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What Doctors Won’t Tell You About Low or High Ferritin in Your Blood Test

Ferritin stores iron and transports it to where it is required. In blood, it is an important indicator of the total iron stores. However, ferritin also participates in infections, inflammation, and malignancies. Elevated ferritin is often found in disorders with chronic inflammatory states such as obesity, metabolic syndrome, and diabetes. Find out why it is important to keep this protein in balance, and which factors increase or decrease ferritin levels.

Contents

Introduction

Ferritin is a spherical protein complex. It is the primary iron-storage protein within the cell, that stores iron in a soluble, non-toxic form, and can transport it to areas where it is required (R).

Iron can be toxic to cells because of its capacity to generate reactive species which can directly damage DNA and proteins. Ferritin captures and buffers the iron within cells, and is very important for our survival (R).

Mice deficient in ferritin die in the embryo stage (R).

Ferritin is found in most tissues where it is located inside the cells. Within the cells, ferritin is mostly found in the cellular fluid (cytosol), nucleus or mitochondria (R).

Mitochondrial ferritin (FtMt) is produced by specific tissues such as the testis and the brain (R).

Small amounts of ferritin are also secreted into the blood where it functions as an iron carrier. Apart from the blood, ferritin is also secreted into joint (synovial) and spinal fluids (R).

The liver’s stores of ferritin are the primary source of reserve iron in the body (R).

 

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717717/

As previously mentioned, ferritin plays an important role in the storage of cellular iron (R). It functions in cell detoxification, limiting the formation of reactive oxygen species, and mitigating their damaging effect on cellular structures (R).

By capturing toxic metal ions, ferritin is involved in the antioxidant system of cell defense. Apart from iron, ferritin also regulates the cellular concentration of other transition metals, including beryllium, aluminum, zinc, cadmium and lead (R).

On the other hand, ferritin outside the cell can function as a highly efficient iron delivery mechanism. Compared to another iron carrier – transferrin, which carries a maximum of 2 iron atoms, a single ferritin molecule can sequester up to 4500 iron atoms (R).

Blood ferritin, which is believed to be iron-poor, carries much less iron than this, but could nevertheless make a significant impact on iron delivery (R).

Ferritin acts as a buffer against iron deficiency and iron overload (R).

Additionally, it was shown that circulating ferritin may assume roles entirely independent of its classic role as an iron binding protein (R).

Ferritin is may play an important role in the skin defence. Ferritin in the skin is increased by UVA and infrared-A radiation. Increased ferritin following acute UV/IR radiation could afford increased protection against subsequent oxidative stress (R,R).

Ferritin is an acute phase reactant and a marker of acute and chronic inflammation and is nonspecifically elevated in a wide range of inflammatory conditions (R).

One study suggests that blood ferritin actually originates from damaged cells and thus reflects cellular damage (R).

Ferritin can behave as a real pro-inflammatory cytokine, activating the NFκB cascade and inducing liver damage (R).

Ferritin can modulate immune function by inhibiting lymphocyte function. Ferritin decreased the number of granulocyte-macrophages, and red blood cell precursors in mice (R).

Ferritin has also been shown to suppress immune activity in humans (R).

Ferritin can stimulate blood vessel growth in inflammation, desirable in wound healing, but undesirable in tumors (R).

Unless indicated otherwise, the statements in the text below refer to the circulating ferritin found in blood.

Joe’s Experience With Ferritin

Most of my client population have lower ferritin and this is usually because of some kind of intestinal inflammation that is not allowing the person to absorb iron well, as well as hypothyroidism.

Indeed, research shows that people with IBD, fatigue, hypothyroidism and fibromyalgia have lower ferritin, which are common groups among my clients.

When iron (indicated by ferritin) is lower, it can contribute to and exacerbate existing health problems, so you want to get that fixed.

I myself had ferritin on the lower end of the range when I wasn’t as healthy (about 40-50).

Some people are trying to get ferritin to 20 ng/ml for “anti-aging purposes”, but given the research cited here, that’s a big mistake.

I personally try to get my ferritin levels over 90 ng/ml, especially because I’m Th1 dominant and more iron is better for me.

