C60 is still relatively new, with only limited studies. C60 oil showed promising antioxidant and lifespan-increasing effects in rats and dishes. However, early studies show it may also induce DNA mutations. What’s more, C60 completely lacks clinical trials. Read on for a breakdown of available science behind C60.

Disclaimer: Clinical studies have yet to determine the effectiveness and safety of C60. Thus, C60 has a high potential for harm, with unknown risks and side effects. We suggest against supplementat/.

ion until proper clinical trials determine the effectiveness and safety profile of this substance.

What is C60?

New Antioxidant

Buckminsterfullerene, buckyballs, or C60 is a powerful antioxidant that has effects on unsaturated fats. it removes superoxide, which is a toxic by-product of cellular metabolism that contributes to tissue injury in many human diseases [1].

A review of scientific research concluded that C60 early research holds some promise. The compound had longevity and antioxidant effects in animals and cells. However, it’s still far too soon to draw any conclusions from such limited data [2].

The proposed mechanism indicates that C60 has the ability to acquire positive charge by absorbing protons; this complex could enter the mitochondria, leading to a decrease in reactive oxygen species production [3].

Computer simulations have shown that C60 has the ability to pass through lipid membranes, enter the cell, and alter its functions [4].

Some C60 derivatives that are produced in the body are water-soluble and apparently non-toxic below concentrations of 1 mg/mL [5].

Snapshot

Proponents

• May promote longevity
• May reduce oxidative stress and inflammation
• Kills microbes
• Shields the skin and nerve cells

Skeptics

• May cause DNA mutations
• Not studied in humans at all
• Side effects profile and interactions unknown
• High potential for harm
• Both short- and long-term safety is unknown

C60 Research

1) May Promote Longevity

Carboxyl C60 prevented nerve cell death from dehydration or amyloid-beta plaques (cause Alzheimer’s) and allowed mice to live 8 days longer in a 120-day lifetime [6, 7].

Another study found that average lifespan can increase 5-14% even when starting halfway through the lives of mice [8, 9].

The above studies used a derivative of C60 while using the real thing in olive oil (1.7 mg/kg, 2x a month) can produce a 90% increase in rats’ lifespan [10].

However, it’s completely uncertain if C60 has any effect on