Evidence Based
4.1 /5
9

5 Health Benefits of Saw Palmetto

Written by Carlos Tello, PhD (Molecular Biology) | Last updated:
Jonathan Ritter
Puya Yazdi
Medically reviewed by
Jonathan Ritter, PharmD, PhD (Pharmacology), Puya Yazdi, MD | Written by Carlos Tello, PhD (Molecular Biology) | Last updated:

SelfHacked has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. We believe that the most accurate information is found directly in the scientific source.

We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic.

Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists.

All of our content is written by scientists and people with a strong science background.

Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again.

Our goal is to not have a single piece of inaccurate information on this website. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at [email protected]

Note that each number in parentheses [1, 2, 3, etc.] is a clickable link to peer-reviewed scientific studies. A plus sign next to the number “[1+, 2+, etc...]” means that the information is found within the full scientific study rather than the abstract.

Saw Palmetto

Saw palmetto is a very popular herbal supplement often used to improve symptoms of benign prostatic hyperplasia (BPH). Read on to see what the science says about this and other potential health benefits of saw palmetto.

What Is Saw Palmetto?

Saw palmetto is an extract of the berry of the saw palmetto tree (Serenoa repens) that is native to Southeast North America [1].

Saw palmetto has been used for centuries in Asia and North America for the treatment of benign prostatic hyperplasia (BPH), a non-cancerous enlargement of the prostate [2].

The Seminole tribe in Florida used the herb to treat urinary and sexual problems [2].

The plant gained recognition in the United States when it was listed as an official remedy in the US Pharmacopoeia in 1906. Since the 1990s it has been one of the top 10 most sold herbs in the U.S, with more than 2 million men using the herb regularly [3, 4].

In Europe, saw palmetto is the most popular herbal supplement used to treat BPH. Global sales of the herb total more than $700 million annually [3].

However, remember that saw palmetto is not FDA-approved for any conditions. You may try it if you and your doctor determine that it could be appropriate in your case. Saw palmetto should never be used in place of what your doctor recommends or prescribes.

Mechanisms Of Action

  • Saw palmetto inhibits 5-reductase, an enzyme that converts testosterone into dihydrotestosterone (DHT) [5].
  • Saw palmetto blocks 1-adrenoceptors [6, 7].
  • Saw palmetto reduces the activity of several inflammation-related genes [8].
  • Saw palmetto increases the production of p57 protein, a protein which decreases tumors [9, 10].
  • Saw palmetto decreases the production of p21 proteins, which advance tumor growth [9, 11].

Benefits Of Saw Palmetto

Possibly Effective for:

Urinary Tract Symptoms

Saw palmetto may treat lower urinary tract symptoms (LUTS). LUTS is a range of symptoms that include [12]:

  • Painful urination
  • Increased frequency of urination
  • Incomplete bladder emptying
  • Weak stream
  • Excessive nighttime urination

In 4 trials on over 400 men with LUTS, saw palmetto given over 12-24 weeks was more effective in improving symptoms than placebo [13, 14, 15, 16].

A study in 225 patients showed that 12 months supplementation with saw palmetto along with lycopene, selenium, and a drug commonly used to treat BPH symptoms (tamsulosin) was effective in the treatment of LUTS. The same combination was as effective as another drug (tadalafil) in a clinical trial on over 400 men with LUST due to BPH [17, 18].

The fixed combination of 160 mg saw palmetto fruit extract and 120 mg nettle root extract was also effective in 2 clinical trials on almost 400 men with LUST due to BPH [19, 20].

However, another trial on 369 men with LUTS aged 45 years and older found that saw palmetto extract given over 72 weeks was no more effective than placebo [21].

Excessive urination during the night (nocturia) can cause insomnia and sleep deprivation, which decreases productivity and quality of life [22].

Saw palmetto extract (both alone and combined with nettle root) significantly decreased the number of nighttime urinations compared to a placebo and two other drugs used to treat excessive nighttime urination in 2 clinical trials on over 1,000 men with LUTS [23, 24].

Insufficient Evidence for:

1) Benign Prostatic Hyperplasia

Benign prostatic hyperplasia (BPH) is a growth of the prostate that is not due to cancer. It is very common in older men: nearly 40% of American men over the age of 60 and 90% of men over 80 have BPH [25, 26].

