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Creatine Nitrate: Benefits, Side Effects, Dosage, Reviews

Written by Puya Yazdi, MD | Last updated:
Medically reviewed by
Genius Labs Science Team | Written by Puya Yazdi, MD | Last updated:

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Creatine nitrate blends the benefits of dietary creatine and nitrates. Its proponents believe that it enhances exercise performance by increasing endurance, muscle mass gain, and fatigue resistance. Does it work? Read on to learn more.

What Is Creatine Nitrate?

Creatine nitrate is a synthetic formulation of creatine monohydrate, a widely used dietary supplement. It is made by combining nitric acid and creatine in water [1].

According to its proponents, creatine nitrate combines the beneficial effects of creatine and nitrate supplementation. Numerous studies report the improvements in exercise performance from both molecules [2].

As the use of creatine nitrate becomes more popular, more studies are required to validate its beneficial effects on physical performance [3].

Creatine Nitrate vs. Creatine Monohydrate

The nitrate in creatine nitrate may mean that it’s more water-soluble than creatine monohydrate. This may also increase the amount of creatine the muscles take up by relaxing blood vessels, according to a patent filed by Thermolife International [4].

Both forms of supplements are typically used to increase the rate of muscle mass gain, and they are well-tolerated [2].

Components

Creatine

Creatine is a naturally occurring amino acid made in the liver, kidneys, and pancreas. It is also obtained through a diet that includes red meat and fish [5, 6].

The body uses creatine to provide a longer-lasting supply of energy to the muscles during exercise [3].

Since the 1990s, creatine has been popularly used by athletes and bodybuilders as a dietary supplement. Many studies have investigated the benefits and safety of creatine [5, 7].

Nitrate

Nitrates are inorganic salts present in most vegetables, fruits, and grains [8].

Dietary nitrate is associated with exercise endurance and heart health [9].

Benefits of Creatine Nitrate

Creatine supplements have not been approved by the FDA for medical use. Regulations set manufacturing standards for them but don’t guarantee that they’re safe or effective. Speak with your doctor before supplementing, and never use creatine nitrate to replace something your doctor recommends or prescribes.

Possibly Effective For

1) Athletic Performance

In a study (DB-RCT), 48 healthy and active men were either given a low or high creatine nitrate dose (1.5g, 3g), high dose of creatine monohydrate (3g), or placebo for 28 days. Participants who received a high dose of creatine nitrate could bench press a greater weight than participants who received the placebo, thus improving overall exercise performance [10].

In another study (DB-RCT) on 28 men and women, taking creatine nitrate for 6-days increased weight lifted in bench and leg press exercises. It also improved exercise performance and endurance [11].

2) Muscle Mass & Strength

A meta-analysis of 22 studies found that creatine supplementation increased lean tissue mass and muscle strength in older adults aged 57-70 years [12].

Creatine nitrate increased fat-free and lean mass after a 28-day consumption in a study (DB-RCT) on 48 healthy men [10].

Combination with Other Supplements

In a study (DB-RCT), 25 healthy and active participants received creatine nitrate in a pre-workout supplement of various compounds, such as beta-alanine, caffeine, and arginine alpha-ketoglutarate (AAKG) for 8-weeks. There was no improvement in exercise performance between the participants on placebo or the pre-workout supplement [13].

However, participants who took the pre-workout supplement were more optimistic and ready to work out than participants who took placebo [13].

Some researchers believe that creatine nitrate supplementation may have differing effects on different populations [5].

Creatine Nitrate Metabolism

Creatine nitrate is broken down into creatine and nitrate in the body, according to a patent filed by Thermolife International. Creatine and nitrate may achieve beneficial effects separately [4].

Creatine

Creatine is absorbed from the gut and then transported to the muscles via the bloodstream where transporter proteins (CreaT1) take up creatine molecules into the muscle [14].

The overall uptake of creatine into muscles depends on many factors, including total creatine content, hormones, and exercise. For example, less creatine will be taken up by the transporter proteins if the muscle has reached the maximum storage capacity [14, 15].

Creatine increases energy storage in muscles and improves endurance during prolonged physical exercise [16].

It also increases muscle mass by decreasing the levels of a protein that blocks muscle growth (myostatin) and increasing cells that boost muscle growth (satellite cells) [17, 18].

Creatine breaks down into creatinine and is flushed from the body through urine [6].

Nitrates

Nitrate ions do not benefit the body directly. Rather, researchers believe that nitric oxide, produced by the breakdown of nitrates, is responsible for the benefits of dietary nitrate supplementation [9].

Bacteria in the mouth convert nitrates to nitrites, which can then be broken down into nitric oxide or nitrosamines in the mouth or gut [19].

Nitric oxide is also made in tissues when oxygen levels are abnormally low. Increased concentrations of nitrites and nitric oxide in blood relax blood vessels and the heart, which leads to a decrease in blood pressure [20, 21, 22, 9].

