Evidence Based
4.6 /5
2

Top 17 Benefits of tACS + Health Risks

Written by Carlos Tello, PhD (Molecular Biology) | Last updated:
Puya Yazdi
Medically reviewed by
Puya Yazdi, MD | Written by Carlos Tello, PhD (Molecular Biology) | Last updated:

SelfHacked has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. We believe that the most accurate information is found directly in the scientific source.

We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic.

Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists.

All of our content is written by scientists and people with a strong science background.

Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again.

Our goal is to not have a single piece of inaccurate information on this website. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at [email protected]

Note that each number in parentheses [1, 2, 3, etc.] is a clickable link to peer-reviewed scientific studies. A plus sign next to the number “[1+, 2+, etc...]” means that the information is found within the full scientific study rather than the abstract.

tACS

tACS, transcranial alternating current stimulation, involves using two or more electrodes to send sinusoidal waveforms of electricity onto certain positions of the skull in the hopes that it will change brain function. Some frequencies may need to be combined to get the right effects. Read this post to learn more about the potential benefits and drawbacks of tACS.

tACS Brain Stimulation

EEGs (electroencephalography; brain voltage readers) commonly use a Fourier Transformation to convert linear-time sequences of voltage changes in the brain to the domain of frequencies. This is where we get alpha (8-12.5 Hz) for drowsiness, beta (12.5-30 Hz) for alertness, theta (4-7 Hz) for early NREM sleep, and delta (0.1-3 Hz) for deep NREM sleep.

While theta and delta brainwaves are increased by alcohol, beta brainwaves can be increased with LSD, mescaline, and psilocybin [1, 2].

In the human brain, there are frequency bands that correspond to ultradian rhythm, a cycle of states of consciousness each with dominant brainwaves. The brainwaves cycle from rest to rest every 100 minutes (with activity between) and from wakefulness to wakefulness every three to eight hours (with drowsiness between) [3].

Recording and analyzing our own brain signals has the potential to help us schedule our work life on cycles of states of consciousness. This may allow us to work harder in wakeful activity states and take short breaks in resting states and long breaks in resting drowsy states.

Snapshot

Proponents

  • May improve memory and learning
  • Preliminary research suggests it may help with other cognitive functions, pain, schizophrenia, anxiety, withdrawal symptoms, and brain tumors

Skeptics

  • Insufficient evidence for most benefits
  • Relatively unknown safety profile
  • Some adverse effects reported
  • May increase risk-taking

Health Benefits of tACS

Possibly Effective

Memory and Learning

Using theta waves on the left parietal area, tACS increased working memory as well as factual memory (or declarative) in 4 clinical trials on 84 healthy people and 12 children with ADHD [4, 5, 6, 7].

However, this only worked when the theta waves were synchronized (phase-locked) in 2 clinical trials on 28 healthy volunteers [8, 9].

tACS may also increase memory confidence, as seen in a small trial on 12 healthy women [5].

In another trial on 18 healthy people, gamma-tACS improved working memory better than tDCS (transcranial direct current stimulation) and sham [10].

By using 6 Hz waves on the frontal cortex, tACS improved learning rate in a clinical trial on 50 healthy volunteers [11].

With the same frequency on the temporoparietal cortex, tACS improved learning new words for 12 older adults [12].

All in all, limited evidence suggests that tACS may help with memory and learning. Further research is needed to determine how to use it therapeutically.

Insufficient Evidence17

The following purported benefits of tACS are only supported by limited, low-quality clinical studies on small populations. There is insufficient evidence to support the use of tACS for any of the below-listed uses until larger, more robust clinical trials are carried out.

1) Changing Brainwaves

As found in 3 different studies on 46 healthy volunteers, tACS significantly increased brainwave power for 30 minutes in the wavelength range used to stimulate the brain after 20 minutes of stimulation [13, 14, 15].

With alpha waves (10 Hz), however, it only worked with eyes closed in 2 experiments on 54 healthy people [16].

