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“And those who were seen dancing were thought to be insane by those who could not hear the music.”

-Nietzsche

Executive Summary: Top Picks To Become Tolerant and Fix Autoimmune and Inflammatory Disease

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I realize most people won’t make their way towards the bottom of the post, but this is really where this part belongs. Anyway, to understand why this works and for references, read on.

Note that there are many different types of intolerances resulting from different immune imbalances.  I tried my best to give a general approach.

Step 1: Create dietary and lifestyle conditions for oral tolerance

You’re going to want to avoid Lectins with diet, or even better go on an elemental diet if you can. 

You’re also going to want Sun and if not use  a UVB light.  Some exercise is great, too.

Intermittently having a low protein diet is also a good idea.

Eat animals – all parts of the animal. Means don’t only eat the breast.  Eat the whole chicken, including the marrow in the bones, the cartilage, etc…  If you’re a vegan/vegetarian then I wish you luck trying to heal your autoimmune/inflammatory issues.   I have nothing against these diets if you supplement right and don’t have inflammatory conditions.

As far as foods DHA is an absolute mustBlack Cumin Seed Oil  and Extra Virgin Olive Oil can help, too.

Hi-maize resistant starch is also a must.

I’m not saying Resistant Starch will work for everyone because it does have some immune stimulating components – and it’s not even perfect for me, but it’s still good.   Scroll to the bottom to see how it affects the immune system.

Step 2: Take These Important Supplements

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Yes, take all of them, especially when you’re ingesting the protein you want to become tolerant to.  Experiment with one at a time before you stack these.

Step 3 for Autoimmune Conditions: Use Glandulars and LLLT

For autoimmune conditions, put LLLT on your intestines.

Then ingest the following glandulars, depending on your condition:

Hypothalamus, Adrenal, Thymus, Spleen, Thyroid, Liver, Pituitary, Pancreas, Brain, Stomach.

You want to take a high dosage of these.  There’s no harm in taking all of them if you’ve got a system autoimmune condition.

Step 3 For Food Allergies

Ingest a very small dosage of the allergen and keep working up.  If you have a reaction you’ve taken too much.

Alternatively, you can take a high dosage if you’re not in danger of anaphylactic shock.  See the above picture regarding the effects of ingesting a low or high dose.  The immune effects are different.

It’s Irrelevant Whether This Works By Oral Tolerance

This is a great regimen for autoimmune disease, even if it’s not actually helping you by creating ‘oral’ tolerance.

Oral tolerance is meant to nudge your disease so that you heal quicker.

The recommendations here generally are great for autoimmune conditions, regardless.

For example,  even without anything else lectin avoidance can cure autoimmune disease and inflammation. (R)

Why Isn’t This Stuff More Well-Known?

There’re a few reasons why you don’t see this information anywhere else:

1) The information is relatively new.

2) Much of the information is buried in the scientific literature and sometimes read by a total of 100 people (one interesting study I found had about 100 views. Seriously.)

3) The people who do read it don’t have the same self-hacking approach that I have.  They have more of a stodgy, narrow, old-school mindset.

4) People don’t understand the gamut of supplements and devices available to manipulate our biology.  In this age of specialization people only see through a tiny lens.

5) People haven’t experimented with the supplements on themselves.  I can tell you it’s a world of a difference reading a scientific paper about some substance and taking it.  My experiments are invaluable in helping me understand how things work and meshing it with the science.  Without these, my understanding would be much more limited.

Keep in mind, though, that it’s unknown how well my theoretical framework will work in practice.  You need to experiment for yourself.  All I’m presenting is a theoretical framework and some direction.

Use the comments section to let others know about your experience.   And please give a detailed account what you did and your immune system background.

I think it will be quite effective, but the degree will depend on your condition, how smartly you create a regimen, how diligent you are with keeping it, etc…

The biggest problem I see in people that don’t get better is being timid.  People are scared to take big moves and get out of their comfort zones.  We are an afraid species.   We’re afraid what may happen, what people will think, etc…

I’ve tried out everything mentioned here with no side effects, so it’s all relatively safe if used right.

What Does it Mean To Be ‘Tolerant’?

Tolerance simply means that your immune system tolerates a protein and doesn’t attack it with inflammation.

This protein could be one that is a part of your body, such as thyroid peroxidase or myelin basic protein.  Your body attacks these proteins in thyroiditis or multiple sclerosis, respectively.

Alternatively, your body can attack a food protein, such as gluten, casein or any other protein found in foods.

Can We Become Tolerant to Lectins?

My current thinking is as follows:

Studies use the lectins PHA and ConA to see what our immune response is like.   This is standard immunology practice.  So lectins are inherently immune stimulants, just as LPS is (a bacterial substance). This is not a matter of simply being intolerant to a protein.

Why it affects people differently is because of the genetic make of our immune system (and environmental influence).

Most people don’t experience significant effects from dietary lectins, but lectins are to be taken seriously if you have inflammation for no reason and your diet and lifestyle is healthy.

