Glucuronidation is an important detoxification reaction that inactivates and detoxifies estrogens, hormones, neurotransmitters, drugs, mold toxins, and cancer-causing toxins. In this post, we’ll explain glucuronidation and factors that increase or decrease it. In addition, we’ll also cover beta-glucuronidase, an enzyme produced by gut bacteria that undoes glucuronidation. Finally, we’ll review the genes that affect glucuronidation.
Glucuronidation involves the addition of glucuronic acid to a toxic molecule to make it :
If toxins don’t get properly inactivated and removed, they cause cell and tissue damage and may initiate cancer.
Glucuronidation is one of the most important detox reactions taking place in our bodies .
It is responsible for the clearance of many drugs, cancer-causing chemicals, environmental toxins, and substances found in food .
Glucuronidation enzymes (UGTs) are found throughout the body: in the gut, kidney, brain, pancreas, and placenta. However, the majority are found in the liver .
In the brain, UGTs actively protect against the intrusion of harmful chemicals .
Enzymes responsible for glucuronidation are called UDP-glucuronosyltransferases or UGTs .
In humans, around 40 – 70% of all clinical drugs are cleared by UGTs .
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