CYP19A1, also known as aromatase, is an important enzyme that produces estrogen. By regulating estrogen production, CYP19A1 affects a variety of processes in the body, including fat production and distribution, bone density, female fertility and brain function. Estrogen deficiency is associated with diseases such as osteoporosis, atherosclerosis, and Alzheimer’s disease. CYP19A1 variants are further associated with migraines and the growth of estrogen-sensitive cancers. In this post, you will find information about aromatase function, gene variants, and natural substances that decrease its activity.
CYP17A1 is an important enzyme for the production of steroid hormones, including testosterone and estrogen. CYP17A1 gene variants are associated with elevated blood pressure, cardiovascular disease, Alzheimer’s and cancer risk. Read on to find out more about CYP17A1 function, genetics and factors that decrease enzyme activity.
CYP11A1 is essential for the production of steroid hormones (estrogen, testosterone, aldosterone, cortisol). It converts cholesterol into pregnenolone, from which all other steroid hormones are made. CYP11A1 also acts as an anti-inflammatory but pro-allergic agent. Read on to learn more about CYP11A1 function, gene variants and factors that increase or decrease it.
CYP3A5 shares many similarities with CYP3A4. This would mean it possibly participates in the clearance of >50% clinically used drugs. However, a striking feature of this enzyme is that many people actually don’t have it. Read on to find more about the gene variants of this enzyme, and how they affect drug metabolism and disease risk.
CYP3A4 is one of the most important CYP enzymes. It is responsible for the clearance of approximately 45% – 60% of currently prescribed drugs. Different supplements, food additives, and other substances can inhibit CYP3A4 activity and, as a result, interfere with drug metabolism. Find out more about CYP3A4 function, gene variants, and supplements that can increase or decrease CYP3A4 activity.
CYP2E1 is an important detoxication enzyme involved in the metabolism of alcohol. It also metabolizes paracetamol (acetaminophen). This enzyme clears toxins, but can also activate them. CYP2E1 activity was associated with alcohol-related pathologies and cancer. Read on to find out more about CYP2E1 function, genetics, and factors that increase or decrease enzyme function.
CYP2D6 is one of the most important detoxication enzymes. CYP2D6 is responsible for the clearance of 20% of clinical drugs, including opioids (codeine, tramadol), antitumor drugs (tamoxifen), antidepressants (fluoxetine), and antipsychotics (haloperidol). In addition, CYP2D6 also metabolizes dopamine and serotonin, and the activity of this enzyme is often associated with human personality, behavior, and disease susceptibility. Read on to find out more about CYP2D6 function, gene variants, and supplements that increase or decrease CYP2D6 activity.
CYP2C19 is an important detoxication enzyme responsible for clearing approximately 10% of commonly used clinical drugs, including antidepressants (citalopram), proton pump inhibitors (omeprazole), and antiplatelet drugs (clopidogrel/Plavix). Elevated CYP2C19 activity is associated with depression. Read on to find our more about CYP2C19 function, gene variants, and supplements that decrease CYP2C19 activity.
CYP2C9 is an important drug-metabolizing enzyme. It is responsible for the clearance of up to 15-20% of clinical drugs, including antidiabetics (tolbutamide), antiepileptics (phenytoin, valproate), antihypertensive drugs (losartan), and anticoagulants (warfarin). CYP2C9 gene variants greatly affect the way we react to these drugs. Learn more about CYP2C9 function, genetics, and factors that increase or decrease CYP2C9 activity.
CYP2C8 is one of the most important drug-metabolizing detoxication enzymes. It metabolizes over 60 clinical drugs including antidiabetics (rosiglitazone), anticancer drugs (paclitaxel, imatinib), and NSAIDs (diclofenac, ibuprofen). Find out how CYP2C8 gene variations may affect you in terms of drug metabolism, and which supplements/drugs interfere with CYP2C8 activity.
CYP2B6 is a detoxication enzyme that metabolizes drugs such as efavirenz, bupropion, cyclophosphamide, and thiotepa. The CYP2B6 gene is highly variable, which explains why these drugs have different effects in different people. Read on to find out more about this enzyme, its gene variants, and factors that increase or decrease its activity.
CYP2A6 is the detoxication enzyme responsible for eliminating nicotine. There is a link between CYP2A6 activity, smoking, and lung cancer risk. Read on to find more about this enzyme, how CYP2A6 genetic variants may affect you, and the factors that increase or decrease this enzyme’s activity.
CYP1B1 is an important detoxication enzyme that helps combat oxidative stress. This enzyme is also important for eye development. Mutations in the CYP1B1 gene are associated with congenital glaucoma. On the other hand, lower activity of this enzyme may be protective against obesity and cancer, by regulating the levels of steroid hormones in our bodies. Learn more about this enzyme and factors that can increase or decrease its activity.
CYP1A2 is an important enzyme that helps break down toxins in our bodies. It is the key enzyme responsible for metabolizing caffeine, and therefore variations in the CYP1A2 gene have a big impact on how coffee will affect our bodies. CYP1A2 gene variants have also been associated with diabetes, bone density, and cancer. Read on to find out more about this enzyme, and the natural substances that can increase or decrease it.
CYP1A1 is an important enzyme involved in detoxication of toxic substances from our bodies. However, CYP1A1 can also activate some toxic compounds into cancer-causing agents. Some CYP1A1 gene variants make people more susceptible to certain kinds of cancer. Read on to find out more about CYP1A1, its genetics, and the natural substances that can increase or decrease CYP1A1.