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Cannabidiol (CBD) is emerging as a powerful supplement with anti-inflammatory properties and the ability to help several previously untreatable diseases. It can help fight against cancer and irritable bowel diseases and improve schizophrenia symptoms. Read this post to learn about cutting-edge findings on the health benefits of CBD.

Introduction

cannabidiol

Cannabidiol (CBD) is one of over 80 cannabinoids, natural compounds found in Cannabis sativa – the marijuana plant (R).

CBD and delta-9-tetrahydrocannabinol (THC) are the two main active compounds found in the cannabis plant and are therefore the most recognized and studied.

Unlike THC, CBD does not produce psychoactive effects, and it seems to have natural protection against the marijuana high (R, R2).

CBD has shown promising results as a treatment for a variety of conditions, many of which are otherwise not treatable (R).

CBD in doses larger than conventional therapy can enhance the effect of THC (R).

My Experience with CBD

I have 2 T alleles for the SNP rs1049353 in my cannabinoid receptor (CNR1) gene.

Lower functioning cannabinoid receptors are a fundamental issue of mine. I believe they contributed to my food sensitivities to begin with, so fixing those are my top priority.

In addition, I suspect there are other pathways and epigenetic factors that conspire make it work even less well. This is why I do great on CBD.

Since taking CBD regularly, I have been able to introduce some foods back into my diet without any inflammatory symptoms.

Where to Buy CBD – My Favorite CBD Products

Many CBD products on the market don’t actually contain CBD (based on me observing no results at all from using them). The ones that do are very expensive.

Here are the CBD products that I recommend:

Use this code to save 10% off: 10off347

Health Benefits of CBD/Cannabidiol

1) CBD Fights Against Cancer

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CBD and other chemicals found in Cannabis have an antitumor effect and could be used to improve standard treatments (R).

CBD successfully stopped cancer cells in multiple different cervical cancer cells (R, R2).

CBD increased tumor cell death in leukemia and colon cancer (R, R2, R3).

It also decreased human glioma cell growth and invasion, thus suggesting a possible role of CBD as an antitumor agent (R, R2).

Cannabinoids may be promising tools in combination therapy for breast and prostate cancer, due to their direct antitumor effects, their ability to improve the effectiveness of conventional antitumor drugs, and their usefulness as a treatment to reduce pain (R, R2, R3).

Anticancer Mechanisms:

  • CBD decreased the ability of the cancer cells to produce energy, leading to their death (R).
  • CBD treatment helps lymphokine-activated killer (LAK) cells kill cancer cells better (R).
  • CBD blocks CPR55 signaling, decreasing cancer cell proliferation.

2) CBD Reduces Inflammation and Autoimmunity

Due to its anti-inflammatory role, CBD is a very promising therapeutic agent for a variety of inflammatory and pain-associated disorders.

CBD Can Blunt Th1 and Th2 Dominance

In a rat model of asthma, both Th1 (IL-6 and TNF-a) and Th2 (IL-4, IL-5, IL-13) responses are reduced by CBD treatment (R).

CBD decreased the production and release of inflammatory cytokines such as Th1 (TNF-alpha, IFN-gamma, and IL-6), Th2 (IL-4), and IL-8 (R, R2).

CBD Helps with Th17 Dominance

CBD can help suppressing Th17 dominance, which means that it can help with some Th17-dominant autoimmune diseases (R).

Other Anti-inflammatory Mechanisms:

  • CBD reduces the growth and mobilization of neutrophils (R).
  • CBD reduces the inflammatory Macrophage Inflammatory Protein-1 (MIP-1 alpha, MIP-1beta) (R).

3) CBD May Protect From Neurodegenerative Diseases

CBD was found to prevent toxic effects of neurotransmitter glutamate and radical oxygen species (ROS) in the brain, thus preventing brain cell death (R, R2).

CBD has antioxidant activity greater than vitamin C (ascorbic acid) or vitamin E (α-tocopherol) (R).

CBD may also protect brain cells from beta-amyloid toxicity, making it a potential therapy in Alzheimer’s and Parkinson’s disease (R, R2).

CBD may also protect the brain from in cases where blood flow is reduced (ischemia) (R, R2).

Early human studies showed a dose-related improvement in patients with Parkinson’s disease treated with 100–600 mg/day of CBD over a 6-week period (R).

However, another study failed to show any beneficial effect of a mixture of THC and CBD either on Parkinson’s disease or dyskinesia (R).

CBD has been shown to reverse cognitive deficits of Alzheimer’s disease in animal models (R).

