommended two pills or 5mg and felt nothing. On the bottle, they said do not exceed, but you know me 😉
The next day I took 8 pills or 20mg and DID feel something good. I would like to do more experiments, but these are effective.
The clinical trials use 80mg, so keep upping the dose safely if you’d like. All of the negative Amazon reviews are nonsense and mainly complain about how they didn’t feel anything off of 5mg.
It is expensive, but worth it, in my opinion, to cycle or perhaps take a low dose chronically – below the level, you can feel it.
I plan on taking 2.5mg daily. However, first, take a higher dosage to make sure that you feel positive benefits from it. First take 2, 8, 16 and 32 pills until you feel something. Once you do, you can take 1 pill chronically like I plan to do.
I’m actually in the middle of implementing a new protocol as I mine my genetic data, and MitoQ will be a part of it.
My Experiment Megadosing Malic Acid
So for two days this past week, I took a mega dosage of Malic acid – 9g or 15 pills of 600mg. I’ve taken half that dosage before without noticing much.
Malic acid was found to have life-extending properties (in worms), and it works in a few ways (R).
Malic acid converts to Oxaloacetate, which is pretty expensive, yet effective. I didn’t find it to have a very similar effect, but it wasn’t completely different either.
The point of the experiment was for a kind of toxicity study because I’m thinking about including maybe 500mg long term.
It caused some anxiety and perhaps worsened my cognition a bit, but overall nothing too bad. I think 500mg or 1/18th of what I took is a good dosage for me and I might include it in my regimen as a kind of hedge.