If lectins are not balancing your immune system, then that will cause you to become intolerant to various proteins.

With greater understanding, I’ve been able to combat lectins in various ways and disable the immune response, but so far none of the solutions are cures or free of side effects.

A combination of all of the tools can surely make a massive difference, but again, no silver bullet yet.

The best subjective anti-lectin agents I’ve found so far are:

  1. Sialic Acid
  2. NAG
  3. Mannose
  4. Kombucha
  5. EDTA
  6. HCL with pepsin

And then there’re hundreds of ways to dampen the immune response.  See how to fix Th1 dominance and Th2 dominance.

What is ‘Oral Tolerance’?

Oral tolerance is when you ingest a given protein and you become tolerant to that protein.

Think about this in terms of evolution.  If you chronically ingest a given protein or ingest a very large dosage of said protein, it would be advantageous for you to develop a tolerance and not attack it.

This is because, in both situations, the likely scenario is that we wouldn’t be eating a huge amount of a pathogen or chronically ingesting it.

If we’re only exposed to certain kinds of foods, we ‘d be more likely to survive if we could build a tolerance to it.

Tolerance to ingested proteins is essential for the barrier function of the intestinal tract i.e. to prevent leaky gut. (R)

Breakdown of tolerance is associated with the development of chronic inflammatory diseases, such as Crohn’s disease and ulcerative colitis, as well as food allergies and celiac disease. (R)

Though the mechanisms aren’t completely understood, oral tolerance works by deactivating T and B cells that target our tissues – either by getting rid of them or by making them not respond to proteins anymore (clonal deletion and anergy).  The other mechanism is by Tregs directly suppressing these cells (R).

In autoimmune disease research, the goal of oral tolerance is to suppress the Th1/Th17 response (for most autoimmune diseases).

There are two ways that researchers try to create oral tolerance.   The first is by giving a high dose of a protein once.  The second is by ingesting the protein at a lower dosage multiple times, which is supposed to increase Tregs.  The multiple dose approach is more suited for autoimmune disease. (R)

What is Required For Oral Tolerance?

 Diagram of the layers of the intestinal wall

Creating tolerance for one kind of condition can be very different for creating tolerance in another.

For example, creating tolerance to peanuts in IgE-related allergies (Th2 dominant) is very different than creating tolerance in a condition that is Th1 dominant.  In fact, the treatments could oppose each other.

Creating tolerance is difficult, but there is some data that it can be effective for some people. Indeed, sometimes people spontaneously develop tolerance to foods over time. (R)

Intestinal tolerance requires Tregs and T cells in the intestines (lamina propria). (R)  Specifically,  the Tregs that are created (iTreg) are required for tolerance (as opposed to thymic Tregs). (R)

Vitamin A plays a fundamental role here. Vitamin A is converted to retinoic acid (in peyer’s patches), which encourages T Cells to travel to the gut. (R) (by displaying proteins on the cells α4β7 and CCR9, which allows it to roll there.)

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Some types of immune cells found in the gut (CD103+ DCs) were recently found to take in proteins through intestinal cells.

These immune cells then migrate to lymph nodes in the gut and communicate with T Cells.

With the help of some other molecules (TGF-β, retinoic acid, IDO), these cells then program the T Cells to become Tregs. (R)

These Tregs then proliferate in the gut and suppress the local immune response, which means we won’t respond to food proteins. (R)

In particular, TGFb and IL-10 seem to be crucial for creating tolerance by Tregs. (R)

Lymph nodes are all over the body and are connected to each other.  They are simply a place where immune cells congregate.

Eventually, it’s thought the immune cells travel through the lymphatic network and communicate with other immune cells and tell them that a given protein is cool.

The enzyme that converts Tryptophan to 5-HTP (Tph-1) is also needed to create tolerance, but the tolerance effects are not because of serotonin. (R)

The Dark Side of Tolerance

Realize that it’s mostly the case that the more our system is geared towards tolerance of various proteins, we are also more likely to become tolerant to cancer cells.

So when there is a deficiency of the Tph-1 enzyme, it causes inflammation because we lose tolerance, but it also causes tumors to stop growing.  (R)

We want our body to become intolerant to cancer cells, but tolerant to our healthy cells.  So there’s usually some kind of tradeoff involved.

Much research speaks about cancer/autoimmune tradeoff.