CBD, due to its anti-inflammatory and antioxidant properties, may be a promising agent to treat and prolong survival in Amyotrophic Lateral Sclerosis (ALS) patients (R).

4) CBD May Relieve Multiple Sclerosis Symptoms

Cannabis derivatives may relieve symptoms in multiple sclerosis patients (R).

A combination of CBD and THC is effective and well tolerated in the treatment of muscle tightness, pain, sleep disturbances, and loss of bladder control (urinary incontinence) in people with multiple sclerosis (R, R2, R3).

5) CBD Has Therapeutic Potential for Schizophrenia

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CBD is a potential treatment for psychosis (R, R2).

CBD improves the symptoms of schizophrenia, but the mechanism of action is unknown (R, R2).

Studies suggest that CBD has similar effects as atypical anti-psychotic drugs, but with fewer side effects (R).

6) CBD Helps with Epileptic Seizures

CBD may be a promising therapy for treatment-resistant epilepsy (R, R2).

In a survey including parents of children with treatment-resistant epilepsy, 84% of parents reported a reduction in their child’s seizure frequency while taking CBD (R).

These children also experienced increased alertness, better mood and improved sleep; drowsiness and fatigue occurred as side effects (R).

After 3 months of treatment with a purified 98% oil-based CBD extract, 39% of children with treatment-resistant epilepsy had a more than a 50% reduction in seizures (R).

7 out of 8 patients suffering from secondary generalized epilepsy and resistant to antiepileptic drugs had improvement of their disease state after receiving 200-300 mg/d of cannabidiol for up to 4.5 months (R).

7) CBD Reduces Anxiety

Cannabidiol reduces anxiety in both healthy individuals and patients with social anxiety disorder (R, R2).

Studies showed that CBD significantly reduced anxiety and discomfort caused by public speaking (R, R2).

CBD also reduced anxiety caused by the use of THC (R).

Researchers suggest that it may be effective for panic disorder, obsessive compulsive disorder and post-traumatic stress disorder (R).

CBD is a potential therapy for posttraumatic stress disorder (PTSD) treatment (R).

8) CBD Relieves Pain

Studies suggest that cannabinoids may be a new class of drugs for the treatment of chronic pain (R, R2).

CBD significantly decreased chronic inflammatory and neuropathic pain in rodents (R).

Cannabidiol, especially in a combination with THC, shows promising results for the treatment of postoperative pain, chronic pain associated with multiple sclerosis, cancer, rheumatoid arthritis and neuropathic pain (R, R2, R3).

Sativex, a combination of CBD and THC as a sublingual spray, is effective in treating neuropathic pain in patients with multiple sclerosis and in cancer patients with advanced pain (R, R2).

Study had showed that CBD and opioids act together to relieve pain (R).

9) CBD May Be Beneficial in Rheumatoid Arthritis

Due to its anti-inflammatory effect, cannabinoids may provide relief of joint pain and swelling, and decrease joint destruction and disease progression (R).

Administration of CBD protected joints against severe damage, decreased progression and produced improvement of arthritis in animal models (R).

The first controlled trial showed that administration of Sativex over five weeks produced significant improvements in intensity of pain on movement and at rest, quality of sleep, and inflammation. No serious adverse effects were observed (R).

10) Cannabidiol Relieves Nausea and Increases Appetite

Study showed that CBD relieved nausea and vomiting when it was given to rats (R).

Researchers found that CBD in low doses decreases nausea and vomiting produced by toxic drugs, but in high doses it increases nausea or has no effect in animal models (R, R2).

THC is an approved drug used to treat nausea and vomiting (dronabinol) in human patient, but clinical studies proving the efficacy of CBD are needed in humans (R).

According to the National Cancer Institute, CBD increases appetite by binding to cannabinoid receptors in the body (R).

11) Cannabidiol Lowers Incidence of Diabetes

The study which included 4,657 adult men and women showed that current marijuana use was associated with 16% lower fasting insulin levels, and smaller waist circumferences, a factor connected to the onset of diabetes (R).

Cannabidiol significantly reduces the development of diabetes in young non-obese mice, from 86% in non-treated mice to only 30% in mice treated with CBD (R, R2).

Cannabidiol can inhibit and delay the destruction of insulin-producing pancreatic cells and the production of inflammatory cytokines in diabetics (R).

This data strengthen assumptions that CBD, which is known to be safe in man, can possibly be used as a therapeutic agent for treatment of type 1 diabetes at an early stage of the disease (R).

12) Cannabidiol May Promote Heart Health

Study reported that CBD caused dilation of arteries, and protected blood vessel from damage in animal models (R).

