Evidence Based
4.4 /5
8

MMP9: Functions, Inhibitors, & Genes

Written by Joe Cohen, BS | Reviewed by Selfhacked Science Team | Last updated:

SelfHacked has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. We believe that the most accurate information is found directly in the scientific source.

We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic.

Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists.

Our science team goes through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again.

Our goal is to not have a single piece of inaccurate information on this website. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at [email protected]

Note that each number in parentheses [1, 2, 3, etc.] is a clickable link to peer-reviewed scientific studies. A plus sign next to the number “[1+, 2+, etc...]” means that the information is found within the full scientific study rather than the abstract.

MMP-9 is an important marker for those suffering from CIRS from Biotoxin/Mold exposure. However, it is also great for identifying inflammation associated with some of the most common chronic illnesses out there, including Autoimmune Diseases, Heart Disease, Cancer, and even chronic stress. But certain genes can make you more susceptible.

MMP9

MMP9 Functions and Why it is Important

MMP-9 is one of a class of zinc-dependent enzymes called Matrix metalloproteinases (MMPs), which are involved in the body’s natural process of tissue repair and replacement. MMP-9‘s protein breakdown properties help stimulate the immune response that initiates development and may exacerbate disease progression.

Physiologically, MMP-9 plays a role in normal tissue growth and repair processes such as neurite growth, embryonic development, blood vessel creation, ovulation, wound healing, and bone formation [1].

With this in mind, it is easy to see why one would want to encourage MMP9 when there is an injury, and want to inhibit it when inflammation is out of control or when cancer development is underway.

MMP9 Destroys the Blood-Brain Barrier (BBB)

Upon the induction of the neuroinflammatory pathway, MMP9 can break down the various components of the brain barrier: the Basal Lamina, Tight Junctions, and Extracellular Matrix [2, 3].

Inhibitors of MMPs have been shown to restore the Blood-Brain Barrier (BBB) integrity [4].

Conditions & Situations With Increased MMP9

All of the most common diseases have elevated MMP9, including a variety of autoimmune diseases, cancer, obesity, diabetes, and heart disease. This is because inflammation increases MMP9.

  • Cancer (in the blood) – including Breast Cancer [5]
  • Inflammatory diseases, includingCIRS (mold exposure)
  • IBD (Crohn’s, Colitis) [6]
  • Emotional Stress [7]
  • Obesity – Higher MMP-9 levels are found in obese subjects [8, 9] and MMP-9 is correlated with BMI [10].
  • Neuropathic pain – MMP9 is critical for neuropathic pain [11]
  • Heart disease (atherosclerosis, etc…). In heart attack models, MMP-9-deficient mice showed reduced rupture rate.
  • High blood pressure
  • Arthritis – in affected tissue [12]. The activation of MMP-9 production in tissue decreases collagen synthesis rates.
  • Diabetes
  • Multiple sclerosis – lesions are correlated with MMP9 levels [13]. In individuals experiencing an exacerbation of MS, MMP9 was found to be elevated in the spine [14]. Furthermore, treatment with an MMP inhibitor halted the progression of MS in animal models [15].
  • Alzheimer’s [16]
  • Lupus (in the blood) [12]
  • Sjogren’s (in tear-producing glands) [12]
  • Systemic sclerosis (in the blood) [12]
  • Polymyositis (MMP9 expression in certain tissue increased) [12]
  • Growth & Development
  • Wound healing

Conditions & Situations With Decreased MMP9

  • Delayed healing [17]
  • Insufficient immune response to infection [18]

MMP9 Inhibitors:

Supplements to inhibit MMP9:

Hormones to inhibit MMP9:

Pathways to Inhibit MMP9:

Drugs to Inhibit MMP9:

  • Atorvastatin [24], Pravastatin, and statins in general.
  • Prednisolone [63]
  • Doxycycline [64]
  • Minocycline [65]

Activators of MMP9

MMP-9 is secreted by a wide number of cell types, including neutrophils, macrophages, and connective tissue cells. Macrophages (the scavenger type of white blood cells) are a potent source of MMP-9.

Supplement/Equipment Activators of MMP9

  • IR/visible light spectrum of sunlight (in vivo) (74)
  • Manganese and boron (in test tube studies) [75]
  • Chitosan (enhanced activity of MMP-9 produced by macrophages with time) [76]
  • Fucoidan increases TNF-alpha induced MMP-9 [77]

No Impact:

MMP-9 SNPs

MMP-9 SNPs are strongly associated with obesity [80, 81].

SelfDecode has SNPs for MMP9:

  1. RS3787268 (MMP9) GG
  2. RS3918241 (MMP9) AT
  3. RS3918242 (MMP9)

Want More Targeted Ways to Combat Inflammation?

If you’re interested in natural and more targeted ways of lowering your inflammation, we at SelfHacked recommend checking out this inflammation wellness report. It gives genetic-based diet, lifestyle and supplement tips that can help reduce inflammation levels. The recommendations are personalized based on your genes.

SelfDecode is a sister company of SelfHacked. The proceeds from your purchase of this product are reinvested into our research and development, in order to serve you better. Thank you for your support.

About the Author

Joe Cohen, BS

Joe Cohen won the genetic lottery of bad genes. As a kid, he suffered from inflammation, brain fog, fatigue, digestive problems, anxiety, depression, and other issues that were poorly understood in both conventional and alternative medicine.Frustrated by the lack of good information and tools, Joe decided to embark on a journey of self-experimentation and self-learning to improve his health--something that has since become known as “biohacking”. With thousands of experiments and pubmed articles under his belt, Joe founded SelfHacked, the resource that was missing when he needed it. SelfHacked now gets millions of monthly readers.Joe is a thriving entrepreneur, author and speaker. He is the CEO of SelfHacked, SelfDecode and LabTestAnalyzer.His mission is to help people gain access to the most up-to-date, unbiased, and science-based ways to optimize their health.
Joe has been studying health sciences for 17 years and has read over 30,000 PubMed articles. He's given consultations to over 1000 people who have sought his health advice. After completing the pre-med requirements at university, he founded SelfHacked because he wanted to make a big impact in improving global health. He's written hundreds of science posts, multiple books on improving health, and speaks at various health conferences. He's keen on building a brain-trust of top scientists who will improve the level of accuracy of health content on the web. He's also founded SelfDecode and LabTestAnalyzer, popular genetic and lab software tools to improve health.

Click here to subscribe

RATE THIS ARTICLE

1 Star2 Stars3 Stars4 Stars5 Stars
(10 votes, average: 4.40 out of 5)
Loading...

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.