Evidence Based

High Anti-CCP? Natural ways to Reduce Inflammation

Written by Will Hunter, BA (Psychology) | Last updated:
Nicole Craven
Puya Yazdi
Medically reviewed by
Nicole Craven, MD, Puya Yazdi, MD | Written by Will Hunter, BA (Psychology) | Last updated:

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Anti-CCP antibody Test

High anti-ccp is usually a sign of inflammation. The following approaches are experimental and need more research, but here are some promising methods to potentially reduce inflammation.

It is important to remember that levels of the antibody are not directly linked to disease activity, but since anti-CCP antibodies are still believed to play a role in the destruction of the joints, some studies use them to try and understand or decipher substances that might affect disease progression [1].

Potential Natural Factors That May Decrease Inflammation in Joint Disease

1) Vitamin D

Vitamin D deficiency is linked to both a greater risk of developing rheumatoid arthritis and more severe arthritis symptoms such as pain, swelling and inflammation in existing patients [2, 3].

In a study of over 200 people, lower vitamin D levels were linked to higher anti-CCP antibody levels [4].

Vitamin D may help lower anti-CCP antibodies by suppressing overactive immune cells that attack the body’s own proteins and tissues [4].

Vitamin D deficiency is linked to both a greater risk of developing rheumatoid arthritis and is associated with higher anti-CCP antibodies.

2) Omega 3s

In case studies, higher omega-3 fatty acid levels are associated with a lower risk of anti-CCP antibody production [5, 6].

Omega-3 fats help by reducing inflammation that can increase the citrullination of proteins leading to an immune system reaction and increased anti-CCP [7, 8].

Studies show that in anti-CCP positive patients, higher levels of Omegas have the potential to lower the progression of inflammatory arthritis symptoms, but further study is needed [7, 9].

Omega 3’s are a promising strategy to reduce inflammation in people with high anti-CCP, but more studies are needed.

3) Wormwood

One study of 127 rheumatoid arthritis patients looked at the effect of taking sweet wormwood (Artemisia annua) or a placebo in addition to standard immunosuppressive drugs. Those given wormwood saw a nearly 10% greater reduction in anti-CCP antibodies and a greater reduction in painful and swollen joints after 48 weeks [10].

4) Address Gum Disease

Gum disease (periodontal disease) is often caused by an infection by the bacteria P. gingivalis [11].

Several studies have found that rheumatoid arthritis patients are more likely to have gum disease as well as more severe forms of the disease [12, 13, 14, 15, 16].

Some research suggests that oral bacteria such as P. gingivalis directly contribute to the development of rheumatoid arthritis [17].

Higher levels of antibodies to P. gingivalis are linked to higher levels of citrulline [11].

Dental treatment that removes P. gingivalis reduces the production of citrulline in RA patients [11].

Make sure to address any underlying gum disease and maintain good dental hygiene if you have rheumatoid arthritis and high anti-CCP levels.

5) Quit Smoking

Smoking increases the risk of testing positive for anti-CCP antibody levels and is also associated with higher levels and more severe disease status in Rheumatoid Arthritis patients [18, 19, 20, 21].

Smoking increases the citrullination of proteins that can trigger an autoimmune reaction [22].

Quitting smoking may help reduce inflammation in people with rheumatoid arthritis and high anti-CCP levels.

Irregular Anti-CCP Levels?

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About the Author

Will Hunter

Will Hunter

BA (Psychology)
Will received his BA in Psychology from the University of California, Los Angeles. 
Will's main passion is learning how to optimize physical and mental performance through diet, supplement, and lifestyle interventions. He focuses on systems thinking to leverage technology and information and help you get the most out of your body and brain.

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