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Coenzyme Q10 and Ubiquinol (CoQ10)

Coenzyme Q10 and its derivative Ubiquinol have antioxidant properties. They can also fight cancer, reduce diabetes symptoms, protect the liver, and promote newborn health. Learn about its many health benefits below.

Introduction

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Coenzyme Q10 (CoQ10) is a coenzyme present in most cell bodies of animals and is located primarily in the mitochondria. Ubiquinol is a derivative of CoQ10 that is fully reduced and saturated with extra electrons to assist in bodily absorbance (R).

Both CoQ10 and ubiquinol are key components in the electron transport chain, facilitating the production of ATP in redox reactions (R).

Ubiquinol, being fully reduced, is absorbable by the body, allowing it to be sold as a supplement for those suffering from a CoQ10 deficiency (R).

The Ubiquinol That I Recommend

Health Benefits of  Coenzyme Q10 

1) Ubiquinol Prevents Cell Stress

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Supplementation of ubiquinol before strenuous exercise in human patients decreased oxidative stress levels (R).

Ubiquinol increased all levels of antioxidants and total antioxidant capacity in the body post-exercise (R).

Ubiquinol taken over a two-week period increases endothelial cell function, cell energy, and muscle recovery post-exercise (R).

Also, oral supplementation of ubiquinol reduces overall blood pressure in athletes after strenuous amounts of work over a long period of time (R).

2) Ubiquinol and CoQ10 Have Antioxidant Properties

Ubiquinol applied topically replenishes skin levels of Coenzyme Q10, not only on the skin surface but also in the deeper layers of the epidermis. Topical ubiquinol increases cell metabolism and healing in damaged human keratinocytes (R).

CoQ10 decreases the levels of free radicals in the skin and increases the levels of antioxidants in human patients (R).

Both male and female smokers have a diminished capacity to produce CoQ10 which leads to an increase in free radicals and damaged tissue in the lungs. Supplementation of ubiquinol counteracts the depletion of CoQ10 and reduces the chance of lung damage due to decreased coenzyme (R).

In rats, CoQ10 treatment reduced hepatocyte death and increased overall albumin, protein, and lipid levels in the liver. CoQ10 restored antioxidant levels in the liver while also reducing oxidative damage (R).

Ubiquinol taken by healthy human patients increased antioxidant capacity in the heart (R).

In elderly human patients suffering from heart failure,NT-proBNP levels are indicators of disease severity. Daily intake of ubiquinol reduced NT-proBNP levels entirely, reducing the effects of heart disease and the chance of heart failure (R).

Intake of ubiquinol by children suffering from both H1N1 and seasonal influenza increased the antioxidant capacity to normal levels. Ubiquinol reduced the oxidative stress due to infection in child patients, while not affecting other types of medication used to fight the infection (R).

3) Ubiquinol and CoQ10 Combats Cancer

Ubiquinol is used as a marker for human patients developing lung adenocarcinomas leading to lung cancer, allowing protective measures to be taken (R).

Human lung cancer patients have decreased antioxidant capacity and increased oxidative cell problems leading to further development of carcinomas. Intake of ubiquinol increases the antioxidant levels in cancer patients while decreasing oxidant generation leading to the formation of carcinoma cells (R).

Ubiquinol taken by human patients suffering from clear cell renal cell carcinoma increases survival rates through increasing cell metabolism even after kidney removal (R).

Mice treated with Coenzyme Q10 were able to increase ubiquinol levels and antioxidant capacity to prevent the formation of cancer cells due to UV radiation (R).

4) CoQ10 Reduces the Effect of Diabetes

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In rats with diabetes, supplementation of CoQ10 increased the bioavailability of the coenzyme that is normally reduced due to diabetic damage (R).

CoQ10 decreased non-fasting glucose and blood pressure in rats (R).

In human diabetic patients suffering from diabetic eye damage, supplementation of ubiquinol and CoQ10 reduces and reverses its effects and improves nerve function (R).

5) Ubiquinol and CoQ10 Prevent Liver Damage

In patients taking statin drugs (to lower cholesterol), hepatotoxicity can be a serious side effect. Coenzyme Q10 taken as a ubiquinol supplement reduces the MicroRNA indicative of drug-related liver damage (R).

Ubiquinol protects hepatic cells in the liver, preventing serious damage when taking statin drugs regularly (R).

Additional supplementation of CoQ10 reduces the deficiency experienced by the liver when taking excess amounts of drugs (R).

Liver myopathy is reversed with CoQ10 supplementation without damaging the tissues (R).

6) Ubiquinol Promotes Fertility and Newborn Health

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Ubiquinol taken by men promotes antioxidant capacity and reduces oxidative stress in sperm, increasing their count and motility (R).