2) Vision

tACS at 60 Hz on the visual cortex improved contrast detection in a clinical trial on 12 healthy people [17].

tACS on the parieto-occipital cortex at 10 Hz improved object detection in another trial on 14 people [18].

Gamma-range tACS improves vertical motion detection if it’s placed in the right area according to a test with 45 healthy volunteers [19].

3) Movement

Gamma tACS improved movement, but beta tACS worsened it, in a clinical trial on 18 healthy volunteers [20].

With 50 Hz, tACS improved motor function in a clinical trial on 15 healthy right-handers [21].

tACS also increased hand-eye coordination at 80 Hz according to a clinical trial on 14 people [22].

4) Reaction Times

tACS using 10 Hz on the primary motor cortex improved reaction time in 2 clinical trials on 28 healthy volunteers [23, 24].

Similarly, 40 Hz applied on the right parietal lobe improved conscious reaction time in another trial on 23 healthy right-handed young adults [25].

5) Hearing

In a study on 9 healthy volunteers, tACS using 35 Hz on the dorsolateral prefrontal cortex improved pitch memory [26].

tACS improved hearing the frequency used for stimulation in another trial on 14 healthy volunteers [27].

As found by a study on 21 healthy humans using 40 Hz on the temples, tACS improved speech perception, thus having a potential for helping dyslexics and learning a new language [28].

6) Pain

In a clinical trial on 30 people with spinal cord injury, tACS (with a 50 Hz signal) significantly reduced pain [29].

tACS also reduced pain perception in another trial on 23 healthy people, but only when its intensity was unexpected [30].

4 Hz produced pain relief through the mu opioid receptors (acute/cannabidiol and morphine) while 100 Hz acted through the delta opioid receptor (chronic/cannabidiol) in three animal studies [31, 32, 33, 34, 35].

At 4 Hz and 100 Hz, tACS reduced pain in mice through alpha 2A adrenaline receptors (the type of pain ignored in fight-or-flight mode) [36].

7) Improving Neurochemistry

With square waves of 100 Hz put through the earlobes of 38 healthy volunteers, tACS according to a review increased serotonin, beta-endorphin, ACTH, GABA, DHEA, and decreased tryptophan and cortisol in the blood after 20 minutes of stimulation. This suggests tACS might help insomnia and depression [37].

When 15 and 500 Hz were used in 13 healthy volunteers, tACS changed the same neurochemistry corresponding to improvements in symptoms of pain, insomnia, spasticity, depression and headache [38].

Noradrenaline was also reduced by 200 Hz in rats [39].

8) Reasoning

With gamma waves on the left middle frontal gyrus, tACS improved abstract reasoning and logical reasoning in a clinical trial on 20 right-handed people [40].

With theta waves applied to the left parietal area, tACS improved intelligence to solve new problems in another trial on 28 right-handed humans [41].

9) Schizophrenia

With 0.5 Hz and 100 Hz put through the earlobes, tACS helped patients with schizophrenia to have significantly less aggression. They also needed less medication and were restrained less, in a study performed on 9 people [42].

Also, with 4.5 Hz on the dorsolateral prefrontal cortex, tACS improved negative symptoms of schizophrenia in 3 patients [43].

With 10 Hz, tACS reduced hearing hallucinations and restored normal alpha wave oscillations in a clinical trial on 22 people [44, 45].

However, gamma-tACS had no effect on working memory in another trial on 10 people with schizophrenia [46].

10) Drug and Alcohol Withdrawal

In a clinical trial on 21 patients that were on a five-day washout from benzodiazepines, with a signal of 350 Hz, tACS significantly reduced anxiety and insomnia [47].

In a clinical trial on 20 patients that were abstinent for around three weeks, with 70 – 80 Hz square wave pulses, tACS increased MAO-B and GABA, thus increasing resistance to stress and anxiety [48, 49, 50].