Research on saw palmetto’s ability to treat BPH is conflicting. In a study in 82 men aged 30 years and older, saw palmetto decreased symptoms of BPH [1, 27].

However, another trial on 100 men aged 45 and older found no difference in treating BPH after 72 weeks of saw palmetto [28].

Similarly, a study of over 2,000 men found that 72 weeks of saw palmetto was no more effective than a placebo in the treatment of BPH [29].

Finasteride (Propecia) is a prescription 5-reductase inhibitor that is commonly used to treat BPH. A year-long study on over 1,000 men found that saw palmetto was more effective than finasteride in treating excessive nighttime urination. It was, however, less effective in treating other symptoms related to BPH [30].

A 2002 Cochrane review concluded that saw palmetto was effective in treating BPH. However, a 2009 Cochrane review that included larger and longer trials found that saw palmetto had no effect on BPH [31, 32].

A 2016 review only included trials with a special standardized extract of saw palmetto called Permixon. Permixon was effective in improving urinary symptoms of BPH compared to placebo. It was just as effective as finasteride in treating BPH [33].

This suggests that the lack of an effect found in the most recent Cochrane review was due to the differences in the saw palmetto extracts used.

All in all, the evidence is insufficient to determine if saw palmetto is effective for this condition due to the mixed results. Further clinical trials are needed to shed some light on this potential benefit of saw palmetto.

2) Male-Pattern Baldness

Saw palmetto is commonly used to treat hair loss caused by male-pattern baldness (androgenic alopecia). Male-pattern baldness is the loss of hair in men due to genetics and too much dihydrotestosterone [34].

Testosterone is converted into dihydrotestosterone (DHT) by the 5-reductase enzyme. Saw palmetto blocks this enzyme, which decreases DHT and may increase hair growth [5, 35].

A study with 50 men with male-pattern baldness found that saw palmetto taken daily for two years increased hair growth on the top (crown) of the head [36].

A case report found that a 24-year-old woman with pattern hair loss responded to treatment with saw palmetto [34].

One study found that topical saw palmetto products were able to increase hair growth in 50 men with male-pattern baldness [37].

Although the results are promising, only 2 clinical trials support the use of saw palmetto to treat male-pattern baldness. Larger, more robust clinical trials are needed to confirm these preliminary findings.

3) Boosting Testosterone

By decreasing the conversion of testosterone to DHT, saw palmetto may increase testosterone levels.

For instance, one study saw a significant increase in testosterone after three months of 320 mg saw palmetto in prostate tissue isolated from 25 patients with BPH [38].

A clinical trial on 32 men found that 80 mg saw palmetto extract twice a day for six days increased testosterone levels compared to placebo. However, there is some risk of bias because the study was not blinded [39].

Two small clinical trials (one of them with a high risk of bias) cannot be considered conclusive evidence that saw palmetto helps boost testosterone. Further clinical research is required.

4) Improving Quality of Life

Quality of life is a measure of physical, social, and emotional well-being.

Supplementation with 320 mg saw palmetto daily for 8 weeks significantly increased quality of life scores by 42% in a pilot trial in 82 men [27].

A single clinical trial evaluating subjective parameters is clearly insufficient to claim that saw palmetto improves quality of life. More clinical trials on larger populations are warranted.

Possibly Ineffective for:

Reducing the Risk of Prostate Cancer

In a cell-based study, saw palmetto berry extract prevented prostate cancer growth by increasing p53 protein production [9].

Another study found that blocking 5-reductase saw palmetto extract was able to decrease the growth of prostate cancer cells [40].

However, a long-term study on over 35,000 men found no association between the consumption of saw palmetto and the risk of developing prostate cancer [41].

Sexual Function

Saw palmetto has traditionally been used to treat erectile dysfunction and improve sexual function [2].

A pilot trial showed a significant increase in sexual function in 82 men aged 30 and older. However, it’s important to note that the study was funded by the manufacturer of the saw palmetto extract employed (Prostasan) [27].

Another study on 369 men found no significant difference between saw palmetto and a placebo in treating sexual dysfunctions [21].

Side Effects and Precautions

This list does not cover all possible side effects. Contact your doctor or pharmacist if you notice any other side effects.