Women who take ubiquinol and CoQ10 supplements while pregnant increase overall ubiquinol levels in umbilical arterial and umbilical venous blood, reducing fetal stress during development (R).

In developing bovines and humans, high levels of ubiquinol-cytochrome (ubiquinol protein) serve as markers for increased bone size and density for body measurement once the fetus is born (R).

7) CoQ10 Reduces Surgical Complications

CoQ10 taken in high doses before and after cardiac surgery helped prevent complications during the surgery (R).

Human patients in post-op recovery after arterial heart surgery were 95% less likely to suffer from heart complications if they took a high dose of CoQ10 (R).

After bypass surgery, patients taking high amounts of CoQ10 had lower amounts of inflammation. This shortened ICU time and reduced the chance for future infection (R).

8) CoQ10 Ubiquinol Eases the Symptoms of Autism

Children suffering from autism spectrum disorder showed improvement in core symptoms when taking CoQ10 (R).

Children aged 3-6 years who are diagnosed with autism and treated with ubiquinol show improvement in parent communication, verbal communication, playing games, sleeping, and food acceptance (R).

9) CoQ10 Combats Statin Drug Side Effects

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Statins are drugs that help lower cholesterol.

Patients suffering from statin-related muscle pain, muscle strength degradation, and decreased aerobic activity can increase performance through daily intake of CoQ10without other symptoms (R).

Statin drugs can induce rhabdomyolysis (muscle death) which release rhabdomyosarcoma cells into the bloodstream, degrading other tissues. Human rhabdomyosarcoma cells treated with a CoQ10 supplement alongside simvastatin reversed muscle death and killed off remaining sarcoma cells (R).

Mice administered with simvastatin had decreased levels of CoQ10. This lead to decreased cessation of spontaneous heart beats and decreased sensitivity to electrical stimulation. Coadministering simvastatin alongside CoQ10 allowed the simvastatin to have proper effects. It also combats the negative side effects in the hearts of mice (R).

Alongside daily exercise and ubiquinol supplementation, patients saw an even greater increase in high-density lipoprotein, reducing coronary heart disease related issues (R).

10) CoQ10 Improves Fibromyalgia in Juveniles

In juveniles suffering from fibromyalgia pain, CoQ10 levels were below average. Supplementation of ubiquinol relieved pain and muscle soreness increased cholesterol metabolism, and overall fatigue levels (R).

Technical

  • Also, the isoprostanes, 8-OHdG, oxidized LDL, and hydroperoxides in the supplemented Ubiquinol group lowered. Total antioxidant status, fat-soluble antioxidant (both plasma and membrane), and CAT activity increased (R).
  • However, diastolic BP in the CoQ10 group is significantly lower than that in the placebo group (P<0.05) (R).
  • Plasma creatine kinase (CK) and myoglobin (Mb) concentrations significantly increased in both groups during the camp (P<0.05). Whereas there are no significant differences in CK and Mb between CoQ10 and placebo groups (CK: P=0.82, Mb: P=0.69) (R).
  • H1N1 patients had significantly decreased TAC, CoQ10 and Zn levels (1.01 +/- 0.19, 752.2 +/- 163, 69 +/- 27, respectively). This is compared to Control Group (1.64 +/- 0.36, 934 +/- 21, 92 +/- 4, respectively) (R).
  • Treatment with simvastatin significantly reduced mitochondrial content. Also, it lowered cell viability (R).

Side Effects

Many forms of treatment use CoQ10 in high doses due to its limited side effects. However, some side effects do present themselves, especially if the patient is allergic to the supplement ubiquinol. Some side effects include:

  •    Upset Stomach
  •    Diarrhea
  •    Nausea
  •    Loss of appetite
  •    Mild insomnia
  •    Rash

Dosage

Ubiquinol doses vary based on the type of medication taken and the reason for taking it.

In order to maintain healthy blood levels, consumers should take approximately 25-50 mg per day.

If consumers are looking to improve brain function, 150-200 mg should be taken per day.

When purchasing Coenzyme Q10 or ubiquinol for supplementation, the two ingredients needed for successful absorption are either BioQ10 or Ubiquinol, both in a soft gel capsule. They are sold as either 100 mg capsules or 300 mg capsules.

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Jarrow Formulas Ubiquinol QH-Absorb, High Absorption/Enhanced Stability, 100 mg, 120 Softgels
  • "Active Antioxidant" Form of Co-Q10
  • Q-Absorb High-Absorption System
  • Ubiquinol High Absorption Softgel: 2 Dosages: 100 & 200 mg
  • Results in Higher Blood Levels Than Co-Q10*: Especially for older consumers
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Doctor's Best Best Ubiquinol Featuring Kaneka's Qh (100mg), 60-Count
  • Powerful antioxidant actions
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  • Supports mitochondria to enhance cellular energy production
  • Label images may vary

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