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10 Surprising Celadrin Benefits (Cream/Softgel) + Side Effects

Written by Dhwani Korde, MS (Neuroscience) | Reviewed by Ana Aleksic, MSc (Pharmacy) | Last updated:
Jonathan Ritter
Medically reviewed by
Jonathan Ritter, PharmD, PhD (Pharmacology) | Written by Dhwani Korde, MS (Neuroscience) | Reviewed by Ana Aleksic, MSc (Pharmacy) | Last updated:

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arthritis in hands

Celadrin is a topical cream or capsule used to treat arthritis and pain. After its main component was discovered in the 1970s, it has grown in popularity and now shows promise in treating other diseases, such as psoriasis and cancer. Keep reading to learn more about the health benefits of Celadrin.

What Is Celadrin?

Celadrin is a fast-acting anti-inflammatory natural compound that treats arthritis and improves joint function and mobility [1].

It is a mixture of cetylated fatty acids, which are formed by combining naturally occurring fats with acetyl alcohol.

Myristoleic acid was discovered in the 1970s in mice that were immune to arthritis. It was combined with cetyl alcohol to form cetyl myristoleate, the first cetylated fatty acid and the main component of Celadrin [2].

Celadrin is different from other pain-reducing creams (such as lidocaine or methyl salicylate) as it relieves pain but doesn’t cause side effects [3, 4, 5].


Celadrin is a mixture of various cetylated fatty acids, including [5]:

  • Cetyl myristoleate (most common)
  • Cetyl myristate
  • Cetyl palmitoleate
  • Cetyl laurate
  • Cetyl palmitate
  • Cetyl oleate

It may also contain menthol as an additional active ingredient [4].

How It Works

Celadrin acts to reduce inflammation and pain by:

  • Reducing the production of inflammatory compounds, prostaglandins (by blocking the COX-2 enzyme) [6].
  • Reducing the release of chemicals that increase inflammation from white blood cells (leukotriene B4 and interleukin-1) [4].
  • Surrounding the affected joint, making it easier for another anti-inflammatory agent (creatine) to access the affected cells and reduce inflammation (according to a patent filed by the All American Pharmaceutical) [7].
  • Regenerating cartilage and improving joint health. It protects cartilage from damage and provides more cushioning for the joint (by preventing the uptake of large amounts of arachidonic acid, according to a patent filed by the Life Science company) [8].
  • Reducing tissue damage by blocking the enzyme (thromboxane-A synthase) that makes thromboxane, a chemical that increases inflammation and may cause cancer [9, 10, 11].

Health Benefits of Celadrin

1) Reduces Pain in Arthritis

In a study on 64 patients with osteoarthritis, taking Celadrin capsules for 68 days improved knee flexibility and decreased the aches and pains caused by arthritis compared to the placebo group [5].

In another study of 42 patients with osteoarthritis, Celadrin cream greatly improved quality of life, such as getting up from a seated position and climbing stairs (compared to the placebo group). They also experienced less pain and stiffness in their knees just 30 minutes after using it [12].

Celadrin cream reduced pain, improved posture, and increased standing stability in 40 patients with osteoarthritis in a study after 30 days of treatment [3].

In a study of 28 patients with osteoarthritis of the knee, elbow, and wrist, Celadrin cream combined with menthol reduced pain and improved functional performance after 1 week, compared to the placebo group [4].

A combination of cetylated fatty acids and creatine reduced joint and muscle inflammation when taken for 30 days in 35 patients, according to the patent filed by All American Pharmaceutical [7].

A fatty acid mixture containing cetyl myristoleate effectively reduced knee pain in 24 subjects with mild arthritis [13].

In rats, injection of a specific cetylated fatty acid (cetyl myristoleate) prevented the development of arthritis [2].

2) May Improve Knee Function

In a study of 28 patients with knee arthritis, Celadrin cream improved stair-climbing ability, balance, a range of motion of the knee, and strength [4].

A study of 40 patients with knee arthritis found that after using Celadrin for 30 days, patients experienced improved balance, strength, and knee mobility [12].

According to a trial conducted by Imagenetix, osteoarthritis patients taking Celadrin for 8 weeks could walk a greater distance in 6 minutes [14].

In dogs, using Celadrin for 30 days improved mobility and joint health [15].

3) May Reduce Muscle Pain

In a study of 72 patients with chronic neck pain, using Celadrin twice daily with physical therapy reduced pain and improved neck mobility [16].

4) May Reduce Blood Clotting

When combined with glucosamine, Celadrin prevented the formation of blood clots (by preventing platelet clumping) in 24 healthy subjects. This protects the heart and blood vessels and reduces the chances of heart attack and stroke [1].

5) May Improve Psoriasis

In a small pilot study (DB-RCT) of psoriasis patients, Celadrin improved disease symptoms (skin scales, patchiness, redness, dryness, cracks, and raised skin) [17].