Some Supplements/Factors That Help Create Tolerance

  • High doses of the allergic protein (R) – This is best to create immune unresponsiveness in Th1 dominance type allergy (causes IL-4 release). (R)
  • Low doses of allergic protein (R) – This leads to the release of TGF-beta.
  • Hi-Maize resistant starch/Butyrate (RR2) HDAC(-) (R).   Initially, HDAC inhibitors were thought to be predominantly immunosuppressive, but more recent reports have challenged this view. (R)  See butyrate’s effects on the immune system.
  • Thymus glandular (R) – The thymus is the origin of a population of ‘natural’ Tregs.  I would try this out as people do find it helpful for autoimmune conditions and it’s got some animal study support. (R) I found it to be quite an immune stimulant and care should be taken with Th1 dominant folks.
  • Whey (R) -induces oral tolerance in Th1/delayed food sensitivities.  I do better without whey, overall, but it helped when I was still eating lectins.
  • Fish oil is rich in ingredients that help tolerance: DHA (R, R2), Vitamin A (R), Zn (R), Vitamin D3 (R),
  • VIP (R) (found in Hypothalamus, Stomach, Pancreas)
  • Breast milk (R),
  • Low Protein diet (R) – for Th2 dominance/IgE and IgG allergies (decreases IL-4).
  • Chitosan  (R2),
  • Probiotics: L casei (R), L lactis (R), B infantis (R),
  • Curcumin (R),
  • Ursolic acid (R) – this is interesting when it comes to tolerance because it doesn’t function via Tregs.  Rather, it gets rid of the T cells which attack our body.

Others, unobtainable:  Sublingual antigen attached to cholera toxin B (R), E coli (R),  D,L-PLG microspheres (R), IgA (R) – in early life? (stomach, lung), Salbutamol (R), Ephedrine(beta-2 adrenergic agonist), PLGA (R), E coli (R)

Mechanisms That Influence Oral Tolerance

I’ve compiled a list of mechanisms that influence oral tolerance and some ways to influence these mechanisms.

Tregs and Tolerance

Tregs are critical for creating tolerance and are by far the most important aspect.  See my post on how to increase Tregs.

IL-10 and Tolerance

IL-10 seems to be crucial for tolerance induction by Tregs. (R)

I recommend reading through my post on IL-10.

TGF Beta and Oral Tolerance

Studies have shown that TGFb in the gut area is necessary to create tolerance orally. (R)

TGF-beta also leads to the death of T cells that attack our tissue (clonal deletion). (R)

See my post of TGF and how to increase it in the intestines.

Inflammation, Nf-kB and Oral Tolerance

NF-κB activation prevents oral tolerance from occurring.  This is because of the proinflammatory cytokines in the gut area. (R)

Indeed, TNF, IL-1 andIL-6 block the ability of Tregs to induce tolerance. (RIL-17 also blocks the creation of tolerance, in part by increasing IL-6 (R).

I highly recommend reading through those posts to see why these cytokines might be out of whack for you.

Some supplements can increase Nf-kB in the gut such as Lithium (R) and Goji berries (R). You want to stay away from these.

As long as you are having a source of inflammation, it will be very difficult to build tolerance.

If you have lectin sensitivity and you are consuming lots of lectins, it will be tough or impossible to create tolerance.

 Read my posts to understand the factors that influence NF-kBTNF, IL-1 , IL-17 and IL-6.

Interferon Gamma and Oral Tolerance

Interferon gamma is a Th1 cytokine.

In people with IgE-related allergies (peanuts, etc…), giving Interferon gamma with the allergic protein got rid of these allergies.

All 5 people given the interferon were cured of their IgE allergies, while none of the 5 people who weren’t given it were cured.  (R)

The way you would go about this without interferon itself is to rebalance your Th2 dominant immune system and then introduce tiny amounts of the antigen.

Germanium is pretty effective at increasing interferon-gammaR).  My bet is Thymus glandular works as well (R). If you have a serious and potentially fatal allergy, then you want to do this in a medical setting and try to get the interferon itself.

Interferon won’t create tolerance in non-IgE allergies and it could worsen your condition if you’re Th1 dominant.

IL-12 and Oral Tolerance

IL-12 is part of a Th1 response, so supplements that generally increase Th1 will elevate IL-12, but this isn’t always the case.

IL-12  blocks oral tolerance, at least in colitis and likely other Th1 dominant conditions. (R)

By inhibiting IL-12, we can create conditions more suitable for oral tolerance.

Since I don’t have a dedicated post to it, here’s some factors that decrease IL-12:

Factors that increase IL-12: Nucleotides (R), JAK-STAT (R)

Dendritic Cells and Oral Tolerance

Dendritic cells, in general, are critical for immune tolerance – to our own proteins as well.  When we have a low level of stimulating molecules on these immune cells, it’s thought that the body learns to stop responding to the protein it was programmed to attack.  (R, R2)  These stimulating molecules on the surface of dendritic cells can also help this immune response, making them bad in two ways. (R)

When the clearance mechanism of cells isn’t working well, the proteins in these cells build up.  As  a result of the abundance, the dendritic cells start to consume these proteins,  which results in a programmed immune response against them and thus our own tissue. (R)

Probiotics help create more of the variety of dendritic cells that can help us create tolerance.

The following are good for increasing these dendritic cells: L Salivarius, L Plantarum,  L Lactis (R).