CBD reduced the infarct size (size of damage from clogged blood vessels) in the heart and brain, and irregular heart rhythms in animal models (R, R2).

Studies showed that CBD reduced the heart rate and blood pressure in response to anxiety or stressful situations (R, R2).

CBD also influenced white blood cell function and platelet aggregation (R, R2).

However, further work is required to prove the ability of CBD to prevent the development of heart and blood vessels disorders in humans.

13) Cannabidiol May Treat Depression

According to researchers, CBD has antidepressant-like effects in mice (R, R2).

Study found that antidepressant effects of CBD were fast, continuous over time, and comparable to a common tricyclic medication imipramine, also known as Tofranil (R, R2).

14) Cannabidiol May Help with Inflammatory Bowel Disease

Studies confirmed that CBD prevents colitis in animal models of IBD (R, R2, R3).

The combination of CBD and THC may reduce inflammation and relieve symptoms of IBD such as abdominal pain, diarrhea and reduced appetite (R).

Studies also showed that CBD may be a good candidate to normalize gut motility in patients with inflammatory bowel disease (R, R2).

CBD may reduce gut inflammation severity through activation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) (R, R2).

15) Cannabidiol May Protect Against Bacteria

CBD showed some antimicrobial activity against methicillin-resistant Staphylococcus Aureus (MRSA), a bacterium that can cause difficult-to-treat infection (R).

16) Cannabidiol May Protect From Mad Cow Disease

Cannabidiol has been shown to inhibit prions, the proteins that cause fatal neurodegenerative diseases like Creutzfeldt-Jakob disease and mad cow disease, increasing the survival time of infected mice by almost a week (R).

17) Cannabidiol Promotes Bone Growth

Rodents with broken limbs healed much faster when treated with CBD (R).

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18) CBD Reduces Dyskinesia

Dyskinesia causes involuntary movements.

CBD (combined with a TRPV-1 blocker) reduces the symptoms of dyskinesia in mice (R).

Mechanisms:

  • CBD reduces the production of inflammatory markers
  • Compared with the reference point, CBD decreased the amounts of key enzymes that can cause dyskinesia (R).
  • CBD, together with a TRPV-1 antagonist, reduces Dyskinesia by acting on CB1 and PPAR gamma receptors and reducing the expression of the inflammatory markers COX-2 and NF-kB (R).

19) Cannabidiol May Help with Insomnia

Research suggests that taking CBD before bed improves sleep in people with insomnia (R).

20) Cannabidiol May be Effective for Treating Substance Use Disorders

Studies suggest that CBD may be therapy for substance use disorders.

CBD reduced the rewarding effects of morphine and reduced drug seeking of heroin in animal model (R, R2).

21) Cannabidiol May Help with Quitting Smoking

Research suggests that inhaling cannabidiol for a week might reduce the number of cigarettes smoked by about 40%, without increasing craving for nicotine (R).

22) Cannabidiol May Provide Treatment for Acne

CBD decreases lipid synthesis and proliferation of human sebaceous glands, and has anti-inflammatory effect on sebaceous glands, thus having a potential as a therapeutic agent for the treatment of acne vulgaris (R).

23) Cannabidiol May Play a Role in Psoriasis

CBD reduces the growth of skin cells (keratinocytes), playing a potential role in the treatment of psoriasis (R).

Technical

  • CBD activates 5HT1A receptors and to a lesser extent 5HT2A receptors (R).
  • Activating 5HT1A receptors, CBD exerts effects on nausea and vomiting, depression, appetite, anxiety, sleep and addictions (R, R2, R3).
  • CBD protects the brain from lack of oxygen, at least in part, via 5-HT1A receptor (R).
  • Compared with baseline (but not placebo), CBD decreased resistin and increased glucose-dependent insulinotropic peptide (R).
  • CBD plays a role in perception of pain and inflammation by activating the TRPV-1 receptor (R).
  • CBD’s ability to block anandamide reuptake and FAAH enzyme, thus increasing level of anandamine and indirectly acivating CB1 receptors, make it effective against anxiety and depression (R).
  • Modulating intracellular Ca2+ ions and neuron excitability, CBD can reduce seizures (R, R2).

Caution

When CBD is combined with THC, it causes a temporary lack of drive. There is an impairment of reward learning and motivation (R).

Safety

Hemp nuts sold for dietary consumption are within acceptable standards for the quantity of CBD and THC (R).

CBD is well tolerated, and safe at high doses and with chronic use in humans (R).