11) Tremors

In only 30 seconds with a phase-locking feature, tACS stopped tremors in 12 patients with Parkinson’s; the average patient had a 50% reduction in tremor strength [51].

tACS may also stop tremors in healthy volunteers, as seen in a clinical trial on 23 people. However, only a certain montage type (with extracephalic return contralateral to the primary stimulating electrode) significantly reduced tremors in another trial on 12 healthy volunteers [52, 53].

12) Lucid Dreams

At 25 and 40 Hz of tACS stimulation, people were sent into a lucid dream for 58% and 77% of the time, respectively, in a clinical trial on 27 healthy volunteers [54].

13) Mental Imaging

At 8-11 Hz, tACS prolonged alpha waves in a clinical trial on 23 healthy volunteers. Prolonged alpha waves were associated with a continued increase in mental imaging (visualization performance) [55].

14) Strength

tACS significantly increased muscle power per distance (force per second) when used at 70 Hz in a clinical trial on 18 healthy people [56].

15) Anxiety

In a clinical trial on 12 people with generalized anxiety disorder, tACS at 0.5 Hz and 0.3mA lowered anxiety [57].

16) Brain Tumors

tACS allowed brain tumor patients to live twice as long (median) in a pilot clinical trial on 10 humans. Electric fields also inhibited tumor growth in mice and cell division in cancer cells [58].

tACS Combined with tDCS

Using tDCS of 1mA combined with tACS 0.425 mA of 10 Hz on 20 healthy right-handed volunteers, the phase of the electricity altered their ability to detect sound with a reference phase. This suggests its potential to develop devices that create artificial silence by canceling out surrounding hums [59].

tACS significantly lowered alpha waves (drowsiness) in the occipital lobe (responsible for vision) when placed on the forehead (cathode) and behind the ears (anode) at 70-80 Hz pulsed square waves in a clinical trial on 20 healthy people [60].

Health Risks of tACS

Keep in mind that the safety profile of tACS is relatively unknown, given the lack of well-designed clinical studies. The list of side effects below is not a definite one and you should consult your doctor about other potential side effects based on your health condition and possible drug or supplement interactions.

Some people got red and dry skin after using tACS [58].

Some people also got vertigo, nausea, anger, a metallic taste, a heavy feeling, or intense ear ringing, although 94% felt no negative side effects [37].

So far, no one has experienced memory loss; tACS can’t help hypnotism [37].

Slowing Movement

Both 10Hz and 20Hz on the left primary motor cortex with tACS significantly slowed finger tapping in a clinical trial on 15 people. 10 Hz took 30 minutes to slow it significantly, and 20 Hz slowed it immediately [61].

Triggering Tingle Feeling (Pins and Needles)

With alpha and high gamma frequency ranges, tACS created a sensation of pins and needles, a tingling without pain, in a clinical trial on 14 healthy volunteers [62].

Triggering Flashing Light (Phosphenes)

Seeing phosphenes is a hallucination consisting of seeing light without any light entering the eye.

tACS triggered flickering light with stimulation in the beta range in a light room and with stimulation in the alpha range in a dark room in a small trial on 8 healthy people [63].

Increasing Risk-Taking

With theta waves on the left dorsolateral prefrontal cortex, tACS increased riskier decision-making in a clinical trial on 27 healthy volunteers [64].

About the Author

Carlos Tello

Carlos Tello

PhD (Molecular Biology)
Carlos received his PhD and MS from the Universidad de Sevilla.
Carlos spent 9 years in the laboratory investigating mineral transport in plants. He then started working as a freelancer, mainly in science writing, editing, and consulting. Carlos is passionate about learning the mechanisms behind biological processes and communicating science to both academic and non-academic audiences. He strongly believes that scientific literacy is crucial to maintain a healthy lifestyle and avoid falling for scams.

Click here to subscribe

RATE THIS ARTICLE

1 Star2 Stars3 Stars4 Stars5 Stars
(9 votes, average: 4.56 out of 5)
Loading...

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.