Evidence Based This post has 53 references

Can Skullcap Help with Coronavirus (COVID-19)?

Written by Carlos Tello, PhD (Molecular Biology) | Last updated:
Puya Yazdi
Medically reviewed by
Puya Yazdi, MD | Written by Carlos Tello, PhD (Molecular Biology) | Last updated:

SelfHacked has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. We believe that the most accurate information is found directly in the scientific source.

We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic.

Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists.

All of our content is written by scientists and people with a strong science background.

Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again.

Our goal is to not have a single piece of inaccurate information on this website. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at [email protected]

Note that each number in parentheses [1, 2, 3, etc.] is a clickable link to peer-reviewed scientific studies. A plus sign next to the number “[1+, 2+, etc...]” means that the information is found within the full scientific study rather than the abstract.

This article is for informational purposes only. The current coronavirus outbreak is an ongoing event and certain details may change as new information comes to light. No effective or FDA-approved products are currently available for the treatment of the new coronavirus (also known as SARS-CoV-2 or 2019-nCoV), although research is still ongoing.

Baicalein is a flavone, a type of polyphenolic flavonoid, that is extracted from the roots of Scutellaria baicalensis and Scutellaria lateriflora.

Baicalin is a flavone glycoside, the glucuronide of baicalein, which is obtained through the binding of glucuronic acid to baicalein. It is primarily used in Asian countries as an herbal supplement.

Lung Function

Pure baicalin improved lung function in rats suffering from allergic diseases [1].

When given to asthmatic rats as a pretreatment, baicalin stimulated a healthy remodeling of the airway. Similarly, baicalein reduced airway inflammation, injury, and remodeling in asthmatic mice [2, 3, 4].

In mice with pulmonary hypertension (a progressive condition in which excess of pressure in the lungs leads to their failure), baicalin prevented the development of the condition by reducing pressure and inflammation [5].

Baicalein reduced lung inflammation by inhibiting Th17 cells in the lungs of mice exposed to mineral dust [6].

In rats and mice exposed to cigarette smoke, baicalin protected lung function and reduced inflammatory markers [7, 8].

In mice with lung injury caused by a chemotherapeutic drug (bleomycin), a traditional Chinese medicine with skullcap reduced tissue scarring and inflammation [9].

Similarly, skullcap extract and its active compound wogonin reduced lung damage in mice with acute lung injury (a condition that may progress into ARDS) by reducing inflammation [10, 11].

However, Chinese medicines with skullcap have been reported to cause ARDS in some people [12].

Skullcap extracts may improve lung function by reducing inflammation, but this has only been studied in animals so far.

Respiratory Infections

Traditionally, Chinese skullcap is used to fight off infections, especially respiratory ones. A meta-analysis of 8 clinical trials concluded that the Chinese medicine Shunag Huang Liang may relieve fever, cough, sore throat, and reduce the disease course in acute upper respiratory tract infections. However, the authors warned about the poor quality of the included studies [13].

Skullcap extract, herbal medicines containing it (KIOM-C and San Wu Huangqin), and its active compound baicalein improved survival and reduced viral load, lung injury, and inflammation in mice infected with the 2009 swine pandemic flu (H1N1). In one of them, baicalein enhanced the effects of the antiviral drug ribavirin [14, 15, 16, 17, 18, 19, 20].

In one cell study, skullcap was more effective in reducing the replication of the swine flu virus than a drug used to treat and prevent it (oseltamivir phosphate) [21].

In mice with pneumonia caused by the common flu, skullcap root extract reduced inflammation by blocking the production of pro-inflammatory cytokines while stimulating those with an anti-inflammatory effect [22].

In mice infected with the respiratory syncytial virus (RSV), baicalin reduced viral loads, inflammation, and lung injury [23].

In chicken with infectious laryngotracheitis virus, a Chinese formula with skullcap (Yinhuangerchen mixture) reduced viral loads, boosted the immune system, and reduced tissue damage [24].

In test tubes, skullcap extract, herbal medicines containing its root, and active components such as baicalein, baicalin, and wogonin inhibited the following respiratory viruses:

  • SARS-CoV-1 [25]
  • Flu (H1N1, H3N2, influenza B) [26, 27, 28, 21, 29]
  • Human adenovirus III [30]
  • Respiratory syncytial virus (RSV) [31]
  • Newcastle disease virus (a chicken coronavirus) [32]
  • Sendai virus (a parainfluenza virus from mice) [33]
Animal and cell studies have found that skullcap and its extracts reduced viral load and improved survival rates.

Other Viral Infections

In a clinical trial on over 700 children with severe foot-and-mouth disease, treatment with Chinese skullcap reduced viral loads and fever, relieved mouth wounds and rashes, and improved neurological symptoms [34].

Skullcap reduced hepatitis C levels and blocked the virus from replicating in infected mice. Wogonin, its active component, reduced replication of the hepatitis B virus in ducks and improved their liver function [35, 36].

Skullcap extract also reduced inflammation, death rate, and viral replication in mice with heart muscle inflammation caused by coxsackievirus B3. Similarly, its flavonoid oroxylin A reduced viral loads and pancreatic inflammation due to this virus [37, 38].

When exposed to HIV, skullcap and its active component baicalin were active against its replication and blocked the activity of enzymes the virus needs to spread [39, 40, 41, 42, 43].

Skullcap, herbal formulations containing it, and its active components also inhibited the following viruses in test tubes:

  • Enterovirus 71 [44, 45]
  • Hepatitis B [46]
  • Hepatitis C [47]
  • Duck hepatitis A virus [48]
  • Dengue [49, 50]
  • Coxsackievirus B3 [51]
  • Epstein-Barr virus [52]
  • Tick-borne encephalitis virus [53]
Skullcap contains active components with antiviral activity, and skullcap supplements reduced viral load in children with foot-and-mouth disease.

About the Author

Carlos Tello

Carlos Tello

PhD (Molecular Biology)
Carlos received his PhD and MS from the Universidad de Sevilla.
Carlos spent 9 years in the laboratory investigating mineral transport in plants. He then started working as a freelancer, mainly in science writing, editing, and consulting. Carlos is passionate about learning the mechanisms behind biological processes and communicating science to both academic and non-academic audiences. He strongly believes that scientific literacy is crucial to maintain a healthy lifestyle and avoid falling for scams.

Click here to subscribe


1 Star2 Stars3 Stars4 Stars5 Stars
(1 votes, average: 5.00 out of 5)

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.