Recommended Supplements for Increasing Ferritin/Iron Status Without Gut Problems

Optimal Reference Range for Ferritin

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Blood ferritin is an indirect indicator of the total amount of iron stored in the body. Therefore, blood ferritin is used as a diagnostic test for iron-deficiency anemia (R).

Ferritin is normally high at birth. Ferritin levels rise during the first two months of age and then fall until the end of the first year of life, i.e. later infancy. At about one year of age, ferritin levels begin to rise again (R).

Normal ferritin blood levels:

  • Men: 18-270 or 30-300 nanograms per milliliter (ng/mL)*
  • Women: 18-160 or 10-200 ng/mL*
  • Children (6 months to 15 years): 7-140 ng/mL
  • Infants (1-5 months): 50-200 ng/mL
  • Newborns: 25-200 ng/mL
  • reference ranges for blood ferritin vary across laboratories, but generally levels of 30 to 300 ng/ml are considered normal for men, and 10–200 ng/ml for women (R).

Note that ferritin has been shown to increase in response to stress, such as inflammation or infection. These conditions may change what would otherwise be low ferritin indicating a lack of iron, into a value in the normal range.

Ferritin Deficiency

Blood ferritin anywhere below 12 to 30 ng/ml indicates depletion of iron stores and is a diagnostic criterion for iron deficiency (R,R).

Because it also behaves as an acute phase protein, the levels of ferritin can go up several-fold in response to stress and infections or inflammatory states (R). In these cases, ferritin stops being an accurate indicator of iron deficiency.

Some studies state that the traditional cutoff point of 12 and 30 ng/ml is too low to detect iron deficiency anemia in the general population, but especially for those with inflammatory or liver diseases. A level higher than approximately 40 ng/ml was suggested to exclude iron deficiency in most patients, and a level higher than 70 ng/ml was suggested to exclude iron deficiency in patients with inflammation or liver diseases (R).

Other than anemia, low ferritin may also indicate hypothyroidism, vitamin C deficiency or celiac disease (R,R).

Vegetarians can have significantly lower blood ferritin levels, resulting from iron deficiency. One study found iron deficiency in 19% of vegetarians (R).

Ferritin Excess

If ferritin is high, there is iron in excess or else there is an acute inflammatory reaction in which ferritin is mobilized without iron excess.

Ferritin is increased under oxidative stress. It is increased by the antioxidant-responsive element (ARE) (R).  Ferritin, in turn, can increase liver proinflammatory mediators IL-1b, iNOS, RANTES, IkappaBα, and ICAM1 (R).

Ferritin is used as an indicator for iron overload disorders, such as hemochromatosis or hemosiderosis.

As ferritin is also an acute-phase reactant (a part of body’s response to inflammation), it is often elevated in various diseases. A normal C-reactive protein (CRP) can be used to exclude elevated ferritin caused by acute phase reactions.

Ferritin levels of greater than 1000 ng/ml are a nonspecific marker of illness, including infections and cancer (R).

However, ferritin over 300 can indicate some inflammation.

Diseases Associated With Higher Ferritin

Circulating ferritin is widely recognized as an acute phase reactant and a marker of acute and chronic inflammation. It is  elevated in a wide range of inflammatory conditions, including chronic kidney disease, rheumatoid arthritis and other autoimmune disorders, acute infections, and malignancy (R).

Common causes of elevated ferritin levels also include obesity, diabetes, metabolic syndrome and daily alcohol consumption (R,R).

The elevated ferritin in these states reflects increased total body iron storage, but paradoxically, these stores are sequestered and not available for red blood cell production.  This contributes to the widely recognized anemia of chronic disease (ACD) (R).

Note that although ferritin levels generally increase in infection, some infections can also result in decreased ferritin (R).

Ferritin is Elevated in Anemia of Chronic Disease (ACD)

Anemia of Chronic Disease is the most frequent anemia in hospitalized patients. It develops in subjects suffering from diseases that are associated with chronic activation of cell mediated immunity, such as chronic infections, immune mediated inflammatory disorders, or malignancy (R).

A hallmark of ACD is a decrease in available iron, limiting the production of red blood cells. Meanwhile, iron is taken up by macrophages and dendritic cells. Thus ACD can be easily diagnosed by the presence of low iron, but increased blood levels of ferritin (R).

