Evidence Based
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Etizolam, Reviews, Sleep Effects, Uses & Warnings

Written by Helen Quach, BS (Biochemistry) | Last updated:
Jonathan Ritter
Medically reviewed by
Jonathan Ritter, PharmD, PhD (Pharmacology) | Written by Helen Quach, BS (Biochemistry) | Last updated:

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Etizolam is a benzodiazepine-like drug that helps treat anxiety and panic disorders. While it can help treat other diseases, it is also illegal in many countries. Read more below to learn about the pros and cons of this drug.

Disclaimer: By writing this post, we are not recommending this drug. Some of our readers who were already taking the drug requested that we commission a post on it, and we are simply providing information that is available in the scientific and clinical literature. Please discuss your medications with your doctor. Etizolam is specifically a drug that we at SelfHacked would recommend against, especially without consulting with a physician, since it is addictive.

What is Etizolam?

Etizolam is commonly used for a short term treatment for anxiety and panic disorders. While it is effective at treating certain disorders, it has also been a drug that has the potential for abuse.

Uses of Etizolam

1) Anxiety

In a double-blind study, etizolam is effective at treating anxiety and depressive symptoms [1, 2].

It reduces anxiety and shows signs as an antidepressant [3].

In a double-blind study with 30 female subjects, etizolam was effective at reducing anxiety and depressive activity.

When paired with other treatments, it alleviates symptoms in a case of panic disorder [4].

It is also an effective treatment for hypertension [5].

2) Pain

Etizolam can alleviate pain for up to thirty minutes but is not the ideal form of treatment [6].

In young female patients, etizolam in combination with a non-steroidal anti-inflammatory drug was an effective treatment for tension-type headaches [7].

This drug is also effective in treating irritable colon syndrome with concurrent chronic anxiety conditions [8].

3) Schizophrenic Delusions

Etizolam impacts P300 latency (decreased cognitive function in decision making) [9].

When it comes to cognitive function with those have anxiety disorders, doses of the drug were no more significant than the placebo [10].

Etizolam mitigates auditory delusion seen in a schizophrenic patient [11, 12].

4) Vertigo

Low doses reduce dizziness scores, functional and emotional scores in patients with benign paroxysmal positional vertigo [13].

5) Brain Disorders

Neuroleptic Malignant Syndrome is a brain disorder that can cause muscular dysfunction, unstable blood pressure levels, high fever, etc.

With the withdrawal of oral Etizolam, symptoms of Postoperative neuroleptic malignant syndrome was present in an elderly man who had undergone a lobectomy of the lung [14].

In a Parkinson’s patient, withdrawal of the drug induces symptoms of neuroleptic malignant syndrome [15].

Treatment can also reduce the recurrence of chronic subdural hematoma, which happens when blood pools in the brain [16].

Warnings and Cautions

In the few clinical studies that have been done with etizolam, it was well tolerated and produced few side effects [17].

However, there have been several cases of toxicity and it is addictive. Therefore, etizolam should be used with extreme caution, and only under a doctor’s guidance [17].

Although it has lower possibilities of dependence than conventional benzodiazepines, it should again be taken with caution because the possibility of dependence is not eliminated only mitigated [18].

Etizolam has sedative and sleep-inducing effects [19].

In contrast to adults, when children take etizolam they experience excitation and muscle weakness [20].

Genetics Related to Etizolam

CYP2C19

The CYP2C19 gene creates a protein that metabolizes etizolam. Specific genetic variants (AG and AA genotypes) for the single nucleotide polymorphism (SNP) rs4244285 are poor metabolizers of etizolam. This mutation is also referred to as CYP2C19*2 [21].

Want Better Ways to Improve Your Mood?

If you’re interested in natural and more targeted ways of improving your mood, we at SelfHacked recommend checking out this mood wellness report. It gives genetic-based diet, lifestyle and supplement tips that can help improve your mood. The recommendations are personalized based on your genes.

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About the Author

Helen Quach

BS (Biochemistry)

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