CYP17A1 Enzyme: Function, Gene Variants, and Ways to Decrease It

CYP17A1 is an important enzyme for the production of steroid hormones, including testosterone and estrogen. CYP17A1 gene variants are associated with elevated blood pressure, cardiovascular disease, Alzheimer’s and cancer risk. Read on to find out more about CYP17A1 function, genetics and factors that decrease enzyme activity.

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CYP11A1 Enzyme: Function, Gene Variants and Ways to Increase or Decrease It

CYP11A1 is essential for the production of steroid hormones (estrogen, testosterone, aldosterone, cortisol). It converts cholesterol into pregnenolone, from which all other steroid hormones are made. CYP11A1 also acts as an anti-inflammatory but pro-allergic agent. Read on to learn more about CYP11A1 function, gene variants and factors that increase or decrease it.

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CYP2D6 Enzyme: How it Affects Your Brain

CYP2D6 is one of the most important detoxication enzymes. CYP2D6 is responsible for the clearance of 20% of clinical drugs, including opioids (codeine, tramadol), antitumor drugs (tamoxifen), antidepressants (fluoxetine), and antipsychotics (haloperidol). In addition, CYP2D6 also metabolizes dopamine and serotonin, and the activity of this enzyme is often associated with human personality, behavior, and disease susceptibility. Read on to find out more about CYP2D6 function, gene variants, and supplements that increase or decrease CYP2D6 activity.

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CYP2C19 Enzyme: Drugs, Gene Variants, and Inhibitors

CYP2C19 is an important detoxication enzyme responsible for clearing approximately 10% of commonly used clinical drugs, including antidepressants (citalopram), proton pump inhibitors (omeprazole), and antiplatelet drugs (clopidogrel/Plavix). Elevated CYP2C19 activity is associated with depression. Read on to find our more about CYP2C19 function, gene variants, and supplements that decrease CYP2C19 activity.

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CYP2C9 Enzyme: Drugs, Gene Variants, and Inhibitors

CYP2C9 is an important drug-metabolizing enzyme. It is responsible for the clearance of up to 15-20% of clinical drugs, including antidiabetics (tolbutamide), antiepileptics (phenytoin, valproate), antihypertensive drugs (losartan), and anticoagulants (warfarin). CYP2C9 gene variants greatly affect the way we react to these drugs. Learn more about CYP2C9 function, genetics, and factors that increase or decrease CYP2C9 activity.

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54 Natural Supplements, Agonists and Drugs to Increase Dopamine (and 12 things to AVOID)

Dopamine is the compound that fuels our drive and motivation. It increases attention, improves cognitive function, and stimulates our creativity. It makes us more social and extroverted and helps us form romantic and parental bonds. However, dopamine, when too high, can also have its drawbacks. Read on to discover 54 ways to increase dopamine and 12 factors that decrease it.

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Bromantane

Bromantane, or Ladasten, is a chemical made by Russians in the 80s from amantadine combined with bromobenzene [R] and is good enough to be banned in the Olympics since 1996.

Bromantane is widely used in Russia for performance enhancing and for anti-inflammation [R] and is well-known for maintaining a high working capacity [R] and to shorten recovery times after exercise [R].
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