Pure iron deficiency is recognized by low ferritin and transferrin saturation but increased transferrin concentrations. Patients with “classical” ACD present with increased ferritin levels while transferrin concentrations as well as transferrin saturation are reduced. In contrast, all of these parameters are decreased in ACD patients with iron deficiency (R).

Combined treatment of ACD in subjects with active rheumatoid arthritis with iron and erythropoietin (Epo) significantly reduced disease activity (R).

Higher Ferritin is Associated With Diabetes

Elevated levels of ferritin may help identify individuals at high risk of type 2 diabetes (R).

In one study, subjects with elevated ferritin had a 2.4-fold higher risk of developing type 2 diabetes (R).

High ferritin was associated with elevated fasting blood glucose, hemoglobin A1c (HbA1C), CRP, and the SAD (Standard American Diet) diet in diabetic patients (R).

Higher Ferritin is Associated with Metabolic Syndrome

In certain situations, elevated ferritin levels are found in patients with metabolic syndrome (R).

This elevated ferritin in subjects with metabolic syndrome is associated with insulin resistance and fatty liver but not with iron overload (R,R,R).

Elevated ferritin levels were also associated with central obesity, high blood pressure, and high cholesterol/triglycerides, all manifestations of the metabolic syndrome (R).

Significant correlations were found between ferritin concentration and metabolic syndrome parameters (HDL cholesterol, triglycerides, and fasting glucose) as well as an increase in the ferritin value with the number of risk factors of metabolic syndrome in healthy men (R).

Also, oxidative stress markers (carbonyl groups, AOPP, and glycated hemoglobin), liver damage markers (GGT, SGOT), and parameters related to insulin resistance (HOMA, blood insulin, and blood glucose) correlate significantly with ferritin (R).

High Ferritin is Associated With Atherosclerosis

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Ferritin is not only a marker of insulin resistance but also one of the strongest risk factors for the progression of hardening of the arteries (atherosclerosis) (R).

It was linked with artery stiffness in apparently healthy Korean women (R).

Ferritin was also associated with clogged arteries in a large group of NAFLD patients (R).

Ferritin is Elevated in Anorexia

Ferritin can be elevated in anorexia, during periods of acute malnourishment. In anorexia patients, elevated ferritin decreases as patients gain weight and improve their BMI (R).

Ferritin is Higher in Grave’s

In patients with thyrotoxic Graves’ disease, ferritin is higher and decreases back to normal when normal thyroid function is achieved by antithyroid drug therapy (R).

High Ferritin May Contribute to Heart Arrhythmia

Ferritin and iron levels are associated with electrocardiogram findings in acutely ill patients. High ferritin contributes to abnormal heart electrical activity in a variety of medical conditions, and possibly contributes to the emergence of fatal heart arrhythmias (R).

Higher Ferritin is Associated With Cancer (most of the time)

Ferritin is elevated in many malignancies (R,R,R).

Although ferritin is elevated in these states, iron stores are not available for producing red blood cells, causing anemia of chronic disease (ACD) (R).

This relative iron deficiency in inflammation and malignancy is presumed to have developed as a defense mechanism to restrict iron utilization by tumors/pathogens (R).

However, some cancers are also associated with low levels of ferritin, such as colon cancer (R).

Ferritin is High in Sideroblastic Anemia

Sideroblastic anemia is a disorder in which there is a failure to produce healthy red blood cells. A common manifestation of sideroblastic anemia is iron overload and elevated ferritin (R).

Higher Ferritin is Associated With Fatty Liver (NAFLD)

Elevated ferritin and mildly increased iron stores are frequently observed in patients with non-alcoholic fatty liver disease (NAFLD), where ferritin increase can reflect oxidative stress, inflammation, and liver tissue death (R).

Growing evidence proposes a correlation between ferritin, insulin resistance, and NAFLD (R).

Ferritin levels were shown to predict NAFLD incidence in healthy Korean men (R).

Higher Ferritin is Associated With Liver Damage in Hepatitis C

Higher ferritin has been shown to predict severe liver tissue damage in patients with chronic Hepatitis C infection (R).

Ferritin is High in Still’s Disease

Adult onset Still’s disease is a systemic inflammatory disorder characterized by fever, arthritis, and rash, that typically affects young women. Elevated ferritin levels were seen in 89% of these patients, nearly half of whom had levels greater than five times normal (R).