Call your doctor for medical advice about side effects. In the US, you may report side effects to the FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada, you may report side effects to Health Canada at 1-866-234-2345.

A systematic review assessed human safety data of saw palmetto and found that side effects are mild and similar to those with placebo [42].

According to the review, the most frequently reported side effects were: [42]

  • Stomach pain
  • Diarrhea
  • Nausea
  • Fatigue
  • Headaches
  • Decreased sex drive
  • Nasal Inflammation

More serious adverse events like death and brain hemorrhage were reported in isolated incidents, but their link with saw palmetto is highly questionable [42].

There have been two cases of pancreatic inflammation in individuals using saw palmetto [43].

In 2 patients, saw palmetto caused liver inflammation and acute liver damage [44, 45].

Due to the lack of safety data, saw palmetto should not be used in women who are pregnant or breastfeeding [2, 46].

Drug Interactions

Supplement/Herb/Nutrient-drug interactions can be dangerous and, in rare cases, even life-threatening. Always consult your doctor before supplementing and let them know about all drugs and supplements you are using or considering.

Drugs That Reduce Clotting

One patient taking saw palmetto extract experienced significantly more blood loss than normal during surgery and reduced clotting of their blood (bleeding time). The patient’s clotting ability returned to normal after stopping treatment with the extract [47].

Because of this, saw palmetto should not be taken by drugs that reduce clotting. These include:

  • Aspirin
  • Warfarin (Coumadin)
  • Apixaban (Eliquis)
  • Rivaroxaban (Xarelto)
  • Clopidogrel (Plavix)
  • Ibuprofen and other NSAIDs

Birth Control

Saw Palmetto may reduce the effectiveness of birth control pills by lowering estrogen levels [48]

5-reductase Inhibitors

Because saw palmetto inhibits DHT conversion it should not be used with prescription DHT blockers like finasteride (Propecia).

Saw Palmetto In Combination With Other Treatments

1) Nettle Root

The combination of extracts from saw palmetto fruit and nettle root was similar to finasteride and tamsulosin in improving urinary symptoms in patients with BPH [49, 19].

2) Astaxanthin

A combination of saw palmetto extract and astaxanthin increased testosterone levels and decreased dihydrotestosterone and estradiol levels [50].

Astaxanthin combined with saw palmetto extract was more effective in stopping the growth of cancer cells than saw palmetto extract alone [40].

3) Pumpkin Seed Oil

A study found that a combination of saw palmetto and pumpkin seed oil greatly improved symptoms of BPH and quality of life, and decreased prostate specific antigen (PSA) levels [51].

Individual Experiences With Saw Palmetto

The opinions expressed in this section are solely those of saw palmetto users, who may or may not have medical or scientific training. Their reviews do not represent the opinions of SelfHacked. SelfHacked does not endorse any specific product, service, or treatment.

Do not consider user experiences as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare providers because of something you have read on SelfHacked. We understand that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.

One user reported noting a dramatic decrease in hair loss after using saw palmetto.

Another user found it was much easier to pass urine. He stated that “before, it stopped, start, stop, start, and now there is a steady flow of urine every time I go. However, I am still getting up 2 or 3 times during the night to pass urine”.

One user took saw palmetto for 16 years and claimed that it helped improve stream size and decreased urgency to urinate.

Some people have experienced negative effects from the herb. After using it for a few months, one user got very sick, “like hitting strong flu”.

Buy Saw Palmetto Supplement

This section contains sponsored links, which means that we may receive a small percentage of profit from your purchase, while the price remains the same to you. The proceeds from your purchase support our research and work. Thank you for your support.

About the Author

Carlos Tello

Carlos Tello

PhD (Molecular Biology)
Carlos received his PhD and MS from the Universidad de Sevilla.
Carlos spent 9 years in the laboratory investigating mineral transport in plants. He then started working as a freelancer, mainly in science writing, editing, and consulting. Carlos is passionate about learning the mechanisms behind biological processes and communicating science to both academic and non-academic audiences. He strongly believes that scientific literacy is crucial to maintain a healthy lifestyle and avoid falling for scams.

Click here to subscribe

RATE THIS ARTICLE

1 Star2 Stars3 Stars4 Stars5 Stars
(24 votes, average: 4.13 out of 5)
Loading...

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.