Nitrate supplementation may improve muscle endurance during exercise by decreasing oxygen and energy demands per unit of force. It may also reduce energy demands, which indirectly amplifies the improvement of exercise performance [23, 22, 9].

Natural Sources and Supplementation

As a supplement, creatine nitrate is available in powder or capsule form.

Creatine

Creatine is mainly found in animal products, including [24]:

  • Red meat (Greatest concentration)
  • Fish
  • Poultry
  • Milk
  • Milk Products

Uncooked meats (chicken, beef, rabbit) contain approximately 3.4 g/kg creatine, which decreases when the meat is cooked [25].

Milk contains much less, approximately 0.7 g/kg of creatine [26].

Nitrates

Nitrates are mainly found in fruits and vegetables [27].

Very high nitrate levels (>2500 mg/100 g of fresh weight) are found in the following vegetables [28]:

  • Celery
  • Cress
  • Chervil
  • Lettuce
  • Red beetroot
  • Spinach
  • Arugula

Supplementation

Safety and Side Effects

Two studies (including 1 DB-RCT and 1 RCT of 48 and 58 participants, respectively) have shown that consuming creatine nitrate at a daily dose of 1-3g for 28 days was safe and well-tolerated [10, 29].

Side effects were rarely reported and are not serious. They included [2]:

  • Dizziness
  • Headaches
  • Faster heartbeat
  • Heart skipping/palpitations
  • Nervousness
  • Blurred vision

Potential Risks

Nitrites formed from creatine nitrate might react with dietary amines from proteins to form cancer-causing nitrosamines [30].

Natural sources of nitrates contain vitamin C and other antioxidants that block the formation of nitrosamines. When taking creatine nitrate, a lack of antioxidants may increase the risk of nitrosamine formation [30].

In cells, creatine reacted with nitrites in acidic conditions to form a cancer-causing compound called N-nitrososarcosine, NSAR [31].

Creatine nitrate may contain harmful contaminants such as melamine and chemicals that disturb hormonal systems [32].

Multiple case reports studies (case reports) have reported that excess creatine intake caused kidney damage [33, 34, 35, 36].

Limitations and Caveats

Creatine nitrate is a new addition to the creatine supplement family, and it has not been researched as extensively as other creatine forms.

The potential effects on the body of an interaction between high concentrations of creatine and nitrate need to be examined as they may react to form cancer-causing compounds [30, 31].

The long-term safety of creatine nitrate use and its safety in children and adolescents has not been established.

Drug Interactions

No drug interactions have been reported thus far for creatine nitrate. However, creatine produced by taking this supplement may interact with:

Caffeine

Creatine and caffeine have been shown to improve exercise performance and are frequently used in combination [37].

Simultaneous caffeine intake eliminated the performance-enhancing effects of creatine in a study on 9 healthy participants [38].

In a study (DB-RCT) on 10 healthy participants, consuming caffeine and creatine had opposite effects on muscle relaxation times. Creatine shortened the muscle relaxation time, whereas caffeine prolonged it. Thus, taking caffeine with creatine may cancel out the beneficial effects of creatine on exercise performance [39].

To avoid adverse effects or unexpected interactions, talk to your doctor before taking creatine supplements.

Dosage

In clinical studies, a daily intake of 1-3 g of creatine nitrate was safe and did not cause any adverse effects [10, 29].

A dosage of 6g/day was safe in one study, but supplementation only lasted for six days at a time in this study, and additional studies are needed to confirm the long-term safety of this dosage [1].

User Experiences/Reviews

Users report noticeably increased muscle mass and gains with creatine nitrate use compared to creatine monohydrate, which is more commonly used.

Other users also experienced minimal water retention that sometimes accompanies creatine monohydrate use

Lastly, users reported minimal/no side effects with creatine nitrate use.

About the Author

Puya Yazdi

Puya Yazdi

MD
Dr. Puya Yazdi is a physician-scientist with 14+ years of experience in clinical medicine, life sciences, biotechnology, and nutraceuticals.
As a physician-scientist with expertise in genomics, biotechnology, and nutraceuticals, he has made it his mission to bring precision medicine to the bedside and help transform healthcare in the 21st century.He received his undergraduate education at the University of California at Irvine, a Medical Doctorate from the University of Southern California, and was a Resident Physician at Stanford University. He then proceeded to serve as a Clinical Fellow of The California Institute of Regenerative Medicine at The University of California at Irvine, where he conducted research of stem cells, epigenetics, and genomics. He was also a Medical Director for Cyvex Nutrition before serving as president of Systomic Health, a biotechnology consulting agency, where he served as an expert on genomics and other high-throughput technologies. His previous clients include Allergan, Caladrius Biosciences, and Omega Protein. He has a history of peer-reviewed publications, intellectual property discoveries (patents, etc.), clinical trial design, and a thorough knowledge of the regulatory landscape in biotechnology.He is leading our entire scientific and medical team in order to ensure accuracy and scientific validity of our content and products.

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