An exaggerated ferritin response with levels above 5 times the normal upper level predicted chronic Still’s disease with 100% accuracy. Ferritin was useful in distinguishing these patients from clinically similar rheumatoid arthritis patients (R).

Ferritin is High in Hemochromatosis

Genetic mutations in the hemochromatosis gene (HFE) make up the most common genetic cause of elevated ferritin levels and are usually seen in patients with northern European ancestors (R).

High ferritin robustly predicts the risk of cirrhosis, the main clinical manifestation of hemochromatosis. Several studies have shown that cirrhosis of the liver rarely occurs in hemochromatosis patients with ferritin levels below that of 1000 micrograms/liter (R).

Ferritin is Extremely High in Hemophagocytic Syndrome

Hemophagocytic syndrome (also known as macrophage activation syndrome or lymphohistiocytic syndrome) is a group of disorders with a final common pathway consisting of elevated triglycerides, elevated ferritin, deficiency of all blood cells, and multiple organ failure. The syndrome is strongly associated with autoimmune disorders, particularly systemic lupus erythematosus and Still’s disease, and viral infections, particularly Epstein-Barr virus (R).

Ferritin in hemophagocytic syndrome is classically elevated above 10,000 ng/L (R).

Diseases Associated With Lower Ferritin

Patients with iron deficiency, as measured by ferritin, have an increased risk of unipolar depressive disorder (OR = 2.34), bipolar disorder (OR = 5.78), anxiety disorder (OR = 2.17), autism spectrum disorder (OR = 3.08), attention deficit hyperactivity disorder (OR = 1.67), tic disorder (OR = 1.70), developmental delay (OR = 2.45), and mental retardation (OR = 2.70) (R).

Low Ferritin Indicates Anemia

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Low blood ferritin indicates depletion of iron stores and is a diagnostic criterion for iron deficiency and anemia (R).

Anaemia can manifest as fatigue, headache, dizziness, shortness of breath, or elevated heart rate (tachycardia), and generally lowers the overall quality of life. Motility disorder, nausea, anorexia, and even malabsorption have also been attributed to this condition (R).

A common finding in anemia is irregularity or absence of menstrual periods in women, while men may suffer from impotence. Loss of libido may contribute to impaired quality of life in both sexes (R).

Several studies have confirmed that treatment of anaemia improves cognitive function. That is because iron is a component of many essential enzymes, and therefore iron deficiency alone may impair cognitive function. Indeed, correction of iron-deficiency in non-anaemic girls was shown to improve verbal learning and memory (R).

Low Ferritin is Associated With Fatigue

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Ferritin and iron depletion can be found in some fatigue patients.

Intravenous administration of iron improved fatigue in iron-deficient, nonanemic women (R). Over 80 percent had reduced fatigue after receiving iron.

A couple of studies recommend iron supplementation for women with unexplained fatigue who have ferritin levels below 50 μg/L (R).

Ferritin is Lower in Fibromyalgia

Iron is a necessary for serotonin and dopamine production and may have a role in causing fibromyalgia.

The spinal fluid in fibromyalgia syndrome (FMS) has shown a reduction in the concentration of dopamine, norepinephrine and serotonin.

The average serum ferritin levels in the fibromyalgia 27.3 and 43.8 ng/ml in a healthy group.

Statistical analyses shows that ferritin levels below 50ng/ml caused a 6.5-fold increased risk for Fibromyalgia.

Ferritin is Lower in IBD

Chronic intestinal bleeding in inflammatory bowel disease (IBD) may exceed the amount of iron that can be absorbed from the diet, resulting in a negative iron balance (R).

In fact, anemia is a common complication associated with inflammatory bowel disease (IBD). The World Health Organization estimates that more than 30% of the population have iron deficiency anemia yet it remains an under-managed feature of many gastrointestinal conditions. Also, one third of inflammatory bowel disease (IBD) patients suffer from recurrent anemia (R).

Almost every anemic patient with IBD demonstrates some degree of iron deficiency as a consequence of dietary restrictions, malabsorption, or intestinal bleeding (R).

Both iron deficiency and anaemia of chronic disease (ACD) contribute to the development of anaemia in IBD (R).