Intestinal Mucus and Oral Tolerance

The mucus of our gut forms a barrier so that stuff doesn’t go through.   Recently, it was found that this mucus barrier was also important for creating oral tolerance and suppressing the gut immune system. (R)

Now, if your mucus barrier is fine then I don’t know if making it stronger will have any effect.  But the point is to make sure that your mucus barrier is fine…

The following increase intestinal mucus:

  • Gum  – the process of chewing increases intestinal mucus.
  • Colostrum (contains TGFb)
  • Antler velvet (contains TGFb)
  • Artichoke (R),
  • Slippery elm (R)
  • DGL (R),
  • Collagen (R),
  • Sialic Acid and NAG perhaps – both are building blocks of the mucus.
  • Bile (R)...Bile Acid Conjugates/TUDCA,  or Liver (These also increase bile: T3, Time Restricted eating, Melatonin, Curcumin, Ginger, Cumin, Curry, Garlic, Licorice,  Silymarin, Nettle, Peppermint, Berberine,  Artichoke, Celery, Caffeoylquinic acids, Andrographis)
  • Quercetin glycoside (R),

Others, but not recommended for this purpose:  Whey (R), Tulsi (R), Amla (R), Black Cumin Seed Oil (R) – contradictory (R)

Oxidative Stress and Tolerance

Oxidative stress/ROS  actually help Tregs suppress immune activation.

Particularly, NADPH oxidase is important (produces superoxide).  In fact, Tregs are able to suppress the secretion of cysteine in order to suppress the immune response. (R)

This puts a damper on NAC and Spirulina, both of which inhibit the oxidant in question.

So, do not take NAC and Spirulina while trying to create oral tolerance.

If you aren’t actively trying to do so, then you can take them without an issue.

NAC is quite useful for autoimmune diseases (R), so it’s good to take it.

Just don’t take it during an 8 hour period that you are trying to create tolerance.

Forskolin, cAMP, and Tolerance

cAMP is a very popular molecule that is used to communicate messages in the cell.

cAMP molecules in T Cells relay the message to not activate or proliferate in response to a protein. (R)

It sends the message that all is cool with whatever protein is presented to T cells.  (R)

This results in a situation where the immune cells learn to become unresponsive to proteins. (R)

Forskolin is a supplement used in research to increase cAMP (R).

It goes well with Luteolin because it inhibits an enzyme (PDE4) that breaks down cAMP.  This results in more cAMP for longer periods.

Adrenal glandular and ephedrine also increases cAMP via Beta-2 adrenoreceptor agonism (R).

Surface Molecules and Oral Tolerance

‘CD’ and some number just refers to a protein that’s lodged on the surface of an immune cell.   These proteins are an important aspect of immune system communication.

CD80

CD80 is a protein that immune cells need for communication.  This protein is needed to create and sustain tolerance.  When it’s blocked oral tolerance and tolerance of our own tissue is blocked as well.  This protein is also important to make cells unresponsive when challenged with the allergic protein. (RR2)

In order of power: L Lactis (R) (powerful), L plantarum (R), L salivarius (R) (not powerful), – all in Gut…….. L. plantarum (R), spleen.

CD103

CD103 is a protein found on immune cells (dendritic cells) that hang out by our intestinal surface.  These cells can communicate with the proteins we ingest with a tentacle-like structure.  

These cells, with the CD103 protein, are necessary for oral tolerance (R).  It’s only cells with these proteins that create special types of Treg cells when TGF was present (Foxp3). (R)

Probiotics such L Salivarius, L Plantarum,  L Lactis can help in that order (R)  The Probiotic B Breve helps the cells with CD103 create tolerance (by stimulating their production of IL-10 and IL-27). (R)

CD40

CD40 is a protein on immune cells and its purpose is to stimulate it i.e. cause inflammation.  It blocks us, to a degree, from creating immune tolerance  (R).

The following inhibit CD40 and it happens to be I’m a fan of all of these supplements:

Things That Block Tolerance

  • Citrus pectin (R), Palmitate (R), Retinoic acid+IL-15 (R), Skin sensitization (R), Alginate (R), Appendectomy (R), Thymectomy (R), Alcohol-induced gastritis (R), H Pylori (R), MCT (for Th2 dominance) (R)

Diseases And Oral Tolerance

First, you want to set the stage for creating oral tolerance by implementing the above measures that I’ve described.

Once all systems are in place, you then ingest a protein that your body is attacking.

You can try to get any protein they use in the scientific literature.  It’s just expensive and going to be hard to obtain.

I’ve tried all of the glandulars.

Rheumatoid Arthritis

As we know, this is a disease that attacks our joints. Therefore, I recommend ingesting Collagen.

Life extension claims that commercial collagen is denatured and that only this Collagen type 2 can create oral tolerance.  It also cites studies that show it survives the GI tract and creates oral tolerance in people (R).

Multiple Sclerosis

In MS, myelin is attacked.

Chronically feeding mice low doses of the myelin basic protein stopped MS in its tracks through the production of Tregs (via TGFb) (R, R2).

