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5 Interesting Uses of Chlorine Dioxide + Safety, Side Effects

Written by Puya Yazdi, MD | Last updated:
Jonathan Ritter
Medically reviewed by
Jonathan Ritter, PharmD, PhD (Pharmacology) | Written by Puya Yazdi, MD | Last updated:

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Chlorine dioxide is a strong anti-infectious agent. It is antibacterial, antiviral, and can help improve oral health. Read more to learn about the health benefits and side effects of chlorine dioxide.

What is Chlorine Dioxide?

Chlorine dioxide (ClO2) is a yellow-green gas that was discovered in 1814. Since the early 1900s, people have been using it as a disinfectant [1, 2].

Chlorine dioxide is an oxidant. This means that chlorine dioxide removes electrons from another compound during a chemical reaction. This activity makes it toxic to many bacteria and fungi [2, 3, 4].

Chlorine dioxide is considered potentially toxic to humans at concentrations higher than 0.8 mg/L. Water purification tablets containing chlorine dioxide are marketed to campers, hikers, and backpackers to sanitize fresh water from rivers or lakes; make sure to carefully follow the instructions on the package if you use these products, and never use more than the recommended quantity per volume.


Chlorine dioxide acts as an oxidizing agent (gains electrons during chemical reactions) and interacts with cell components [5].

By taking electrons from microbes, the microbe’s molecular bonds weaken and the cell breaks apart. This process alters the proteins involved in their structure and decreases enzyme function, thus resulting in the death of the microbe [5].

This attack on many proteins simultaneously prevents the microorganisms from mutating and developing resistance [6].

Uses of Chlorine Dioxide

1) Antimicrobial Activity

Chlorine dioxide is frequently used to sterilize water and make it safe to drink. The maximum safe limit for chlorine dioxide in drinking water, according to the EPA, is 0.8 mg/L [7].

Chlorine dioxide gas can go through bacterial cell membranes and cause cell death in the pH range of 3-9 [4, 8].

In lab tests, chlorine dioxide was more effective at inactivating fungal spores than chlorine. It inactivated fungal spores by damaging the cell wall and cell membrane, thus causing the leakage of cell substances and eventually, fungal death [9].

In another study, a chlorine dioxide solution reduced 98.2% of bacteria and fungi in a lab test (E. coli, Staphylococcus, Pseudomonas, listeria, salmonella, Candida albicans, etc) [3].

A Powerful Disinfectant

The antimicrobial properties of chlorine dioxide are used to disinfect food, surgical tools, and more [10, 11, 9].

Low concentrations of chlorine dioxide are effective in reducing E. coli present in water. Various chlorine dioxide products can help disinfect water and produce safe drinking water [12].

In a 30-month prospective study, chlorine dioxide-treated water in a hospital decreased Legionella bacteria counts. Additionally, there were no patients that acquired Legionnaires disease during the study [13].

The bacteria on vegetable seed sprouts can cause stomach problems and disease outbreaks. Chlorine dioxide treatment and dry heating eliminated E. coli on radish seeds without damaging the seeds. Thus, it can help with food safety [11].

Chlorine dioxide treated-water significantly reduced Escherichia coli (E. coli) bacteria counts on baby spinach. However, non-culturable cells (bacteria that do not grow or divide) were still present. The treatment did not affect the quality of the baby spinach, but it reduced its photosynthetic abilities [12].

In a pilot study, chlorine dioxide gas disinfected gastrointestinal endoscopes, an instrument used to look at the inside lining of the digestive tract. The gas completely inactivated bacterial cells and disinfected all endoscopes [10].

Improving Air Quality

Chlorine dioxide gas efficiently disinfected and improved air quality indoors after single (0.28L solution, 250 mg/L), double, and triple doses. All three doses reduced indoor bacteria and fungi concentrations, but the double and triple doses had significantly better antimicrobial effects [14].

In another study, a chlorine dioxide-based agent was more effective than hydrogen peroxide at killing bacteria that had enhanced resistance to chemical and radiation disinfection (B. pumilus SAFR-032 and Bacillus subtilis ATCC 6051). Chlorine dioxide can help sterilize peroxide- and UV-resistant spores in hospital environments [15].

In another study, chlorine dioxide decontaminated known pathogens that can cause infections in a hospital room. Although each hospital room had lower bacteria counts, 2 cleaning cycles failed to completely inactivate all harmful organisms [16].

Oral and Dental Health

In a week-long study (DB-RCT) of 15 subjects, a mouthwash containing chlorine dioxide decreased bad breath (more than the placebo). It also reduced the number of chemical compounds with distinct bad smells (hydrogen sulfide, methyl mercaptan, and dimethyl sulfide) [17].

The chlorine dioxide mouthwash also reduced plaque and bacteria that cause gum disease (Fusobacterium nucleatum) in saliva [17].

In another study (TB-RCT) of 25 healthy subjects, mouthwash containing chlorine dioxide was as effective as an antibacterial mouthwash (chlorhexidine). There was no significant difference in plaque concentration or bacteria count. Although the chlorhexidine mouthwash initially had a lower bacteria count, there was no statistically significant difference [18].

Chlorine dioxide may also help whiten teeth. It was faster at whitening cow teeth than hydrogen peroxide. However, since it has a low pH, long-term exposure may harm teeth [19].