Inflammation and ACD is why anemic IBD patients can have elevated ferritin. CRP can be used to exclude inflammation.

Chronic fatigue, a frequent IBD symptom itself, is commonly caused by anemia and may debilitate patients as much as abdominal pain or diarrhea (R).

In IBD, oral iron treatment is limited by poor absorption, intolerance, and induction of oxidative stress at the site of bowel inflammation. However, intravenous iron sucrose has a good safety profile and a 65–75% response rate within 4–8 weeks, which is paralleled by improvement in the quality of life. Additionally, combination therapy with erythropoietin (Epo) leads to a faster and larger hemoglobin increase (R).

When anemic Crohn’s disease patients were treated with iron sucrose and Epo, the feeling of well being, mood, physical ability, and social activities improved. Also, individual patients reported relief of disturbed sleep and increased appetite or libido (R).

Iron deficiency may enhance the IFNgamma response in Th1 driven inflammation in immune mediated inflammatory disorders such as Crohn’s disease (R).

High iron load lowers inflammation by decreasing TNF-a and lowering Th1 and increasing Th2 function (R).

Ferritin is Lower in Hypothyroidism

Alterations in thyroid status and activity result in changes in blood ferritin levels (R).

Subclinical hypothyroidism is associated with iron-deficiency anemia (R) and lower ferritin levels (R).

Blood ferritin levels increased in hypothyroid patients with Hashimoto’s disease when normal thyroid function was achieved with L-Thyroxine therapy (R).

In patients with Graves’ disease (higher thyroid hormones), ferritin is higher and decreases back to normal when normal thyroid function is achieved by antithyroid drug therapy (R).

Ferritin is Lower in Depression and Anxiety

The average ferritin level in students with depression was significantly lower than the healthy ones.  Low ferritin increases the odds of depression by 1.92X (R).

The study implies a possible association between depression and decreased ferritin level before the occurrence of anemia (R).

In another study, patients with iron deficiency, as measured by ferritin, have an increased risk of unipolar depressive disorder (OR = 2.34), bipolar disorder (OR = 5.78) and anxiety disorder (OR = 2.17) (R).

Low Ferritin Causes ADHD

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Iron is associated with dopamine metabolism and low iron levels might be associated with more significant impairment in dopamine function in subjects with ADHD (R).

Iron deficiency has been associated with attention and behavioral problems and ADHD.

Kids with lower ferritin (average of 18.4 ng/mL) had worse inattention, hyperactivity/impulsivity, and ADHD symptoms (R, R, R).

Children who were on ADHD meds showed a stronger association between ferritin and ADHD symptom severity (R).

These findings add to the growing literature implicating iron deficiency in ADHD (R).

Iron supplementation should be investigated as a potential intervention in individuals with low iron stores and ADHD (R).

Ferritin in Neurodegenerative Diseases

Several iron disorders that affect movement and other neurologic functions (Parkinson’s disease and restless legs syndrome) are linked to abnormalities in ferritin (R).

It could be that lower ferritin in the cell may contribute to these disorders by causing higher levels of free iron.  This may or may not be related to blood ferritin.

A rare genetic disease, neuroferritinopathy, is a result of mutations in the gene encoding a component of ferritin. It is thought that the mutations impair ferritin assembly lead to a loss of iron storage capacity within brain cells, which causes iron-mediated cell injury (R).

Mitochondrial ferritin (FtMt) has a protective role in neurodegenerative diseases (R,R). Mitochondrial ferritin lowers reactive oxygen species (ROS) accumulation and reduces cell damage in Parkinson’s and Alzheimer’s disease in animal models (R).

Ferritin is Lower in Celiac Disease

Iron depletion and low ferritin are frequent findings in patients with celiac disease (R,R).

Ferritin in Restless Legs Syndrome

Restless Legs Syndrome is a neurologic disorder characterized by unpleasant sensations in the legs that appear mostly at night upon retiring, including an irrepressible urge to move the limbs (R).

It was suggested that patients with restless legs syndrome have lower ferritin levels in spinal fluid and parts of the brain (R).

Factors that Elevate Ferritin

In normal subjects, daily iron loss amounts to 1–2 mg and this requires a similar amount of iron to be taken up from the diet (R).

