MMP-9 is an important marker for those suffering with CIRS from Biotoxin/Mold exposure. However, it is also a great for identifying inflammation associated with some of the most common chronic illnesses out there, including Autoimmune Diseases, Heart Disease, Cancer, and even chronic stress. But certain genes can make you more susceptible.
MMP9 Functions and Why it is Important
MMP-9 is one of a class of zinc-dependent enzymes called Matrix metalloproteinases (MMPs), which are involved in the body’s natural process of tissue repair and replacement. MMP-9‘s protein breakdown properties help stimulate the immune response that initiates development and may exacerbate disease progression (R).
Physiologically, MMP-9 plays a role in normal tissue growth and repair processes such as neurite growth, embryonic development, blood vessel creation, ovulation, wound healing, and bone formation (R).
MMP9 Destroys the Blood Brain Barrier (BBB)
Inhibitors of MMPs have been shown to restore Blood Brain Barrier (BBB) integrity (R).
Conditions & Situations With Increased MMP9
- Cancer (in blood) (R) – including Breast Cancer (R)
- Inflammatory diseases, including CIRS (mold exposure) (R)
- IBD (Crohn’s, Colitis) (R)
- Emotional Stress (R)
- Obesity – Higher MMP-9 levels are found in obese subjects (R, R2) and MMP-9 is correlated with BMI (R).
- Neuropathic pain – MMP9 is critical for neuropathic pain (R)
- Heart disease (atherosclerosis, etc…) (R). In heart attack models, MMP-9-deficient mice showed reduced rupture rate (R).
- High blood pressure (R)
- Arthritis (R) – in affected tissue (R). The activation of MMP-9 production in tissue decreases collagen synthesis rates (R).
- Diabetes (R)
- Multiple sclerosis – lesions are correlated with MMP9 levels (R). In individuals experiencing an exacerbation of MS, MMP9 was found to be elevated in the spine (R). Furthermore, treatment with an MMP inhibitor halted the progression of MS in animal models (R).
- Alzheimer’s (R)
- Lupus (in blood) (R)
- Sjogren’s (in tear producing glands) (R)
- Systemic sclerosis (in blood) (R)
- Polymyositis (MMP9 expression in certain tissue increased) (R)
- Growth & Development (R)
- Wound healing (R)
Conditions & Situations With Decreased MMP9
Supplements to inhibit MMP9:
- Curcumin (R, R2, R3)
- Resveratrol (R)
- Berberine (R)
- Tea/EGCG (R, R2)
- Andrographis (R)
- Fish oil (rats) (R)
- Forskolin (R)
- Ginger (R, R2)
- Magnesium (R)
- NAC (in test tube studies) (R)
- Glycine (R)
- Baicalin (rat model) (R)
- Ursolic acid (R)
- DIM (R)
- Adenosine (by neutrophils) (R)
- Capsaicin (R)
- Carnosine (R)
- Cranberry (flavonoids) (R)
- Proanthocyanidins (bilberry, green tea, black tea, black currant) (R)
- Apigenin (flavonoid) (mice) (R)
- Apple polyphenol (in test tube studies) (R)
- Pomegranate (R)
- L-arginine (R)
- Grape seed extract (R)
- Inositol (R)
- Astragalus and Panax Ginseng (R)
- Holy Basil/Tulsi (ocimum sanctum) essential oil (R)
- Caffeine (R)
- Hydroxytyrosol (R)
- Broccoli (R)
- Watercress (R)
- Lycopene (R)
- Ecklonia cava (R)
- Angelica gigas/decursin (R)
- Boswellia/Frankincense (Boswellia frereana) (R)
- Chinese Hawthorn (Crataegus pinnatifida) (R)
- Matrine (alkaloid from plants of the pea family) (R)
- Nobiletin (a citrus flavonoid) (R)
- Silver (for wounds in test tube studies) (R)
Hormones to inhibit MMP9:
Pathways to Inhibit MMP9:
- Inducing tolerance of toxins (R)
- Interferon Gamma (Th1 cytokine) (R)
- PPARgamma (R)
- Nf-kB inhibitors (R, R)
- ACE inhibitors (R)
- Angiotensin receptor inhibitors (R)
- Aldosterone inhibitors (R)
- Beta blockers (R)
- TIMP-1 (R)
- SIRT1 (R)
- STAT3 inhibitors (R)
- AP-1 inhibitors (R)
Drugs to Inhibit MMP9:
- Atorvastatin (R), Pravastatin (R), and statins in general.
- Prednisolone (R)
- Doxycycline (R)
- Minocycline (R)
Activators of MMP9
MMP-9 is secreted by a wide number of cell types, including neutrophils, macrophages, and connective tissue cells (R). Macrophages (the scavenger type of white blood cells) are a potent source of MMP-9 (R).
- Psychological, emotional stress and activation of the nervous system (R) – causes neutrophils to release MMP9.
- Fungal toxins (T-2 toxin) (R)
- Amyloid beta (R, R2)
- TGF beta1 (R)
- VEGF (R) – MMP-9 also increases VEGF (R).
- NGF (potentiates) (R). MMP9 also potentiates nerve growth factor neurite growth (R)
- Angiotensin II (via Nf-kB, EGF and MAPK) (R)
- Aldosterone (via NF-κB) (R)
- Osteopontin (R)
- Nf-kB (R)
- Reactive oxygen species (ROS) (via NF-κB) (R)
- IL-1b (R)
- TNF (R) – especially potent
- Other MMPs, including MMP-2, -3, -13, -17, and -26 (R, R2, R3, R4)
- Plasmin (R)
- Urokinase-type plasminogen activator (uPA) (R)
- Tissue-type plasminogen activator (R)
- Heat shock protein 60 (HSP60) (in white blood cells) (R)
- Epidermal growth factor (EGF), basic FGF (connective tissue growth factor), PDGF (Platelet derived growth) (R)
- All protein degrading enzymes released from neutrophils promote MMP-9 activation (R)
Supplement/Equipment Activators of MMP9
- IR/visible light spectrum of sunlight (in vivo) (R)
- Manganese and boron (in test tube studies) (R)
- Chitosan (enhanced activity of MMP-9 produced by macrophages with time) (R)
- Fucoidan increases TNF-alpha induced MMP-9 (R)
Health Tools I Wish I Had When I Was Sick
At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on pubmed to figure out how the body worked and how to fix it.
That’s why I decided to create tools that will help others cut down the guesswork:
- Lab Test Analyzer – a software tool that will analyze your labs and tell you what the optimal values are for each marker — as well as provide you with actionable tips and personalized health and lifestyle recommendations to help you get there.
- SelfDecode – a software tool that will help you analyze your genetic data from companies such as 23andme and ancestry. You will learn how your health is being impacted by your genes, and how to use this knowledge to your advantage.
- SelfHacked Secrets – an ebook where we examine and explain the biggest overlooked environmental factors that cause disease. This ebook is a great place to start your journey if you want to learn the essential steps to optimizing your health.
- SelfHacked Elimination Diet course – a video course that will help you figure out which diet works best for you
- Selfhacked Inflammation course – a video course on inflammation and how to bring it down
- Biohacking insomnia – an ebook on how to get great sleep
- Lectin Avoidance Cookbook – an e-cookbook for people with food sensitivities
- BrainGauge – a device that detects subtle brain changes and allows you to test what’s working for you
- SelfHacked VIP – an area where you can ask me (Joe) questions about health topics