I recommend Sphingolin or Brain glandular.

Hashimoto’s and Graves

Thyroid proteins are attacked in these conditions.

You want to ingest Thyroid glandular.  Make sure to get one without thyroid hormones in there.  It does have significant amounts of iodine, however, based on my experience…

Colitis, Crohn’s

Intestinal tissue is attacked in Colitis and Crohn’s.

Studies use ‘Haptenized Colonic Protein’ for Colitis (R).

But until this cool sounding protein becomes mass market, you might want to try Stomach glandular.

Type 1 Diabetes

In Type 1 diabetes, pancreatic cells are attacked.  You want to ingest Pancreas glandular.

Pancreas glandular contains insulin, but it gets digested and doesn’t function the same way as when you inject it.

Ingesting insulin itself has some interesting effects such as increasing TGFbeta (R).  I wouldn’t expect this since much of it gets digested.

Addison’s

Addison’s disease is an autoimmune condition where your adrenals are attacked and destroyed, resulting in very little cortisol being produced.

I recommend taking Adrenal glandular.

Systemic Autoimmune Diseases

SLE/Lupus is an example of a systemic autoimmune disease that attacks a certain protein in the nucleus of our cells.  For a disease such as these, I would recommend just ingesting animal based foods and excluding plant-based foods, except leafy greens or Sauer kraut.

Animal foods have much of the proteins that we have.  Don’t just stick to one part of the animal such as the muscle, but instead, eat as much of the animal as possible.

When I buy a chicken I eat the cartilage, the marrow in the bones, the bits of organs found inside, the skin, the ends of the bones, etc.. Barely anything is left when I’m done with it.

When you buy a steak, you’re only eating the muscle.  This is fine in moderation, but it’s better to diversify.

Others

I’m not going to give the full gamut of autoimmune diseases here, but the point is you should research exactly what part of the body is being attacked and ingest those proteins from animals.  The proteins are similar enough to ours to have an effect.

Disclaimer and Caveats

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37 COMMENTS

  • Marie

    Any results so far?

  • Rosa Yohanan

    Hi,
    I would like to know how safe are EPD (Enzyme Potentiated Desensitisation), LDA (low dose allergen therapy) and “neutalization” techniques used in UK (EPD and neutralization) and in US (LDA) in terms of creating tolerance to cancer cells?
    Thank you

  • Nissa

    While interesting, this is all theoretical based on a lot of research and no practical clinical application

  • Dennis Knöper

    my sister had a peanut allergy which she doesnt have anymore but now she react to casein with inflammation ( not allergy) . what does this tell you about her health ? did she shift from th1 dominant to th2 domiant ? she was living in a moldy house also

    1. Fred Lander

      For Dan if we combine UCII and egg shell will that result in going over the recommended dose for the UCII? The dosage is very strict as doubling the dose will inactivate the effect. I am not sure how much more they know of this. So can we add the egg shells and the UCII to the list of things that will slow down cartilage degradation, like saposhnikovia divaricata and morus alba? My personal experience has been that about 5 hours after eating a prohibited food, like two slices of pizza, I will get a severe pain in my knee where it is bone on bone, and the pain will be a throbbing pain. The throbbing is very specific and localized to the exact spot of bone on bone. My theory is that the throbbing part is the immune system actually attacking the cartilage in the joint. If there was no cartilage whatsoever then the joint would lock up. ( a point made by John Bergman at Youtube ).

  • Mary

    For SLE/Lupus, you recommend just ingesting animal based foods and excluding plant based foods, except leafy greens or sauerkraut. I’ve not heard of a ketogenic diet being used for Lupus. What is the science behind that?

    1. Joseph M. Cohen
  • Kyle

    What are your thoughts on this post by Jaminet on neu5gc. It appears to be sialic acid and he is saying it contributes to hashimotos. http://perfecthealthdiet.com/2015/02/neu5gc-autoimmunity-hashimotos-hypothyroidism/

  • Zazie

    Hey I have a question regarding black cumin oil. I started taking it because I have extremely sensitive stomach among others and it really helps, however I feel like it messes up my hormones.(of course I am not 100 percent) sure it is the BC oil My breasts are very swollen and painful and got new pimples (i just got rid of my acne- so extremely frustrating). I think it is because of the prolactin in BC oil. I also came across an article that said BC oil caused hormonal imbalances in diabetic women taking it for blood sugar regulation. (looking for the article now but cannot find it again) And had anti-fertility effects in rats. Do you know more about the effects of BC oil on the female reproductive system ?
    Can it be that the hormonal imbalance is temporary and that the anti-inflammatory and immune-regulating properties of BC oil will eventually balance hormones ? I don’t mind the bigger breasts but I don’t want to become infertile or increase my acne.

    1. Zazie
    2. Dan

      http://www.tandfonline.com/action/doSearch?AllField=Oral+Tolerance&ajaxpagination=standard&startPage=35

      curious amount of research 19+ thousand articles/papers on oral tolerance, sound like no money in treating people with it to me ? what do you think ?