Menstruating women lose more blood than their male counterparts and are therefore at higher risk of iron deficiency (R).

1) Iron Supplements

Supplementing with 30 mg/d of iron for 90 days increased ferritin concentration in schoolchildren with low iron stores, and this effect persisted 6 months after supplementation (R).

Oral iron supplements commonly contain iron in the form of ferrous salts (ferrous sulphate, ferrous gluconate, and ferrous fumarate). All ferrous compounds are oxidized in the gut, releasing reactive radicals as byproducts. These will attack the gut wall and produce a range of gastrointestinal symptoms and discomfort (R). This problem is especially pronounced in IBD patients where oral iron may enhance gut inflammation (R).

Ferric iron polymaltose complex or heme iron polypeptide are also available, and may present safer and better tolerated alternatives (R).

Another good alternative is intravenous iron supplementation (R).

2) Iron-rich Foods

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  • Dietary iron occurs in two forms: heme (from meat, poultry, and fish) and non-heme (mostly from plants) (R).
  • Non-heme iron absorption depends on many factors, including the presence of stomach acid and Vitamin C.  Inhibitors such as phytic acid and polyphenols (in vegetables) reduce non-heme absorption (R).
  • Heme iron is released after mechanical and enzymatic digestion of myoglobin found in meat and fish (R).

Consuming iron-rich foods improves iron stores and ferritin levels. These include green leafy vegetables, cocoa powder and dark chocolate, oatmeal, cereals, wheat germ, beans and tofu, lamb and beef, nuts, pumpkin and squash seeds, liver and mollusks, etc.

Red meat consumption correlates significantly with ferritin in the blood (R).

3) Vitamin C

Vitamin C (ascorbic acid) increases the bioavailability of iron and its absorption from dietary sources (R).

Ascorbic acid uptake induces both iron-independent and iron-dependent ferritin production (R).

4) Alcohol

Alcohol enhances the absorption of iron.

Alcohol consumption is significantly associated with levels of ferritin (R).

There was a positive relationship between wine intake and concentrations of both ferritin and iron in the blood (R).

In alcohol abuse, ferritin levels are elevated and rapidly decrease with alcohol abstinence (R).

5) Smoking

Women who smoke have higher ferritin and higher body iron compared to nonsmoking women. However, when women smoke during pregnancy, their newborn infants have lower iron stores than those of non-smoking mothers (R).

Tobacco smoking was associated with elevated ferritin concentrations in Parkinson’s disease patients (in this setting smoking had a beneficial effect) (R).

6) Proinflammatory Cytokines

Pro-inflammatory cytokines stimulate the production of ferritin, which in inflammation/infection acts as an acute phase reactant (R).

Circulating ferritin production is increased by the cytokines interleukin-1-β (IL-1) and tumor necrosis factor-α (TNF-α) (R).

7) L-alanine

lL-alanine also increases ferritin (R).

Factors that Decrease Ferritin

Because there is no excretory route, iron level is regulated by iron uptake. If iron absorption is not tightly regulated, iron overload and associated toxicity occur (R).

1) Dairy Products

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Calcium-rich foods, such as dairy products, may decrease the absorption of iron.

Ferritin levels were negatively associated with the amount of cows’ milk consumed and calcium intake in 18-month old children (R).

Pregnant women who had consumed cow’s milk at least 3 times a week had lower levels of ferritin and body iron (R).

A diet rich in milk and yogurt increased the risk of low iron status by 50 percent in women in New Zealand (R).

However, although some short-term effects have been observed, long-term calcium supplementation was not observed to negatively impact iron status and ferritin concentration (R).

2) Coffee

Coffee interferes with the utilization of supplemental iron (R).

Pregnant women with a high frequency of coffee consumption had lower values of body iron (R,R).

3) Tea

Tea contains tannins which inhibit the absorption of iron. However, tea does not seem to impact ferritin levels in healthy adults. It may only lower ferritin in those with iron deficiency or iron overload.

Ferritin concentrations were not related to black, green or herbal tea consumption in healthy adults (R).

However, ferritin displayed a negative correlation with the consumption of tea in elderly (R).

In groups with high prevalence of iron deficiency, tea consumption was associated with lower ferritin (R).