Side Effects

CBD decreased the activity of T and B cells which may increase the risk of HIV infection and worsen disease progression, tumor growth and metastases, and exacerbate asthma (R).
CBD can decrease the activity of liver enzymes called cytochrome P450, responsible for metabolizing more than 60% of prescribed drugs (R, R2).
CBD may also cause mild low blood pressure, dry mouth, lightheadedness, and sedation (R, R2).

Dosage

I recommend taking 15-30mg 2X a day.

The Best CBD Oil to Buy

I’ve been looking for a good CBD product for years, but rejected them.  There’s a big problem on the market, where companies are producing CBD products but when they are tested they don’t contain CBD.

After writing this post, I didn’t put any links to CBD products for 5 months, because I didn’t find any products that I liked and that were affordable.

I have a medical marijuana card and the CBD prices were outrageous, which I paid because I think it’s really critical to people with cannabinoid issues.

Here are the CBD products that I recommend:

Use this code to save 10% off: 10off347

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.

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48 COMMENTS

  • Dean Justus

    It is about time. There is hope for chronic pain sufferers, kids with epilepsy, opioid addicted individuals who are struggling. Get behind this legislation, do the research, find out for yourself what the real facts are with this herb. Its been around since the beginning of time. There has never been anyone who had died from it. Get rid of the alcohol it will kill you. Support this issue…Its good for West Virginia. I think it could even save West Virginia, its people and its beautiful landscape from the ravages of Washington

  • THR Technologies

    Great Article. Very helpful post, it has helped me to understand for benefits of CBD oil for health. Thank you for share the information.

  • Cory Warfield

    Selfhacked – you guys always put out such create content!! This was such a great scientific-based explanations, and concise, actionable ways to take advantage of the benefits of this specific cannabinoid. My 100-lb mastiff’s life was saved by using RxCBD dog treats, and I know someone else who’s grandfather has now enjoyed an additional year of life beyond docs’ projections, seemingly due to their ‘Ginger Snap cookies’. I’m an evangelist for #rxcbd, and #cbd in general (obviously). So glad it’s legal in all 50 states, and I appreciate seeing people as awesome as selfhacked shining light on it. Good on you guys!!

  • Every Day Optimal CBD

    Great article. CBD is truly a “self-hack” that more people need to be aware of. Although some of our competitors (some of which who are commenting on this article) have recently been found to have almost ZERO actual CBD in their products…many REAL hemp-derived CBD products are powerful and effective for a wide variety of issues.

  • Julie

    Yes Lesley, they sell it in Holland and Barrett

  • steve

    Have you ever heard of CW Simply by The Stanley Brothers in Colorado?
    That’s the one I’m going to try first-the capsule version

  • Kari

    Hi Carolyn,
    My mom takes it daily for her arthritis, she uses oil 3X a day and said she has not been pain free until now. We live in Canada so it is prescribed. The main thing is to start at around 2.5mg and go from there as you build a tolerance. Also make sure it’s not affecting other medications you are taking. It has the same side effect as grape fruit does with certain pharmaceuticals.

  • Lara Wiliams

    After Legalization of medical use of CBD, It will become the prime focus. Various different CBD products, Specially CBD Oil is in more demand. CBD Oil contains Hemp seed oil and Kosher-Grade Vegetable Glycerin. CBD Oil Can help to cure Anxiety, Alzheimer, Insomnia, Parkinsons’ disease and many more diseases. CBD Oil Can use as a best pain controller.

  • carol close

    This is for Christie September 27, 2017
    Since pot increases alpha and theta sleep, it inhibits delta sleep, so it also inhibits growth hormone and klotho, the anti aging hormone. You may unknowingly be putting your body into a catabolic state speeding the destruction of your connective tissue and breaking down your connective tissue at a faster rate thus aging you faster, instead of building up stronger connective tissue which is your goal in getting healthy, normal, plus staying young.