  • Dan

    My Complements on this site, it has been difficult to explain how all this fits together I will post and add from my years of research

    Egg’s are quiet simply the best form of living collagen type 1, 3,4,5,10 ! mostly types 1 and 5, you can load up ! I mix 1-2 in blender with 1-2 bannannas and ice it quite simply is the best way I have found to swich off the attacks, my neuropathy and raynaunds has healed, my arthritis is totally controlled I still have seiver pain in neck and back but both areas need surgery so bone on bone at my age simply wont heal, for the rest of you it takes 300-500 days for your body to heal collegenetic matierals, and it would not even make sense how you body does it, it is 3d molecular replication from copying from the gut then destroying the collage to get the protiens to reconstruct new collagen – this is just a small part so eat your protien’s, espically collagen 1

    1. Fred

      Checked a wiki site for insulin index and eggs have the lowest. Makes one think more of eggs ( that is whole eggs ) during two million years of evolution. Being hungry in the spring you come across a birds nest and figure what a bonanza! Why not eat them whole? You are starving so plop in the whole thing. Do this for millions or hundreds of thousands of years. Could this be a thought experiment to explain the evolution of oral tolerance and why eggs are so close to the perfect food? Now what about chicken cartilage and UCII? Paleolithic man could not undenature things in a laboratory, but could suck out the cartilage in the bones! And at some point boil them in water to extract all nutrients. What else works via the oral tolerance beside the egg shell and UCII?

    2. Kelly

      Raw eggs completely block biotin, not a good thing. Also, try some hyaluronic acid, especially the liquid form, and save yourself from surgery.

  • Gregory

    But what would even 10000x more interesting is to hear about super! Have you done any research in this regard? http://en.wikipedia.org/wiki/SuPAR

  • Gregory

    Would be very interseted in reading a post on il-2! Thank you!

    1. Joseph M. Cohen

      IL-2 is Th1 dominance

  • Phil

    Something else I keep reading that helps tolerance and allergies is NAET. I’ve not looked into it, but it’s mentioned in comments sections online so often I can’t help but wonder if there’s something to it..

  • Phil

    I was reading a book today that said the opposite of what you say here…that a meat based diet is likely to make one more ill when suffering autoimmune problems. All those proteins the body has to process and deal with! I have no idea if it’s right or not but thought I would mention it!

    I’ve also seen anecdotal reports that many kids who go on GAPS/SCD diets get worse due to all the meat…too much ammonia by-products they can’t get rid of.

    1. Joseph M. Cohen

      “All those proteins the body has to process and deal with!” Please be more specific as to what you mean and why this is harmful.

      I recommend 20% or less of the diet be protein and within a framework of caloric restriction (unless you’re super thin). Unless your liver is killed, 20% doesn’t create too much ammonia.

      Please back up your ideas with scientific sources or credible biology.

      1. Dan

        proteins the body has to deal with ? you are nothing but collage with minerals, it is all protein, these immune conditions attacking collage type 1 are deadly, they are not forgiving, Mayo clinic ran ever possible scenaerio end result was 100% loss of subjects, building up you collagen and keeping it as healthy as possibe and immune attack as low as possible extends life the egg shell membrane containing 5 forms especially type 1, is good for oral tolerance as the collagen is in it living raw form

        http://en.wikipedia.org/wiki/Collagen

        Collagen occurs in many places throughout the body.[citation needed] Over 90% of the collagen in the body, however, is type I.[40]

        So far, 28 types of collagen have been identified and described. The five most common types are:

        Collagen I: skin, tendon, vascular ligature, organs, bone (main component of the organic part of bone)
        Collagen II: cartilage (main component of cartilage)
        Collagen III: reticulate (main component of reticular fibers), commonly found alongside type I.
        Collagen IV: forms basal lamina, the epithelium-secreted layer of the basement membrane.
        Collagen V: cell surfaces, hair and placenta
        Collagen-related diseases most commonly arise from genetic defects or nutritional deficiencies that affect the biosynthesis, assembly, postranslational modification, secretion, or other processes involved in normal collagen production.

