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High & Low Eosinophil Count + Function & Diseases

Written by Puya Yazdi, MD | Last updated:
Jonathan Ritter
Medically reviewed by
Jonathan Ritter, PharmD, PhD (Pharmacology) | Written by Puya Yazdi, MD | Last updated:

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Eosinophils are white blood cells that play a role in the immune response. They help fight infections, mainly by parasites, and are involved in allergies and inflammation. But when they get out of control, they may cause damage to the body.

Read on to learn more about eosinophils, their role in our health and disease.

What are Eosinophils?

Eosinophils are a special type of white blood cell. Like other blood cells, they are produced in the bone marrow [1].

They circulate in the blood for short periods of time. When activated, eosinophils move into the affected tissue and secrete inflammatory substances that help destroy the foreign organisms [1, 2, 3].

They are primarily known to help combat intestinal parasites, but their role in the immune system is much more complex [4].

Sometimes, when there are too many of them, eosinophils can also cause damage to tissues [1].

Function

Eosinophils help fight infections by releasing toxic substances that can kill pathogens and generate inflammation. They can also “devour” (phagocyte) bacteria [4, 5].

Eosinophils protect us against infections caused by:

  • Intestinal worms (helminths) and other parasites [6, 7]
  • Viruses [8, 9, 10]
  • Bacteria, [11, 12, 13]
  • Fungi [14]

Eosinophils also help protect against future infections by bacteria, viruses, and parasites by activating acquired immunity (acting as antigen-presenting cells) [15].

In addition, eosinophils can help keep the immune system balanced. They help control the response to foreign antigens (structures that antibodies bind to). These include food and microorganisms (harmful and beneficial, e.g. microbiota). Eosinophils also help prevent immune cells from attacking the body’s own tissues [2, 16, 17].

Finally, eosinophils increase inflammation, which is beneficial in some situations, but can be harmful in others. Eosinophils can activate mast cells, which are special cells that generate inflammation when activated [18].

Normal Range

The normal range of eosinophils is 0-0.5 x 10^9/L or less than 500 cells per microliter (mL) of blood [19].

This normally amounts to less than 5% of all your white blood cells.

Low Eosinophils

Eosinophils are normally low and can be as low as zero in healthy adults.

However, there are underlying conditions and medication that can suppress eosinophil levels.

Causes shown here are commonly associated with low eosinophils. Work with your doctor or another health care professional to get an accurate diagnosis.

Causes of Low Eosinophil Levels

1) Infections

When there is an acute infection, several substances are secreted to attract eosinophils from blood to affected tissues. This causes blood eosinophil levels to drop rapidly. A complete absence of eosinophils is also seen in serious infections such as sepsis [20, 21].

2) Cushing’s syndrome

Cushing’s syndrome occurs after a person is exposed to high cortisol levels for a long time, either due to an underlying health condition or long-term cortisol therapy. Cortisol suppresses the immune system and lowers eosinophil levels in the blood [22].

3) Drugs

Glucocorticoids are anti-inflammatory drugs related to cortisol. They diminish the production, survival, and function of eosinophils [23].

Some drugs, including glucocorticoids, used to suppress the immune system, and theophylline, used to prevent and treat wheezing, shortness of breath, and chest tightness caused by asthma, chronic bronchitis, and other lung diseases [24, 25].

High Eosinophils

An above-normal level of eosinophils is called eosinophilia. Depending on how high the blood levels are, it can be [26]:

  • Mild: 0.5 – 1.5 x 10^9/L (500 to 1,500 cells per microliter of blood)
  • Moderate: 1.5 – 5 x 10^9/L (1,500 to 5,000 cells per microliter of blood)
  • Severe: > 5 x 10^9/L (more than 5,000 cells per microliter of blood)

Eosinophilia in the blood or tissues can be harmful since eosinophils have granules containing toxic molecules that are meant to kill pathogens. The toxic molecules can also damage tissues when present in large quantities [7, 27].

Causes of High Eosinophil Levels

Causes shown below are commonly associated with high eosinophils. Work with your doctor or another health care professional to get an accurate diagnosis. Your doctor will interpret this test, taking into account your medical history and other test results, and will repeat it if necessary.

1) Allergies

Eosinophils increase in allergic diseases such as asthma and hay fever. They also increase when a person has an allergic response to medication [28, 29, 30, 31].