  • carol close

    This is in reply to Christie… September 27, 2017.
    Ehler Danlos has recently been found to be caused by hereditary alpha tryptasemia with mast cell activation. You are born with extra copies of the alpha tryptase gene. Tryptase levels can be lowered by lactoferrin found in the supplement colostrum. Also, supplement with luteolin which inactivates mast cells. The cells of connective tissue include fibroblasts, adipocytes, macrophages, mast cells and leucocytes. Histamine activates mast cells increasing inflammation which attacks connective tissue, so eat an anti-histamine diet which lowers inflammation. To lower histamine levels, eat only fresh foods- eggs, chicken, rice, gluten free pasta/crackers, cream cheese, butter, coconut oil, olive oil, non-citrus juices, milk, herbal teas (not coffee, black tea), fresh/frozen fish, fresh/frozen fruits and vegetables, especially prebiotics like onions, garlic, bananas, jicama, raw asparagus. No tomatoes, strawberries, vinegar, matured cheeses, pickled/canned foods, shellfish, salami and other cured meats, sausages, ham, bologna, etc. No beans, nuts chocolate, peanut butter, ready meals, deli food because its been sitting, energy drinks, as these are all high in histamines. The key to low histamine is fresh. Eat knox gelatin daily with vitamin C which strengthens connective tissue. Gelatin is high in the amino acids- glycine, proline and lysine which are needed for collagen production in connective tissue. No aspirin, alcohol, high sugar, fructose, or high carbs to heal leaky gut. In fact, inflammation throughout the body can be mediated by the gut bacteria, and loss of gut bacterial diversity can threaten the gut lining, so then that leakiness of the gut, or intestinal permeability, then mechanistically leads to inflammation. Bacteria from the gut leaks into the bloodstream causing inflammation. Then where does that inflammation go and what part of the body gets damaged from it? Connective tissue. Inflammation is the cornerstone of basically every degenerative condition you don’t want to get. Check your progesterone levels which should be normalized. Progesterone’s role in the health of the body’s connective tissue or collagen is well understood. As progesterone strengthens collagen and increases the turnover of cells, the skin becomes softer and stronger. 70% of the skin is collagen, as is 20% of the entire body- tendon, ligament, blood vessels, skin, cornea, cartilage, bone, blood, blood vessels, gut, intervertebral disc, brown and white adipose tissue. https://www.niaid.nih.gov/research/hereditary-alpha-tryptasemia-faq

  • Someone

    Please look into DCA for her, it’s is proven to shrink tumors.

  • Martin Jones

    Agreed with this blog. CBD is best to treat anxiety, depression, pain, chronic pain, inflammation, Alzheimer’s and many more diseases. I’ve experienced good qualities of CBD. I was suffering from the chronic pain for a very long time. One of my friends suggested me to take CBD oil which can treat my pain. I took it for a few weeks twice a day and the pain was totally gone. I felt more relaxed and calm than ever before. I am wondering that how CBD can cure this much effectively? I love CBD and I recommend it to people.

  • Aaron middleton

    CBD is awesome. I use it to treat my back pain and anxiety and I must say it works 🙂

  • Misty Goodman

    I’m working with a company. That is going global. I can send you info through email.

  • Martha Brown

    CANNABIS OIL CURED MY MOM ALZHEIMER’S

    My name is Martha, My mom has dementia and Alzheimer’s disease, I took care for my mum. We were managing until these awful vigorous shaking seem to have took over her body, she can’t even hold a cup when it is at its worst and sleep is out of the question which leads to utter exhaustion. We were told that the medication she was on for her restless legs which was something totally different was making the shaking worse. But yet the shaking is part of the dementia. I was making research online on any possible solution that could help my mom and I came across how cannabis oil have helped a lot of people around the world to cure Alzheimer’s and Dementia. I was so happy and relief when I saw this and I knew there was hope for my mom to be well again. I contacted Medicinal Marijuana Resources to get the high quality THC cannabis oil for treatment and prescription on how to use the cannabis oil for treatment of Alzheimer’s and Dementia. My mom started using the cannabis oil for treatment as directed by Medicinal Marijuana Resources physician expert team. Now the Alzheimer’s and Dementia are gone and my mom is well, healthy and strong again

  • Christie

    This is an amazing product! I have Ehlers Danlos type 3 & 4. I have been living with chronic pain since my early twenties. I am now 41 yrs old and can say that today, because of Rapid Releaf and their incredible people, I feel better than I have in a long time. After 31 surgeries for various skeletal problems(I have three total joint replacements)I just assumed my life would always include pain and anxiety medication. I called Rapid Releaf and was helped by Josh. He took as much time as I needed to explain their product and how he thought it could help me. Three days after starting the CBD oil regimen, I am almost completely off of the narcotics. I have stopped taking all of my anxiety meds( I took Xanax and Valium for almost 15 years) and am currently working a program designed specifically to my needs and situation. I have slept more and feel rested in the morning. I can’t say thank you enough for giving me a life back! No more every day doctor visits or trips to the pharmacy. I am living a life that I never dreamed could be mine. I am living a normal everyday life under extraordinary circumstances! Thank you for the time you have dedicated to me and my situation. I know I couldn’t be almost drug free within days of starting your program otherwise. It truly is a miracle to be able to go day to day, unrestricted by pain and the tie downs that come with prescription medications. I have more time and energy than I thought would be possible as I transition from a twenty year opiod dependent life, to one having nothing to hold me back.

