VEGF plays a role in heart disease, cancer, chronic inflammation, depression, tissue oxygenation, cognitive function, kidney disease and macular degeneration. VEGF can be harmful at high or low levels.
What is VEGF?
VEGF (Vascular Endothelial Growth Factor) is a protein that initiates blood vessel formation.
VEGF Helps Oxygenate Tissue (by Creating New Blood Vessels)
VEGF leads to creation of blood vessels in the unborn baby (R).
VEGF makes blood vessels bigger which means more blood flow (R).
Part of the mechanism by which it leads to new blood vessel formation is by increasing MMPs (R).
VEGF Can Benefit Heart Disease (by Creating New Blood Vessels)
The VEGF gene can be injected into cells to make them produce more VEGF (R).
This will make new capillaries grow, and will help bypass blocks in blood vessels caused by plaque (R).
VEGF Helps Immune Function
VEGF outside the blood vessels attracts immune fighter cells (R).
VEGF builds lymph vessels, which are important for immune cells as they move through your body, looking for dangerous bacteria, viruses, and fungi (R).
The negative to this is that it can increase inflammation.
VEGF Protects the Brain
VEGF can help prevent brain impairments by improving neuron function and viability (R).
VEGF May Increase Inflammation by Activating Microglia
VEGF Leads To Holes In Blood Vessels To Make Them More Leaky
VEGF removes molecules that makes blood vessel cells stick to each other (like different sections of a pipe are held together with screws). This makes blood vessels leaky (R).
VEGF can increase permeability of the blood brain barrier (R).
VEGF Contributes to the Spread of Cancer
By making it easier for cancer cells to grow, it makes it harder to destroy cancer cells (R).
VEGF Worsens Some Autoimmune Diseases
VEGF causes fluid to leak out of blood vessels by making them leaky (R).
Blood levels of VEGF correlate with disease activity in a large number of autoimmune diseases and fall with the use of standard therapy.
VEGF Makes Diabetic Retinopathy and Macular Degeneration Worse
These new blood vessels are fragile, and can burst, leading to blood leaking out and damaging the back of the eye where light is transformed into a picture (R).
VEGF Causes Kidney Damage
VEGF builds blood vessels in the kidneys (R).
Kidney cells, which are filters through which fluid from blood is sieved through eventually cannot take that much fluid coming through them and are destroyed (R).
This leads to everything going through the filter as it is now destroyed (R).
This kills kidney cells, and makes the urine have things it shouldn’t have like protein (R).
VEGF changes can indicate early-onset pre-eclampsia which can cause miscarriages (R).
VEGF Contributes to Depression
This is due to the fact that VEGF influences the level of neurotrophins in the brain. VEGF can also mimic the actions of antidepressants, causing them to not work (R).
VEGF Activates Matrix Metalloproteinases (MMPs)
- Andrographis (in-vitro) (R)
- Curcumin (R)
- Tea/EGCG (found in green tea) (R)
- Anthocyanins (found in berries, grapes, eggplants, sweet potato, mango, etc.)
- Fish oil/DHA
- Polyphenols (found in tea, olive Oil)
- Luteolin (found in broccoli, pepper, thyme, etc.) (R)
- Lycopene (found in tomatoes, beans, asparagus, etc.) (R)
- Ubiquinol (R)
- Naringenin (found in grape fruit) (R)
- Myricetin (found in sweet potato, currants, cranberries, etc. ) (R)