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Pterostilbene is a powerful antioxidant that can help with everyday health by improving brain, heart, and immune system function. Since it has no known toxicity level, this is a good supplement to use. Read more below to learn more about its advantages.

What is Pterostilbene?

Pterostilbene is an antioxidant found in almonds, grape leaves and vines, and especially blueberries. It is chemically similar to Resveratrol, a chemical found in wine. The supplement is linked to improved cognition, reduced cholesterol and glucose, and increased insulin sensitivity (R).

It is currently being studied as the “better,” more effective version of resveratrol because it is more easily absorbed into the body (R).

Pterostilbene Snapshot


  • Improves cognition and prevents brain cell death
  • Good anti-inflammatory
  • Reduces blood sugar
  • Helps fight against cancer
  • Lowers blood pressure
  • Help lose weight


  • High doses can increase cholesterol

Health Benefits of Pterostilbene:

1) Pterostilbene Improves Brain Function 

Working memory and dopamine release is related to pterostilbene levels in the hippocampus (memory center) (R).

Pterostilbene reduces the effect of glutamate-caused injuries in brain cells (R).

It also reduced brain cell death rate and increased cell viability in cells related to the development of Alzheimer’s disease (R).

When given supplements in their diet, rats had improved cognition in a 12-13 week time span (R).

In smaller doses, the antioxidant helps reduce anxiety and improve mood in mice subjected to cognitive tests (R).

2) Pterostilbene Reduces Blood Sugar

In hamsters with high cholesterol, daily dosages lowered blood glucose (R).

In normal and diabetic rats, blood sugar levels decreased and insulin levels increased (R).

Pterostilbene increased the activity of a blood sugar regulator in the liver tissue in diabetic mice (R).

3) Pterostilbene Has Anti-Cancer Effects

Pterostilbene increased cell death and decreased cell reproduction (R).

It prevents the development of blood vessels, an important role in tumor growth and cancer cell movement (R).

The antioxidant decreased cancer cell metastasis and increased the rate of cancer cell death. In human lung cancer, cancer cell migration also decreased (R).

Doses of this supplement lowered the rate of melanoma and pancreatic cancer cell growth by decreasing glucocorticoid production (R).

When fed this supplement, the level of pinostilbene increased in mice, which may play a significant role in causing cell death in colon cancer cells (R).

4) Pterostilbene Benefits the Muscular and Heart System

Pterostilbene helps restriction of blood reperfusion injuries by activating a certain pathway involved in injury response (R).

Blood pressure was lowered in adults with high cholesterol, but LDL or “bad cholesterol” increased (R).

When given a pterostilbene-caffeine supplement, resistance-trainer bodybuilders’ quadriceps muscles increased in thickness (R).

5) Pterostilbene Helps You Lose Weight

Middle-aged patients, who were not on cholesterol medication, lost weight after taking daily supplements. However, if the supplements were taken in addition with GSE, none of the weight loss effects were seen (R).

6) Pterostilbene Has Anti-Inflammatory Effects

Human corneal epithelial cells had less inflammation and less stress when exposed to pterostilbene (R).

It also reduced inflammation in human eye cells in a high sugar environment (R).

Additionally, endothelial cells have reduced inflammation (R).

7) Pterostilbene May Lengthen Your Lifespan

Oxidative stress in cells can cause aging and other disorders related to old age. Low doses of the antioxidant can lower cellular and cognitive stress (R, R).


  • Reactivates estrogen receptor-alpha receptor production in breast cancer cells (R).
  • Suppresses self-renewal ability in lung cancer cells (R).
  • Decreases MUC1, NF-κB, CD133, β-catenin, and Sox2 production (R).
  • Activates the SIRT1-FOXO1/p53 pathway  (R).
  • Inactivates the NF-κB pathway regulated by TLR5 down-regulation (R).
  • Suppresses inflammatory response via NF-κB inactivity in LPS or TNF-α-induced VSMCs by decreasing TLR5 production  (R).
  • Increases nuclear Nrf2 and HO-1 and NQO1 levels, increases production of anti-oxidants glutathione and superoxide dismutase (R).
  • Reduced production of reactive oxygen species (R).
  • Decreased tumor cell adhesion, migration and intracellular GSH levels (R).
  • Increased the production of endoplasmic reticulum stress signaling-related molecules (GRP78, ATF6, p-PERK, p-eIF2α and CHOP) (R).
  • Promoted the translocation of cytochrome c from mitochondria to cytosol and the activation of Caspase 9 and Caspase 12 (R).
  • Stimulates and enhances sirt1 activity and production (R).
  • Increases TSP-1 protein production levels (R).
  • Decreases levels of oxidative damage biomarkers, malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), aconitase-2 and 8-hydroxydeoxyguanosine (8-OHdG) (R).
  • Increases activity of superoxide dismutase 1 (SOD1) and peroxiredoxin-4 (PRDX4) during stress  (R).
  • Promotes phosphorylation of Akt and affects different PI3K/Akt pathway (R).
  • Suppress human retinal endothelial cells, decrease  TNF-α and IL-1β, inhibit NF-κB protein expression, reduce ROS production, and increase SOD activity (R).
  • Decreases glucocorticoid receptor- and nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-dependent levels (R).
  • Decreased the production levels of TRAP, cathepsin K (CTSK), matrix metalloproteinase 9 (MMP9) and proteins that turn genes on c-Fos, and nuclear factor of activated T cells cytoplasmic 1 (NFATc1) (R).

Sources of Pterostilbene

  • Pterocarpus marsupium (Indian Kino tree) (R)
  • Blueberry and deerberry (R)
  • Grapes (R)
  • Peanuts (R)
  • Dracaena plants (R)

Side Effects

High dosages of pterostilbene can cause LDL cholesterol to increase. There are no other known side effects (R).

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