  • Cindi

    Can you put it in a vape and just hit it all day or is there a limited amount to ingest ?

  • Amanda

    How to sensibly buy LEGAL cbd oil online? Because I got a letter saying customs has confiscated my package two times already and i’m pissed.

    1. Nattha Wannissorn, PhD

      Depends on where you are.

  • Dianna Goforth

    How does CBD Oil help Alzheimer’s?

  • April

    I just want to share how CBD changed my life. I am using water soluble CBD to calm the autoimmune response. It works to reduce inflammation, seizures, nerve pain, and in reducing tumors. It’s truly God-sent! – April

  • Carolyn Doull

    I am a senior who would like to try CBD for inflammatory bowel problems, but where to start? Capsules? Tinctures? Liposomes? How do I know what dosage to take? I find it confusing and need a guideline.

  • Lesley

    Can u get this in the uk

  • Rose Baumann

    I have just started on my CBD journey. This is day 3. My knees do not hurt and I am definitely able to tell the difference when things were off. The nights are pain-free. I have a job that I spend a lot of time on my feet, and easily do over 14000 steps just for my job. My feet use to hurt so bad by the end of the night, that I actually would cry on the drive home. This allows me to have much less pain, and an easier time falling and staying asleep

  • carol close

    Regarding your comment on CBD and colitis or inflammatory bowel disease. Immune cells patrol the gut to ensure that harmful microbes hidden in the food we eat do not sneak into the body. Cells that are capable of triggering inflammation are balanced by cells that promote tolerance, protecting the body without damaging sensitive tissues. When the balance tilts too far toward inflammation, inflammatory bowel disease can result. Now, researchers have found that a kind of tolerance-promoting immune cell appears that carry a specific bacterium in guts called Lactobacillus reuteri that is the normal part of the gut microbiome, and tryptophan, part of a protein-rich diet, soothes the inflamed gut because it increases the development of a population of immune cells that promote tolerance. Further, the bacterium needs tryptophan — one of the building blocks of proteins — to trigger the cells’ appearance, and the more tryptophan in the diet to feed the gut bacterium, Lactobacillus reuteri, the more of these immune cells there are.

    https://www.ncbi.nlm.nih.gov/pubmed/28775213 Lactobacillus reuteri induces gut intraepithelial CD4+CD8αα+ T cells

    Regarding Cannibis and Klotho and Cannibis and the Endocrine System
    Cannabis and alcohol both increase alpha and theta sleep and decrease delta sleep. Cannabis and alcohol inhibit delta sleep needed for the night time brain housekeeping duties and increase luteinizing hormone so core body temperature does not drop for brain cells to shrink for 60% more space between brain cells for the cerebral spinal fluid to wash out toxins. Since pot inhibits delta sleep, it also inhibits growth hormone and also dehydrates you, so klotho is reduced. Cannabis causes kidney stones by reduced klotho. Klotho is anti tumor, anti dementia, inhibits arteriosclerosis, osteoporosis, and skin atrophy, so since cannabis inhibits klotho, aging is increased. Cannibis decreases sex hormones, increases stress hormones, impairs fertility, inhibits copulation, reduces oxytocin-the love and protection hormone.

    https://www.ncbi.nlm.nih.gov/pubmed/19045957 The nonpsychoactive Cannabis constituent cannabidiol is a wake-inducing agent. lateral hypothalamus or dorsal raphe nuclei, which are wake-inducing brain areas which cannabidiol enhances wakefulness and decreases slow wave sleep and REM sleep. Furthermore, cannabidiol increases alpha and theta power spectra but diminishes delta power spectra. Additionally, cannabidiol increases c-Fos expression in lateral hypothalamus or dorsal raphe nueclei. These findings suggest that cannabidiol is a wake-inducing compound that presumably activates neurons in lateral hypothalamus and dorsal raphe nuclei.

    https://en.wikipedia.org/wiki/Delta_wave Delta waves sleep releases growth hormone and prolactin

    https://en.wikipedia.org/wiki/Glymphatic_system Delta sleep needed for function of glymphatic system.

    https://www.ncbi.nlm.nih.gov/pubmed/24096965 Growth hormone and Klotho. Growth hormone increases klotho for proper kidney function and calcium regulation.
    (Reduced klotho is involved in kidney stones, chronic kidney failure, tumors, dementia, arteriosclerosis, skin atrophy, and more.)

    https://www.ncbi.nlm.nih.gov/pubmed/26408166 Endocannabinoids and the Endocrine System in Health and Disease.