According to the patent filed by Meracol Corp Ltd., the cetylated fatty acids cetyl myristate and cetyl palmitate reduced symptoms of psoriasis in patients with eczema [18].

6) May Help with Autoimmune Disease

One cetylated fatty acid (cetylated myristoleate) may improve autoimmune diseases, including [19]:

  • Addison’s disease (a condition where kidney glands do not produce enough hormones)
  • Autoimmune liver inflammation
  • Behcet’s disease (blood vessel inflammation)
  • Lupus
  • Antiphospholipid syndrome (a disorder where the immune system attacks normal blood proteins)
  • Multiple sclerosis
  • Sjogren’s disease (a disorder that causes dry eyes and mouth)

7) May Protect Cartilage

Celadrin may protect cartilage stores in the joints by preventing the uptake of arachidonic acid, a fatty acid that interferes with cartilage growth (according to the patent) [8].

8) May Reduce Fibromyalgia

In an open pilot study of 13 patients with fibromyalgia, cetyl myristoleate (the main component of Celadrin) reduced general pain, fatigue, and sleep disturbances caused by the disease [20].

9) May Improve Diabetes

Celadrin may improve symptoms of diabetes by reducing inflammation, one cause of type 1 and type 2 diabetes [21, 22].

10) May Fight Cancer

In cells, Celadrin could help fight cancer by blocking an enzyme (thromboxane synthase) that produces thromboxane, which is associated with breast cancer [23].

Celadrin may also stop cancer from spreading in the body by reducing inflammation [24].

Side Effects & Precautions

There are few known side effects of using Celadrin. No side effects were reported in clinical trials [4, 3, 12, 5].

Some people may be allergic to Celadrin, as 2 fibromyalgia patients withdrew from a trial after experiencing indigestion and developing rashes [20].

Drug Interactions

Using Celadrin with blood thinners (heparin or warfarin) should be avoided as both reduce blood clotting, which may lead to uncontrollable bleeding. Celadrin reduces platelet formation, while heparin and warfarin slow the body’s ability to make clots.

However, this interaction has not been studied yet.

Limitations and Caveats

There are few studies that examine the effectiveness of Celadrin in diseases other than osteoarthritis, including cancer, autoimmune disorders, diabetes, and psoriasis. The limited studies are either pilot or low-quality trials with no follow-up. They also have a small number of subjects.

The interaction of Celadrin with other drugs is unknown.

Additionally, the safety of specific Celadrin components such as cetyl myristoleate has not been established.

Celadrin Supplementation

Celadrin is available as cream or softgels.

Fatty acid mixtures are extracted from beef fat and then treated with cetyl alcohol obtained from palm oil. The resulting cetylated fatty acids are then used to make Celadrin [25].

Cetyl myristoleate is found naturally in sperm whale oil, and in a small gland in the male beaver [26].

Cetyl palmitate is produced from palmitic acid, which is found in palm oil or Chinese vegetable tallow. Cetyl oleate is produced from oleic acid, which is found in olive oil, according to a patent filed by the Deva Holding Company [27].


The recommended oral dosage of Celadrin is 1,000 to 1,500 mg daily [1].

When used as a cream, it is applied twice a day to the affected area including the knee, wrist, and elbow [4].

There is no safety data about dosage in young children, pregnant or nursing women, and people with severe liver or kidney disease.

Combination With Other Supplements

  • Celadrin and glucosamine may work together to block the clumping of platelets and reduce blood clotting [1].
  • Celadrin and creatine bind to each other to enter the bloodstream more easily. This helps to deliver creatine to joints and reduce inflammation [7].

User Experiences

Many users like that the Celadrin cream is not greasy, absorbs easily into the skin and is as effective as painkiller pillsMany use it to treat lower back, shoulder, and knee pain.

One user was very satisfied with Celadrin’s fast action and felt pain relief in the knee just 25 minutes after taking 2 capsules.

Another user took Celadrin for their extreme fibromyalgia pain. It reduced their joint pain and they could easily perform daily tasks that they couldn’t before, without experiencing any adverse side effects. They took 2 softgels 3 times a day, stating that this “attack dose” works well for the first week of using Celadrin.

A few users have experienced negative side effects. One felt drowsy, while others have experienced excessive sweating, muscle and chest pain, deep vein thrombosis, and trouble walking. This mainly occurred in older users.

Some users also experienced diarrhea and stomach cramps.

One user mentioned that using glucosamine and chondroitin along with Celadrin helped with their osteoarthritis.

Another user advises others to use Celadrin specifically if they have a pinched nerve or joint inflammation, as it greatly reduced the pressure on the nerve running down their arm.

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About the Author

Dhwani Korde

MS (Neuroscience)

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