        Genetic Defects of Collagen Genes
        Type Notes Gene(s) Disorders
        I This is the most abundant collagen of the human body. It is present in scar tissue, the end product when tissue heals by repair. It is found in tendons, skin, artery walls, cornea, the endomysium surrounding muscle fibers, fibrocartilage, and the organic part of bones and teeth. COL1A1, COL1A2 Osteogenesis imperfecta, Ehlers–Danlos syndrome, Infantile cortical hyperostosis aka Caffey’s disease
        II Hyaline cartilage, makes up 50% of all cartilage protein. Vitreous humour of the eye. COL2A1 Collagenopathy, types II and XI
        III This is the collagen of granulation tissue, and is produced quickly by young fibroblasts before the tougher type I collagen is synthesized. Reticular fiber. Also found in artery walls, skin, intestines and the uterus COL3A1 Ehlers–Danlos syndrome, Dupuytren’s contracture
        IV Basal lamina; eye lens. Also serves as part of the filtration system in capillaries and the glomeruli of nephron in the kidney. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6 Alport syndrome, Goodpasture’s syndrome
        V Most interstitial tissue, assoc. with type I, associated with placenta COL5A1, COL5A2, COL5A3 Ehlers–Danlos syndrome (Classical)
        VI Most interstitial tissue, assoc. with type I COL6A1, COL6A2, COL6A3, COL6A5 Ulrich myopathy, Bethlem myopathy, Atopic dermatitis[41]
        VII Forms anchoring fibrils in dermoepidermal junctions COL7A1 Epidermolysis bullosa dystrophica
        VIII Some endothelial cells COL8A1, COL8A2 Posterior polymorphous corneal dystrophy 2
        IX FACIT collagen, cartilage, assoc. with type II and XI fibrils COL9A1, COL9A2, COL9A3 EDM2 and EDM3
        X Hypertrophic and mineralizing cartilage COL10A1 Schmid metaphyseal dysplasia
        XI Cartilage COL11A1, COL11A2 Collagenopathy, types II and XI
        XII FACIT collagen, interacts with type I containing fibrils, decorin and glycosaminoglycans COL12A1 –
        XIII Transmembrane collagen, interacts with integrin a1b1, fibronectin and components of basement membranes like nidogen and perlecan. COL13A1 –
        XIV FACIT collagen, also known as undulin COL14A1 –
        XV – COL15A1 –
        XVI – COL16A1 –
        XVII Transmembrane collagen, also known as BP180, a 180 kDa protein COL17A1 Bullous pemphigoid and certain forms of junctional epidermolysis bullosa
        XVIII Source of endostatin COL18A1 –
        XIX FACIT collagen COL19A1 –
        XX – COL20A1 –
        XXI FACIT collagen COL21A1 –
        XXII – COL22A1 –
        XXIII MACIT collagen COL23A1 –
        XXIV – COL24A1 –
        XXV – COL25A1 –
        XXVI – EMID2 –
        XXVII – COL27A1 –
        XXVIII – COL28A1 –
        In addition to the above-mentioned disorders, excessive deposition of collagen occurs in scleroderma.

        1. Joseph M. Cohen

          I don’t see how your comment is relevant to what I was saying.

          Phil said that eating protein causes harm.

          My question was how does 20% or less protein cause harm in someone with a functioning liver? What’s the mechanism?

          I’ve spoken about mTOR, but phil seems to describe other mechanisms of harm.

    2. Dan

      I am on Oral Tolerance protocol now,(I am using whole raw eggs shell and all) 2x daily blended with bannanna til shells are mostly dissolved, to get the collagen type 1, 4,5,+10 type 1 being 90% of our collagens thus the target tolerance collagen, started in May 30 of 2014, remarkable results, I was nearly flat on my back in bed 90% of the time to where raynaunds, neuropathy, arthritis and colon problems have all demenished, I have regained 25 pounds, I have alerted my doctor and went over broken neck area and crushed vertebra area’s, he is impressed with my progress however he was forthcoming about the bone on bone neck and back as surgery would be the only way for any pain relief in these area’s, which is obviously mehanical failure at this point and quite simply nothing even their to heal,

      on the Topic of meat’s Meats should render the same collagen’s that I am currently getting out of the egg’s however 2 things are a problem in meats, 1st and most important is you must ingest the collagen in it LIVING molecule form, and 2nd you cannot change its structure by cooking or even heating, thus I would see my self with BBQ sauce at the Co-oP with a bib around my neck a chain saw in one hand and giant fork in the other for getting those rib’s just after the cow’s slaughter, thus the egg’s have living collagen in the egg’s shell membrane and the rest is just full of nutrients – ill keep you posted so far im getting better by the day

    3. Dan

      well their are 2 points here, 1st point is going vegan, to reduce inflamation and swelling however the long and short of it a vegan diet starves you of key important protien’s you need and your body will cannibilize itself to get vitamin b’s from your muscle so as you get thinner I suppose you would reduce infflamation, however a protein diet builds lean muscle mass (you can even eat the fats, bone and marrow) these are like taking a super nutrient rich nutrient dose ! then obviously the carbs’s this takes in everything else that would end in a TOSE – from glucose, to lactose, fruitose etc/// no obviously these would contributer to inflamation and swelling along with weight gain, if you are AI comprimised and have had a good physical with normal labs ask your doctor on getting on a strict protein diet, myselfe personally I eat 2-4 raw egg’s a day 2 breakfast and 2 at bedtime and just wash the shells, the egg shells are the perfect form of 27 minerals for calcium carbonate uptake, the egg shell membrane inside has collagen 1,3,4,5,10 (1,5 predominatly) which is the living form of these molecules, 90% of all your collagen is type 1, this acts as a switch to turn off any immune attack to these collagens and can be felt in as soon as 4 hours, im on week 24 and we will know soon if I have any regeneration / healing in my back, neck, and other joints from it, and I too eat the whole bird soak the bones for a day or two a knaw down
      this is a excellent site, most of this research I also have compiled similar data showing the same things, even clinical trials and it isnt all that new, HG Wells over 100 years conducted studies, but we loose as much as we gain in knowledge the internet will put these doctors in line or out of business !