    In this review, the effects of cannabinoids in the regulation of the following endocrine systems are discussed: the hypothalamic-pituitary-gonadal axis and hypothalamic-pituitary-adrenal cortex axis. Cannabis users have reduced levels of gonadotropins, reduced prolactin and growth hormone. Cannabis affects corticotropin-releasing hormone-, thyrotropin-releasing hormone-, vasopressin-, and oxytocin-expressing neurons. Therefore, our findings reveal a mechanism of rapid glucocorticoid feedback inhibition of hypothalamic hormone secretion via endocannabinoid release in the paraventricular nucleus of the hypothalamus and provide a link between the actions of glucocorticoids and cannabinoids in the hypothalamus that regulate stress and energy homeostasis. Glucocorticoid negative feedback in the brain controls stress, feeding, and neural-immune interactions by regulating the hypothalamic-pituitary-adrenal axis. Cannabis increases dopamine which decreases prolactin. Cannabis decreases oxytocin, thyroid hormone and growth hormone, and disrupts the hypothalamic-pituitary-adrenal axis. Cannabinoids suppress fertility via reducing hypothalamic gonadotropin- releasing hormone output. γ-Aminobutyric acid (GABA)(A) receptor (GABA(A)-R)-mediated transmission is a major input to gonadotropin releasing hormone cells that can be excitatory. Cannabinoids act via inhibiting GABAergic input. Cannabis disregulates the hypothalamic-pituitary-adrenal axis circadian rhythm. Cannabis decreases serum concentrations of pituitary gonadotropins. Cannabis raises cortisol and ACTH which increases cortisol which uses up progesterone reducing testosterone and estrogen. Cannabis lowers testosterone in men by inhibiting testosterone secretion and impairs fertility in males through alteration in the testicular endocannabinoid system. Cannabis suppresses copulatory behavior even when testosterone levels are maintained. It decreases sperm concentration, causes defective sperm function or alteration of sperm morphology. Endocannabinoids control male reproduction acting at central and local level via cannabinoid receptors. The cannabinoid receptor CB1 has been characterized in the testis, in somatic and germ cells of mammalian and non-mammalian animal models, and its activity related to Leydig cell differentiation, steroidogenesis, spermiogenesis, sperm quality, and maturation. Testicular degeneration and necrosis is induced by chronic administration of cannabis. In both ovulating and menopausal women, cannabis can alter pituitary gonadotropin release and alter metabolism or target tissue response to gonadal steroids, leading to reduced estrogen and progesterone production and anovulatory menstrual cycles. Cannabis presents abnormal longer ovulatory cycle lengths in females. Cannabis suppresses luteinizing hormone when sex hormones are initially high, but, chronic cannabis lowers progesterone and testosterone in men, and lowers estrogen and progesterone in women, so luteinizing hormone significantly increases which raises night time core temperature for disrupted sleep. Cannabis increases hypothalamic nitric oxide which inhibits oxytocin. Cannabis is detrimental for lactating moms. Cannabis decreases maternal care, decreases aggressive instinctual behaviors for protection of young, suppresses maternal anxiolysis, decreases plasma oxytocin levels and milk consumption and decreases activation of oxytocinergic neurons in hypothalamic nuclei. Changes in the behavioral responses of lactating mothers treated with cannabis can be related to disruption in the neuroendocrine control of oxytocin secretion. Cannabis causes impairment of glucocorticoid feedback which either enhances or decreases performance on various tasks. Cannibis can cause a decrease in thyroid which negatively affects cerebellar development and motor performance involved in adult brain function. It induces consistent behavioral changes in adults, leading to severe anxiety and morphological changes in the hippocampus, however, it shows improvements for schizophrenia: improvement in cognitive function and reduction of antipsychotic-side. Cannabis and Δ(9) -THC are anticonvulsant in most animal models but can be proconvulsant in some healthy animals. The simultaneous rapid stimulation of nitric oxide and endocannabinoid synthesis by glucocorticoids has important implications for the impact of stress on the brain as well as on neural-immune interactions in the hypothalamus. Cannabis has implications for psychosis. There are blunted psychotomimetic and amnestic effects with cannabis. Lithium increases oxytocin and helps in cannabis withdrawal, and pregnenolone/progesterone help in cannabis withdrawal as estrogen generally increases and progesterone decreases sensitivity to marijuana.

  • Dave

    great articel. I’m using the Elixinol and its really effective for my anxiety. Glad to read all
    the benefits!

  • Hemp cbd

    I use the CBD (Elixinol) which helps me, I feel great! I believe this product.