In those at risk for iron overload, tea consumption may lower ferritin concentrations (R).

4) Fiber

Fiber impairs the absorption of iron.

Intake of fiber-poor fruits, vegetables, and juices were associated with higher ferritin concentrations in premenopausal women (R).

5) Exercise

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Ferritin increases acutely immediately after exercise but returns to baseline a few hours later (R).

On the other hand, long term, routine exercise lowers ferritin along with other acute phase reactants (R).

Regular physical activity, especially extensive running, increases iron loss. Mild iron deficiency (abnormal blood ferritin and normal hemoglobin concentration) and sometimes true iron deficiency anemia can occur especially when nutritional iron intake is insufficient and iron demand is increased because of growth (children, adolescents) or additional iron loss (by menstruation) (R).

Iron deficiency is common in athletes involved in endurance sports. In female marathon runners, the prevalence is as high as 28%, compared to 11% in the general female population (R).

Endurance athletes need more iron because their training causes an expansion in the amount of red blood cells. This means that their hemoglobin levels may seem normal but their ferritin levels (a marker of the iron reserves stored in the body) may be low.

Low ferritin with hemoglobin in the mid- to upper normal range, and low ferritin with hemoglobin in the low normal range are relative indications for iron supplementation in athletes (R).

6) Blood Donation

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Ferritin levels are lowered after donating blood.

Decrease in ferritin is dependent both on the number of blood donations as well as the periodicity between them (R).

7) Estrogen and Progestin Hormone Therapy

Estrogen may lower ferritin.

Current users of oral conjugated estrogen plus progestin had significantly lower ferritin concentrations than did current users of estrogen only (R).

Longer times since menopause and longer times since the last hormone use were associated with higher ferritin concentrations (R).

8) Aspirin

Subjects who took >7 aspirins/week had significantly lower ferritin than nonusers, who took <1 aspirin/week (R).

This effect of aspirin on ferritin was more marked in diseased subjects with inflammation, infection or liver disease (R).

9) Risedronate

Risedronate treatment is associated with significantly decreased ferritin levels in postmenopausal women with osteoporosis and cardiovascular risk factors (R).

Recommended Supplements for Increasing Ferritin/Iron Status Without Gut Problems

Authors:

This post was cowritten by Joe and researcher with a PhD in Biology.

Comments

  1. inom

    I have low Ferritin with possible gut inflammation. Which supplement would be better? I have heard carbonyl form is safer and good for those with less stomach acid. I am chronically sick with sensitivity of most of the foods.

    • Nattha Wannissorn

      My advice is to fix the gut inflammation by testing for what could be causing the gut to be inflamed (i.e. stool screening for pathogens and organic acids). Otherwise, what you are doing is just controlling the symptoms (which includes avoiding the foods you are sensitive to), and you will not absorb much of the supplements and foods that you ingest. We can reasonably expect that all your other symptoms (if any) will improve once you kill the gut pathogens, re-balance the gut flora, and fix the leaky gut. If you would like help on this, you can book an appointment with me at https://selfhacked.com/consult-specialists/#Nattha_bio. We’ll chat about what’s going on, decide what tests are best for you, and help you on your way to health. ~Nattha @ Team SelfHacked

  2. Cindi

    Great post, but it’s still not clear to me whether someone with high inflammation/metabolic syndrome should intentionally lower ferritin levels. Are they rising as a protective mechanism, or is the high ferritin contributing to the problem?

    • Nattha Wannissorn

      More like the body is trying to conserve iron because it’s preparing to lose blood in the presence of inflammation (said one of the doctors I learned this stuff from).

    • Natcha M

      Things that prevent absorption like tannins and phytates. I think you better get those in foods rather than supplementing them. Also gotta eat less iron in the first place.

  3. Shelley Goforth

    This is wonderful information! I appreciate you and your contribution to our understanding of our bodies so much.

  4. Remy

    Ferritin can be normal or high in the Anemia of Chronic Disease. A better way to differentiate is transferrin/TIBC. If it is low, it’s more likely ACD. If it’s high, iron deficiency anemia.

    • Natcha M

      Yes Remy, I agree. Unfortunately those things rarely get tested unless the doctor is following up on someone with a diagnosis. We definitely should have a comprehensive iron levels post.

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