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PPAR Delta: Burn Fat & Become an Endurance Athlete

Written by Joe Cohen, BS | Last updated:

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PPAR delta is important for heart function, energy production, endurance capacity, reducing inflammation and reducing obesity.

PPAR Delta Simple

PPARδ is a nuclear hormone receptor that governs a variety of biological processes and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer.

PPARδ may function as an integrator of sorts.

PPARδ helps prevent heart disease [1].

PPARδ is important for hair growth [2].

At higher levels, PPAR-δ increases fat burning in muscle and fat cells and increases energy expenditure. At lower levels, it helps create fat cells [3, 4].

PPARδ is found to be elevated in colorectal cancer cells.

Studies into the role of PPAR-δ in cancer have produced contradictory results and there is no scientific consensus on whether it promotes or prevents cancer formation [5].

PPARδ is involved with the absorption of fat and cholesterol (lipid uptake, such as fatty acid binding protein and fatty acid translocase). Also, it helps the growth of intestinal mucosa in response to fat [3].

PPARδ decreases inflammatory responses of macrophages and is linked to a significant rise in HDL cholesterol. PPAR activation in the liver decreases liver glucose output, thereby contributing to improved glucose tolerance and insulin sensitivity [6].

In a meta-analysis, PPAR delta was associated with height [7].

PPAR Delta Advanced

PPAR delta decreases Cannabinoid receptor expression [8].

PPAR delta decreases inflammatory cytokines such as TNF and macrophage-related inflammation (R). PPARδ helps prevent TNFα-induced apoptosis in skin cells [3].

PPAR delta is a potent inhibitor of activation of PPAR alpha and PPAR gamma [9].

PPAR delta inhibits the Th1 and Th17 immune systems [10] and combats autoimmunity [11], and causes weight loss.

Treatment of obese animals by PPARδ activators results in normalization of metabolism and a reduction of body bat. PPARδ also can increase fat cells when on a high-fat diet by stimulating preadipocyte proliferation and by controlling the induction of PPAR gamma [3].

The nuclear receptor increases the fatty acid burning capacities of muscle and fat tissue by controlling the expression of genes involved in fatty acid uptake, β-oxidation, and energy uncoupling [3].

PPAR delta increases the production of PGC-1a and TGF-beta [12].

PPAR delta potentiates PPAR gamma fat cell production [13].

PPARδ increases FGF-21 [14].

Well described target genes of PPARδ include PDK4, ANGPTL4, PLIN2, and CD36.

PPAR Delta SNPs: rs2016520 T294C

Check out Selfdecode to see if you have these genes.

  1. RS1053049 (PPARD) CC
  2. RS1883322 (PPARD) CC
  3. RS2016520 (PPARD) CT
  4. RS2076167 (PPARD) CC
  5. RS2076169 (PPARD) AA
  6. RS2267668 (PPARD) AG
  7. RS6922548 (PPARD) AG

How to Increase PPAR delta

If you want to interpret your genes and see how they affect your PPAR Delta, you can upload them into SelfDecode.

SelfDecode is a sister company of SelfHacked. The proceeds from your purchase of this product are reinvested into our research and development, in order to serve you better. Thank you for your support.

About the Author

Joe Cohen, BS

Joe Cohen won the genetic lottery of bad genes. As a kid, he suffered from inflammation, brain fog, fatigue, digestive problems, anxiety, depression, and other issues that were poorly understood in both conventional and alternative medicine. Frustrated by the lack of good information and tools, Joe decided to embark on a journey of self-experimentation and self-learning to improve his health--something that has since become known as “biohacking”. With thousands of experiments and pubmed articles under his belt, Joe founded SelfHacked, the resource that was missing when he needed it. SelfHacked now gets millions of monthly readers. Joe is a thriving entrepreneur, author and speaker. He is the CEO of SelfHacked, SelfDecode and LabTestAnalyzer. His mission is to help people gain access to the most up-to-date, unbiased, and science-based ways to optimize their health.
Joe has been studying health sciences for 17 years and has read over 30,000 PubMed articles. He's given consultations to over 1000 people who have sought his health advice. After completing the pre-med requirements at university, he founded SelfHacked because he wanted to make a big impact in improving global health. He's written hundreds of science posts, multiple books on improving health, and speaks at various health conferences. He's keen on building a brain-trust of top scientists who will improve the level of accuracy of health content on the web. He's also founded SelfDecode and LabTestAnalyzer, popular genetic and lab software tools to improve health.

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