    4. Dan

      eliminating meat’s (protein’s from your diet specifically animial protien puts you vegan, how many old vegan’s do you see ?

  • Daniel

    So, if I have psoriasis I have to eat skin?

    1. Joseph M. Cohen

      I don’t know. What protein is attacked in psoriasis? Worth a shot.

      It seems like psoriasis is more about systemic inflammation combined with certain genetics in how your skin cells behave, in which the inflammation is attracted to the skin.

      Specifically, increased levels of cathelicidin LL-37, which binds to self-DNA released from dying in skin cells. Causes inflammation by activating dendritic cells. .
      http://www.ncbi.nlm.nih.gov/pubmed/22509827

      The antibodies elevated in psoriasis don’t seem to be skin specific:
      http://onlinelibrary.wiley.com/doi/10.1002/jcla.20365/abstract

      If you have research about specific skin proteins being attack then post it.

      1. Daniel

        Oh well I simply guessed that if I have to eat brain for ms I have to eat skin for psoriasis… Since it is an inflammation skin condition… It sounded too simple which is why I asked…

      2. Dan

        it’s collagen type 1, eat egg’s whole raw egg’s they have it, and stop it, mix em up with fav bananna’s and ice tast good, its all in the eggs shell membrane, look it up, Im eating 4-6 a day now but start out slowly

        1. Joseph M. Cohen

          I have an egg shell membrane supplment that’s been sitting around for 6 months waiting to be tried. Maybe I’ll give it a go.

    2. Dan

      90% chance it is type 1 collagen in skin, over 1000 triggers have been identifyed and over 100 named immune conditions named, all attacks on type 1 collagen, it does not matter the trigger or the type, you must get the attack against your collagen 1 stopped or slowed down, read above the whole egg and bannana shake is working and taste good !the egg shells membrane (the part we throw away is what has the collagen) here is a list of them all (28 total) http://en.wikipedia.org/wiki/Collagen READ CLOSELY and pay attention collagen type 1 and all other collagens that support type 1 as basement and foundation collagens, type 1 should take care of 90% of conditions

      1. Joseph M. Cohen

        You’ve got studies that show that in Psoriasis Type 1 collagen is attacked?

        ” and over 100 named immune conditions named”

        Studies?

        1. Dan

          http://en.wikipedia.org/wiki/Collagen
          (One thousand mutations have been identified in twelve out of more than twenty types of collagen. These mutations can lead to various diseases at the tissue level)
          Once you develop a autoimmune condition, AI attack, it really matters not what the doctor names it, they classify by symptoms or exposure, read the link CLOSELY and completely, the named conditions are only examples in the link, the 1,000+ and still counting really matters not as your condition probably started 10-20 years earlier, its only now when you enter stage 3 or 4 that pain and suffering from attack’s being elevated to nerve’s bone, joints and skin does it become more than obvious, Do google search on Oral tolerance, collagen conditions, and pay really close attention again to that type 1, Eggs have it in the egg shell membrane, but you cannot cook it, that destroys the molecule your after and just leaves you with cooked protien’s, raw works, start with 1 a day and move up to 2 a day in a week, then move up to 3, then 4, two at breakfast and two at bedtime for a few months and you should start feeling better, if you are having a sevier attack you could feel better in as soon as 4 hours, (it will act as a drug turning off the T cell and complement system attack, my first one broke me into a sweat like breaking a feaver, the next day I knew I was on the right track, as pain was easing off, now 8 months later just typical OA type pain, no more of the intense abcess feeling of pain you just cannot get over, (thats attack going on ) blasting your last remaining collagen to bits, (fwiw we dont make more collagen after about 40-50, what you have is what you got, real slow to heal , 300-500 days, to replace it, so the quote “sooner rather than later” makes sense or the obvious outcome is well /// No more pain ever

  • Oretz

    You wrote earlier that you have been eating ice cream for almost a week – I guess you were trying to induce tolerance – were you successful?

    I know you are sensitive to dairy and eggs and herring – did you manage to to become tolerant of these proteins?

    1. Joseph M. Cohen

      Dairy has lectins in there, too. And it wasn’t to create tolerance.

      I have a feeling herring has some shit in there besides proteins that was giving me issues.

      Eggs- I’m going to experiment with building tolerance to it…

      1. Dan

        they work, eat the whole egg, the main collagen you want is in the egg shell membrane, -the part that gets tossed away!, I am on them month 7 with alarming results

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