Acetylcholine is a hot topic within the realm of memory enhancement. It is a neurotransmitter that is critical for the everyday functioning of the brain, particularly in the areas of movement, learning & memory, and sleep quality. Check out this post to learn how to promote balanced acetylcholine in your body and function at your very best.
- Benefits of Acetylcholine
- Cons of Acetylcholine
- How to Change Your Levels of Acetylcholine
Acetylcholine is a neurotransmitter that is used for many things: from stimulating muscles to memory and sleep.
Acetylcholine is synthesized in nerve terminals from acetyl-CoA (which is synthesized from glucose) and choline in a reaction that is catalyzed by choline acetyltransferase [R].
Acetylcholine controls movements by activating skeletal muscles and causes muscle contraction [R].
It also schedules and promotes REM sleep [R].
Benefits of Acetylcholine
1) Acetylcholine Prevents Memory Loss
Too little acetylcholine in the hippocampus has been associated with dementia and Alzheimer’s [R].
Acetylcholine may enhance memory by helping encoding new memories and increasing the modification of synapses [R].
2) Acetylcholine Improves Attention
Acetylcholine helped improve attention and improves decision-making skills [R].
3) Acetylcholine Helps You Sleep Better
4) Acetylcholine Regulates Gastrointestinal Activity
Presynaptic nicotinic acetylcholine receptors (nAChRs) help release acetylcholine in the gut.
These receptors mediate a positive feedback with respect to ACh release from motor neurons, and therefore plays an important role in the regulation of gut flow [R].
5) Acetylcholine Protects Against Infections
Acetylcholine can modulate inflammatory responses. Acetylcholine was shown to have the ability to inhibit biofilm formation during a fungal infection (Candida albicans). Also, it inhibited inflammation-induced damage to internal organs [R].
6) Acetylcholine Affects Hormone Secretion
Cons of Acetylcholine
Acetylcholine is Related to Myasthenia Gravis
In myasthenia gravis, antibodies either block, alter, or destroy the receptors for acetylcholine at the neuromuscular junction, preventing muscle contractions.
It is a defect in the transmission of nerve impulses to muscles. However, it is unclear if antibodies against receptors in the brain can directly cause the disease [R].
How to Change Your Levels of Acetylcholine
When it comes to the herbs listed, they increase acetylcholine by inhibiting the enzyme that breaks them down – acetylcholinesterase. Most common herbs have some inhibitory activity against the enzyme.
- Foods with Choline (Eggs, Liver)
- Choline supplements
- Bacopa (R)
- Huperzine A
- Epimedium (R),
- Caffeine (R),
- Blueberries (R),
- Zinc (R),
- Copper (R),
- Grape seed Extract (R),
- Cinnamon (R),
- Tulsi (R),
- Gotu Kola (R),
- EGCG [R].
- Curcumin [R].
- Manganese, in the presences of citrate, increases acetylcholine synthesis [R].
- DHA and dietary fish oils [R].
- Luteolin enhances choline, which in turn increases acetylcholine in the body [R].
- Quercetin (high dose) (R),
- Fo-ti (R),
- Saffron (R)
- Reishi (R),
- Carvacrol (R),
- Rhodiola (R),
- Rehmannia (R)/Catalpol (R)
- Noni (R),
- Schisandra (R),
- Magnesium (potentiates) (R),
- Andrographis (weak) (R),
- Fenugreek (R),
- Melatonin (R),
- Ginger (R),
- Danshen (R),
- Licorice (R),
- Sulforaphane (R),
- Ginseng (R),
- Propolis (R),
- Muira (R),
- Insulin (R),
- Fasting (R),
A lot of drugs can inhibit acetylcholine, either by imitating it or inhibiting choline [R].
- Lipoic Acid (in certain situations)
- Glycine in certain situations (R),
- Mercury compounds
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