Phosphatidylserine is found in high amounts in the brain. It’s a popular dietary supplement used to improve mental focus, memory, and mood. Does it really work? Read on to learn more about the health benefits of phosphatidylserine, potential side effects, and optimal dosage.
Phosphatidylserine is a phospholipid (a fat molecule attached to a phosphate) and is a major component of all cell membranes. It has particular importance in brain function; people use it as a supplement to improve cognitive function and memory, relieve stress, and more .
A supplement containing 400 mg phosphatidylserine (PS) increased the speed of mathematical calculations and decreased errors in a clinical trial of 18 young people .
In another clinical trial of 72 people, 300 mg/day of phosphatidylserine with phosphatidic acid improved memory and mood .
Alzheimer’s disease is associated with the accumulation of amyloid beta in the brain. Studies have shown that phosphatidylserine (PS) prevents this accumulation, which could help prevent or slow the progression of the disease .
In a clinical trial of 51 people with Alzheimer’s, PS reduced the symptoms and enhanced cognition, with greater results in those with milder impairment .
300 mg/day also improved dementia symptoms and behavior in a clinical trial of 42 senile patients .
Larger, well-designed clinical trials are needed
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