Evidence Based This post has 23 references If you buy something through a link on this page, we may earn a small commission. How this works.
4.2 /5

Baicalin & Baicalein: Potential Benefits & Upcoming Research

Written by Joe Cohen, BS | Last updated:

Baicalin and baicalein are flavones under investigation for potential benefits to the nervous system & in rheumatoid arthritis. Learn more here.

What are Baicalin and Baicalein?

Baicalein is a flavone, a type of polyphenolic flavonoid, that is extracted from the roots of Scutellaria baicalensis and Scutellaria lateriflora that have a wide variety of health benefits.

Baicalin is a flavone glycoside, the glucuronide of baicalein, which is obtained through the binding of glucuronic acid to baicalein. It is primarily used in Asian countries as an herbal supplement.

Potential Health Benefits

Baicalin and baicalein supplements have not been approved by the FDA for medical use and generally, lack solid clinical research. Regulations set manufacturing standards for them but don’t guarantee that they’re safe or effective. Speak with your doctor before supplementing.

SelfDecode has an AI-powered app that allows you to see how Baicalin benefits your personal genetic predispositions. These are all based on clinical trials. The orange neutral faces denote a typical genetic risk of developing conditions that Baicalin counteracts.

Possibly Effective For

1) Rheumatoid Arthritis & CAD

In one study of 374 patients with rheumatoid arthritis and coronary artery disease (which are frequently comorbid), 500 mg of baicalin per day significantly reduced blood lipids and markers of inflammation [1].

Animal Research (Lacking Evidence)

No clinical evidence supports the use of baicalin for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies listed below should not be interpreted as supportive of any health benefit.

2) Anxiety

Baicalein and baicalin inhibited the action potential of the neurons that raise anxiety [2].

In mice, baicalin produced anxiety-lowering effects without causing drowsiness or muscle relaxation [3].

3) Neuroprotection

Baicalin improved cognitive dysfunction in mice via its anti-neuroinflammatory activity, leading authors to suggest it as a potential candidate for the treatment of Alzheimer’s Disease (AD) [4].

It improved Amyloid beta-induced learning and memory deficit, hippocampus injury and neuron apoptosis (mice) [5].

Baicalin improved learning and memory impairment induced by brain injury in mammals [6].

Treatment with this flavonoid in animals, post-stroke, promoted neuron development in damaged sections of the brain, including the new formation of cells in the hippocampus [7].

4) Liver

Baicalin administered in rats reduced the effects of fatty liver disease (by increasing PPAR gamma and insulin receptors) [8].

It decreased cholesterol, alanine transaminase, low-density lipoproteins, and TNF levels.

Rats with alcohol-induced liver damage treated with this flavonoid before consuming alcohol had protective effects on the liver. It also decreased liver cell apoptosis [9].

5) Lung Function

Pure baicalin improved lung function in rats suffering from allergic diseases [10].

When administered to rats suffering from asthma as a pretreatment, baicalin stimulated a healthy remodeling of the airway [11].

Baicalein reduced lung inflammation by inhibiting Th17 cells in the lungs [12].

6) Eyes

Daily intake of baicalin or baicalein helped prevent eye diseases such as cataracts or age-related macular degeneration in animals [13].

Baicalin is found in traditional Japanese herbal medicines for eye health [14].

7) Fertility

In animals, baicalin significantly enhanced endometrial reproduction [15].

In mouse embryos, it increased the development and quality of blastocysts [16].

Cancer Research

Baicalin and baicalein are currently under investigation in the following types of cancers:

  • Ovarian cancer [17]
  • Breast cancer [18]
  • Colorectal cancer [19, 20]

These experiments are currently limited to cell studies, however; such studies are often irrelevant for animal or human trials.

Baicalin ingested at a dose of 100 mg/kg for 28 days decreases tumor growth and replication in mice with colon cancer cells [21].

When taken orally in rats for 7 days it increases the activity of T helper cells and T regulatory cells to fight chemically-induced colon cancer [22].


There are a variety of limitations that should be kept in mind when reading this research.

  • Almost all of the studies conducted with baicalin are in animals, and it’s not clear if any of these benefits would occur in humans.
  • Flavonoids usually have poor bioavailability, and baicalin is no exception [23]. It’s unclear if any of these benefits would be seen in humans given the bioavailability issues. When given to animals, it’s often injected, which bypasses the bioavailability problem that humans would have.


There is no safe and effective dose of baicalin or baicalein because no sufficiently powered study has been conducted to find one.

Baicalein and baicalin supplements can be taken by healthy individuals. The healthy dose should be 200-800 mg in multiple doses, once in the morning and once again at night, without any side effects.

Buy Baicalin/Baicalein Supplement

About the Author

Joe Cohen, BS

Joe Cohen, BS

Joe Cohen flipped the script on conventional and alternative medicine…and it worked. Growing up, he suffered from inflammation, brain fog, fatigue, digestive problems, insomnia, anxiety, and other issues that were poorly understood in traditional healthcare. Frustrated by the lack of good information and tools, Joe decided to embark on a learning journey to decode his DNA and track his biomarkers in search of better health. Through this personalized approach, he discovered his genetic weaknesses and was able to optimize his health 10X better than he ever thought was possible. Based on his own health success, he went on to found SelfDecode, the world’s first direct-to-consumer DNA analyzer & precision health tool that utilizes AI-driven polygenic risk scoring to produce accurate insights and health recommendations. Today, SelfDecode has helped over 100,000 people understand how to get healthier using their DNA and labs.
Joe is a thriving entrepreneur, with a mission of empowering people to take advantage of the precision health revolution and uncover insights from their DNA and biomarkers so that we can all feel great all of the time.


1 Star2 Stars3 Stars4 Stars5 Stars
(5 votes, average: 4.20 out of 5)

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.

Leave a Reply

Your email address will not be published. Required fields are marked *

Related Articles View All