Hordenine is found in some everyday foods such as barley and the bitter orange. Beer brewed from barley may even increase levels of hordenine in the blood.
Its effects range from increasing energy and focus to protecting the skin. However, taking too much hordenine may cause false positives in drug tests and produce a variety of negative side effects.
What is Hordenine?
Hordenine, otherwise known as N, N-dimethyltyramine, is an alkaloid mainly found in plants such as barley that are used as feed for animals [R].
It is adrenergic, meaning it causes nerve cells to release the neurotransmitters epinephrine (adrenaline) and norepinephrine (noradrenaline). Molecules like epinephrine and norepinephrine increase energy and focus and are part of the “fight-or-flight” response [R, R, R].
There used to be scandals with racing horses that were given food containing hordenine in order to improve performance. However, in most countries, the slight increase in performance caused by hordenine was deemed insufficient to be considered cheating [R].
This is mainly because hordenine’s effects are short-lived and a very high concentration of hordenine is needed to bring about any noticeable effect [R].
In Canada, however, it is considered illegal and horses are not allowed to eat hordenine-rich diets [R].
Hordenine can be used to measure beer consumption, as hordenine levels in the blood increase significantly following consumption. Forensic toxicology reports can use hordenine as a suitable measure for beer consumption [R].
Food Sources of Hordenine
Health Benefits of Hordenine
1) Hordenine May Increase Alertness
Horses injected with hordenine (intravenously) showed increased alertness within two minutes. A 100% increase in heart and breathing rate accompanied the increased alertness [R].
However, the effect only lasted 20 minutes. When hordenine was given orally, alertness did not increase [R].
Some side effects included profuse sweating and defecation immediately after [R].
2) Hordenine May Increase Energy
3) Hordenine May Protect the Skin
Therefore, molecules that can decrease melanin production without side-effects are needed. Hordenine decreased melanin production in human cells by 30% [R].
Limitations of Hordenine
1) Hordenine May Cause False-Positives in Drug Testing
The opioid tests that hordenine can affect are [R]:
The biggest cause of hordenine increase in humans is through beer brewed from barley. People who need to take certain opioid drug tests are advised to drink barley-brewed beer in moderation [R].
2) Limited Clinical Testing of Hordenine
There are no clinical tests on hordenine yet, so it is difficult to predict how hordenine would affect humans. More extensive testing is necessary to fully validate many of hordenine’s effects.
Side Effects of Hordenine
1) Hordenine May Reduce the Breakdown of Other Neurotransmitters
Monoamine oxidase-B (MAO-B) inactivates hordenine. MAO-B is responsible for inactivating other neurotransmitters such as dopamine and phenylethylamine. When MAO-B is busy breaking down hordenine, it may cause other neurotransmitters to build up [R, R].
2) Hordenine May Cause Fluctuations In Blood Pressure
In cats, hordenine initially decreased blood pressure, but this decrease was followed by a large spike in blood pressure. Afterwards, the blood pressure decreased again to a larger degree, only to recover once again [R].
People sensitive to blood pressure changes should not take too much hordenine.
3) Hordenine May Cause Convulsions
Hordenine increased convulsions (measured by knee jerks) in cats [R].
It is a cholinesterase inhibitor, meaning it keeps the enzyme cholinesterase from breaking down acetylcholine. Acetylcholine carries the signals from your nerve cells to cause things like movement. By blocking cholinesterase from breaking down acetylcholine, your body would naturally not stop moving and may keep convulsing [R].
4) Hordenine May Decrease Protection from UV Radiation
Melanin protects human skin by absorbing free radicals and preventing UV damage. Because hordenine decreases melanin production, it can increase UV damage. In individuals not suffering from overproduction of melanin (hyperpigmentation), hordenine may do more harm than good [R].
5) Continuous Hordenine Consumption May Damage Kidneys
Voles fed high doses of hordenine-containing foods developed damage in their kidneys (in the proximal tubules). Tubular hydropic degeneration, which is damage done to the kidney cells due to overfilling with water, occurred in the voles fed the highest concentration of hordenine [R].
Due to the lack of hordenine studies on humans, it is difficult to pinpoint a recommended dosage. A hordenine capsule supplement recommends taking one capsule of hordenine (50mg) with each meal [R].
One study gave cats 5mg/kg of hordenine claiming that the low dosage was the threshold to see any effect. The study mentioned that 10-30mg/kg of hordenine is a big dose. Although this dose may translate over to humans, it is a very rough estimate. Ask a doctor to see how much hordenine is right for you [R].
Synergies with Other Supplements
PEA is also broken down by monoamine oxidase-B (MAO-B), so PEA and hordenine compete in getting broken down [R].
When combining both supplements, it is advised to take lower than recommended doses of both supplements, as over stimulating the adrenergic system may produce adverse effects.
Hordenine User Reviews
There are not many reviews out for hordenine as its usage as a supplement is limited and there are not many hordenine supplements out for sale. One reviewer did say that the hordenine supplement provided them with energy throughout the day and gave the supplement a glowing review [R, R].
One user noted that it provides “serious stimulation” and increases well-being and pleasure without being addictive. He strongly recommends the supplement [R].