  • Lisa

    Thanks Emily. I had a bad reaction as well. I felt fantastic on a minuscule dose ( 3 drops, Biologix) , but a few hours later I destabilized and was in bed for about 3 hours before I could get up. Happened 2 days in a row. I was so happy about how great I felt, but it is not worth the crash.

  • gwen

    Joe, which product do you take? 3600mg, 300mg? what about the liposomal version? which one would be the most cost-effective?

  • Mr. sick

    Sorry to hear that it didn’t work out well for you, Emily, but what you are describing here isn’t a cannabis high. It’s a bad reaction though.

  • MMJ Canada

    Hi Nattha! Been reading a lot about the benefits of CBD Oil, I’m just wondering if you could use the oil directly on an inflamed muscle or skin? I mean, does it always work best when ingested?

    1. Nattha Wannissorn, PhD

      I don’t know. CB2 receptors are present in muscle cells. You could try it and see how it’s like. There are transdermal CBD products on the market so that’s likely to work.

  • Emily Porter

    For the record, for all the super sensitive people out there, I want to comment that CBD oil CAN get you high. NO REALLY. It can. And I’m talking about Elixinol. the recommended brand here, not some random adulterated stuff, not some high cbd marijuana, actual purified, tested, industrial hemp oil. I have chronic fatigue syndrome and experienced with my own body all the same effects from Elixinol, that I have gotten from eating a weed cookie (less intense, but still unpleasant). For me these side effects include full body convulsions and tremors lasting over an hour, anxiety and panic, disturbing disassociative and repetitive/confusing thought patterns, cottonmouth, and intense emotions and weeping. This was from 90mg CBD content at once. Which is more than recommended on the bottle but still well within the realm of a reasonable dose. Like an edible the effects took many hours to kick in, and then the high came on fast. I am also largely intolerant of caffeine and alcohol. However I never have any noticeable effects from most vitamins and herbal products. Not against CBD. Just saying it is possible, even if no one believes you.

  • greenroads

    CBD has played a major role in treating numerous health care problems such as cancer, diabetes, chronic pain, and many other. Research has found that a 600mg dose of CBD helped people in reducing their anxiety to give their speech. It is safe to use if proper medication has been done and does not cause any side effects.

  • Jhodson

    Really? Really? I’m not trying to be rude, but this statement is ridiculous: “Many CBD products on the market don’t actually contain CBD (based on me observing no results at all from using them)”
    You can’t make such claim based on your subjectivism. Go test these CBD, show us the result and THEN you are able to make this kind of statement.

  • tony

    What information or evidence do you base this statement on? “Many CBD products on the market don’t contain any CBD”

    1. Nattha Wannissorn

      He observed no effect from them.

      1. tony

        Oh so an assumption/guess based on a single anecdote is thrown in there as a factually worded statement on a blog about evidence based health info?

        1. Nattha Wannissorn

          It’s a blog that shares both science and personal experimentation results. I’ll edit that to make it clearer.

  • Mike Mills

    What are your thoughts on vaping an eliquid and its effects related to ingestion of an oil compared to water vapor? Would I essentially be able to take more CBD into the blood stream that way compared to taking it sublingually?

    1. Nattha Wannissorn

      They just reach your bloodstream and get eliminated at different speeds.

  • Claire Higham

    Can you make your own by soaking high CBD Hemp buds in oil?! Seems alot easier and cheaper

    1. Nattha Wannissorn

      No

  • James

    I get my CBD products and have been using them for over 6 months to help with my anxiety. I recently got my best friends mother (who has rheumatoid arthritis) to try the higher strengths and she told me that it has helped her tremendously. Would definitely recommend this company to anyone who is looking at CBD for help!

  • Phillip

    Thanks for the CBD oil recommendation. Do you all know if CDB oil is legal to purchase in states where medical and recreational marijuana is illegal?

    1. Nattha Wannissorn

      We checked with the company and they say that because CBD does not have psychoactive properties, it’s considered a dietary supplement which can be sold in all states.

  • Emily Elson

    I am confused about how you say it can be beneficial for cancer and has anti-tumor effects, but then in the side effects, you say that since it can lower T and B cell activity it can worsen disease progression, tumor growth and mestastases. My mom has early stage multiple myeloma as well as some anxiety/depression and insomnia. Thought this would be good- but now confused whether it’s anti or pro cancer.

    1. Nattha Wannissorn

      It depends on where it is in the process because cancer is a complex disease. The research on this is still coming out. I’m inclined to think that it helps more than hurts in this case, but correct me if I’m wrong.

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