A 5% chlorine dioxide solution can also help clean the mouth during root canals due to its antimicrobial properties [4].

Chlorine dioxide mouthwashes are available for purchase. If you use one, take special care not to swallow the solution, as the concentration of chlorine dioxide in these products is much higher than the threshold for safe consumption.

2) Antiviral Activity

Chlorine dioxide is also antiviral. It destroys the proteins on the outside of viruses and degrades the virus [20].

Chlorine dioxide gas is effective against [21]:

  • Human influenza (IFV)
  • Measles
  • Human herpes (HHV)
  • Human adenovirus (HAdVs)
  • Influenza A (in mice) [20]

Chlorine dioxide solution also inactivated human and monkey rotaviruses (that cause diarrhea) and hepatitis A [22, 23].

Negative Effects of Chlorine Dioxide

1) Cell Damage & Neurotoxicity

Normally, exposure to low amounts of chlorine dioxide is safe for humans. In a study of 17 dialysis patients, 1 month of exposure to chlorine dioxide-treated water did not have any toxic effects or cause anemia (low red blood cell levels) [24].

However, in rats, chlorine dioxide gas altered the structure of blood cells and prevented DNA formation in several organs. The changes in blood cells caused mild hemolytic anemia, a condition in which blood cells are destroyed and removed before their normal lifespan is over [25].

Additionally, an oral dose of 14 mg in rats damaged proteins in their brain cells, demonstrating a potential for neurotoxicity [26].

2) Contamination

Chlorine dioxide products also tend to contain high levels of impurities (reactants with additional compounds). These products are useful for wastewater treatment but dangerous when in contact with humans or food [27].

Impurities are mainly caused by other chlorine compounds, such as chlorine and chloroxy anions (ClO2- or ClO3-). They can react with organic matter to form trihalomethane, a compound that causes cancer (carcinogen) [25].

Safety Data & Side Effects

There are only a few human studies available on the effects of chlorine dioxide.

People with G6PD deficiency may have a higher risk of developing anemia due to chlorite exposure from chlorine dioxide [24].


Chlorine dioxide is unstable as a gas and is explosive in concentrations greater than 10%. It can be ignited by almost any form of energy, including sunlight and heat [28, 29].

Chlorine dioxide is toxic and can burn or severely irritate the skin and eyes in high concentrations [30].

The Occupational Safety and Health Administration states that the highest exposure to chlorine dioxide in the air should be 0.1 ppm and 0.3 mg/m3 [31].

Drinking water containing more chlorine dioxide than the toxic threshold (0.8 mg/L) may cause kidney damage [32].

Drug Interactions

Diclofenac is a drug that treats pain, arthritis, and migraines (NSAID). In water, chlorine dioxide can degrade diclofenac. While this is beneficial during water treatment (preventing trace amounts of drugs from persisting in drinking water), its effects on the human body are unknown [33].


Chlorine dioxide can be found in a gaseous, liquid, or solid state [34, 30, 35].

The best way to store chlorine dioxide is as a liquid/ dissolved gas at 4ºC. Chlorine dioxide cannot be stored for too long, because it slowly separates into chlorine and oxygen [36].

Miracle Mineral Solution

Miracle Mineral Solution is a product that contains sodium chlorite, which reacts with an acid (like lemon juice) to form chlorine dioxide. The creator claimed that it can cure AIDS, cancer, hepatitis, malaria, and autism [37].

If it sounds like snake oil to you, you’d be right. MMS is considered wildly unsafe and has been reported to cause [37]:

  • Nausea
  • Dehydration
  • Severe vomiting
  • Diarrhea
  • Low blood pressure (hypotension)
  • Death

In one case, a patient developed Kikuchi-Fujimoto disease after drinking an unknown amount of the miracle mineral solution. The solution triggered an inflammatory response and caused fever, night sweats, and swollen lymph nodes [37].

It is banned in the US, UK, and Canada. The FDA has released specific warnings about the potentially life-threatening side effects of MMS. We strongly advise against using this product for any reason [38].

About the Author

Puya Yazdi

Puya Yazdi

Dr. Puya Yazdi is a physician-scientist with 14+ years of experience in clinical medicine, life sciences, biotechnology, and nutraceuticals.
As a physician-scientist with expertise in genomics, biotechnology, and nutraceuticals, he has made it his mission to bring precision medicine to the bedside and help transform healthcare in the 21st century. He received his undergraduate education at the University of California at Irvine, a Medical Doctorate from the University of Southern California, and was a Resident Physician at Stanford University. He then proceeded to serve as a Clinical Fellow of The California Institute of Regenerative Medicine at The University of California at Irvine, where he conducted research of stem cells, epigenetics, and genomics. He was also a Medical Director for Cyvex Nutrition before serving as president of Systomic Health, a biotechnology consulting agency, where he served as an expert on genomics and other high-throughput technologies. His previous clients include Allergan, Caladrius Biosciences, and Omega Protein. He has a history of peer-reviewed publications, intellectual property discoveries (patents, etc.), clinical trial design, and a thorough knowledge of the regulatory landscape in biotechnology. He is leading our entire scientific and medical team in order to ensure accuracy and scientific validity of our content and products.

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