2) Eczema and Other Skin DIsease

Eczema and atopic dermatitis [28, 32, 33].

Eczema and other skin diseases: High levels of eosinophils are found in skin lesions in urticaria, contact dermatitis, eczema, and prurigo, but not always necessarily in the blood [34].

3) Infections

Infections from intestinal worms, parasites, fungi, and viruses often cause an elevation in eosinophil levels [28, 29].

4) Autoimmune Diseases

In several autoimmune diseases, including celiac disease, there are high eosinophil blood levels as a reflection of the inflammation present, but eosinophils do not necessarily contribute to the disease [28, 29, 35, 36].

5) Inflammatory Bowel Disease

Eosinophils can also increase in inflammatory bowel disease (IBD) — both in Crohn’s disease and ulcerative colitis [28, 37, 38, 39].

6) Vitamin D Deficiency

Vitamin D deficiency has been associated with a slight increase in eosinophils [40].

7) Addison’s Disease

Addison’s disease, in which there is a lack of adrenal hormones, such as cortisol, can increase eosinophil levels [28].

8) Cancer

In some forms of cancer, high levels of eosinophils appear as a consequence of cancer, as in Hodgkin’s lymphoma [41].

In other cases, eosinophils are the main cancerous cell, such as in acute and chronic eosinophilic leukemia [42].

  • T cell lymphoma [42]
  • Chronic myelomonocytic leukemia [42]

9) Hypereosinophilic Syndromes

Hypereosinophilic syndromes are a group of disorders in which eosinophils are persistently elevated [28].

For many of these symptoms there is no known cause, while some others can be genetic [43, 28].

Decreasing Eosinophils

The most important thing is to work with your doctor to find out what’s causing your high eosinophils and to treat any underlying conditions. The additional lifestyle changes listed below are other things you may want to discuss with your doctor. None of these strategies should ever be done in place of what your doctor recommends or prescribes!

People who have persistent but benign high eosinophil levels do not need to undergo treatment to decrease their levels. However, periodical check-ups are advised [7].

Check your vitamin D levels. Vitamin D deficiency has been associated with slightly increased eosinophil counts [40].

If your eosinophilia is caused by certain drugs, you should talk to your doctor and see if you there are any alternatives available [28].

Initial studies suggest that a supplement, Boswellia serrata, may help decrease elevated eosinophil levels and inflammation in asthma [44, 45].

Remember, always speak to your doctor before taking any supplements, because they may interfere with your treatment!

Genes Related to Eosinophil Levels

These variants have been associated with eosinophil levels in the blood:

  • rs1129844 SNP in the eotaxin-1 gene (CCL11) [46]
  • rs2302009 SNP in the eotaxin-3 gene (CCL26) [47]

However, the reports are from studies that focused on people with asthma. More studies are needed to check if the same association is found in the general population.

Apart from single point mutations, there are larger abnormalities in chromosomes that can disrupt genes or merge them with others (fusion genes). Some of such abnormalities have been reported to increase blood eosinophil levels. Disrupted or altered genes include:

About the Author

Puya Yazdi

Puya Yazdi

MD
Dr. Puya Yazdi is a physician-scientist with 14+ years of experience in clinical medicine, life sciences, biotechnology, and nutraceuticals.
As a physician-scientist with expertise in genomics, biotechnology, and nutraceuticals, he has made it his mission to bring precision medicine to the bedside and help transform healthcare in the 21st century.He received his undergraduate education at the University of California at Irvine, a Medical Doctorate from the University of Southern California, and was a Resident Physician at Stanford University. He then proceeded to serve as a Clinical Fellow of The California Institute of Regenerative Medicine at The University of California at Irvine, where he conducted research of stem cells, epigenetics, and genomics. He was also a Medical Director for Cyvex Nutrition before serving as president of Systomic Health, a biotechnology consulting agency, where he served as an expert on genomics and other high-throughput technologies. His previous clients include Allergan, Caladrius Biosciences, and Omega Protein. He has a history of peer-reviewed publications, intellectual property discoveries (patents, etc.), clinical trial design, and a thorough knowledge of the regulatory landscape in biotechnology.He is leading our entire scientific and medical team in order to ensure accuracy and scientific validity of our content and products.

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