CYP19A1 Enzyme (Aromatase): Gene Variants and Natural Inhibitors

CYP19A1, also known as aromatase, is an important enzyme that produces estrogen. By regulating estrogen production, CYP19A1 affects a variety of processes in the body, including fat production and distribution, bone density, female fertility and brain function. Estrogen deficiency is associated with diseases such as osteoporosis, atherosclerosis, and Alzheimer’s disease. CYP19A1 variants are further associated with migraines and the growth of estrogen-sensitive cancers. In this post, you will find information about aromatase function, gene variants, and natural substances that decrease its activity.

Read More

CYP17A1 Enzyme: Function, Gene Variants, and Ways to Decrease It

CYP17A1 is an important enzyme for the production of steroid hormones, including testosterone and estrogen. CYP17A1 gene variants are associated with elevated blood pressure, cardiovascular disease, Alzheimer’s and cancer risk. Read on to find out more about CYP17A1 function, genetics and factors that decrease enzyme activity.

Read More

CYP11A1 Enzyme: Function, Gene Variants and Ways to Increase or Decrease It

CYP11A1 is essential for the production of steroid hormones (estrogen, testosterone, aldosterone, cortisol). It converts cholesterol into pregnenolone, from which all other steroid hormones are made. CYP11A1 also acts as an anti-inflammatory but pro-allergic agent. Read on to learn more about CYP11A1 function, gene variants and factors that increase or decrease it.

Read More

CYP2D6 Enzyme: How it Affects Your Brain

CYP2D6 is one of the most important detoxication enzymes. CYP2D6 is responsible for the clearance of 20% of clinical drugs, including opioids (codeine, tramadol), antitumor drugs (tamoxifen), antidepressants (fluoxetine), and antipsychotics (haloperidol). In addition, CYP2D6 also metabolizes dopamine and serotonin, and the activity of this enzyme is often associated with human personality, behavior, and disease susceptibility. Read on to find out more about CYP2D6 function, gene variants, and supplements that increase or decrease CYP2D6 activity.

Read More

CYP2C19 Enzyme: Drugs, Gene Variants, and Inhibitors

CYP2C19 is an important detoxication enzyme responsible for clearing approximately 10% of commonly used clinical drugs, including antidepressants (citalopram), proton pump inhibitors (omeprazole), and antiplatelet drugs (clopidogrel/Plavix). Elevated CYP2C19 activity is associated with depression. Read on to find our more about CYP2C19 function, gene variants, and supplements that decrease CYP2C19 activity.

Read More

CYP2C9 Enzyme: Drugs, Gene Variants, and Inhibitors

CYP2C9 is an important drug-metabolizing enzyme. It is responsible for the clearance of up to 15-20% of clinical drugs, including antidiabetics (tolbutamide), antiepileptics (phenytoin, valproate), antihypertensive drugs (losartan), and anticoagulants (warfarin). CYP2C9 gene variants greatly affect the way we react to these drugs. Learn more about CYP2C9 function, genetics, and factors that increase or decrease CYP2C9 activity.

Read More

CYP1B1 Enzyme: Function, Genetics, and Ways to Increase or Decrease It

CYP1B1 is an important detoxication enzyme that helps combat oxidative stress. This enzyme is also important for eye development. Mutations in the CYP1B1 gene are associated with congenital glaucoma. On the other hand, lower activity of this enzyme may be protective against obesity and cancer, by regulating the levels of steroid hormones in our bodies. Learn more about this enzyme and factors that can increase or decrease its activity.

Read More

CYP1A2 Enzyme: Where Caffeine Meets Genetics

CYP1A2 is an important enzyme that helps break down toxins in our bodies. It is the key enzyme responsible for metabolizing caffeine, and therefore variations in the CYP1A2 gene have a big impact on how coffee will affect our bodies. CYP1A2 gene variants have also been associated with diabetes, bone density, and cancer. Read on to find out more about this enzyme, and the natural substances that can increase or decrease it.

Read More