Selank is a small protein produced in Russia to treat anxiety and improve learning. No side effects have been observed. Keep reading to learn more about the possible benefits of Selank.

Disclaimer: By writing this post, we are not recommending this drug. Some of our readers who were already taking the drug requested that we commission a post on it, and we are simply providing information that is available in the clinical and scientific literature.

What is Selank (TP-7)?

The recent boom in biotechnology has opened the door for studying new biologically active compounds, including nootropics. One of these is Selank (previously known as TP-7), which belongs to a class of molecules called synthetic peptides, or small artificially-made proteins [1].

It is an anti-anxiety compound that improves learning and increases energy without side effects or the risk of addiction.

Selank is small and only a fraction of the size of most naturally occurring proteins. It was derived by combining the sequence of a peptide called tuftsin with another sequence that improves its stability. Tuftsin is naturally occurring and makes up one part of IgG (an antibody) [2].

Rats were given tuftsin, and more recently Selank exhibited reduced anxiety and increased serotonin levels [3].

Selank (TP-7) Mechanism of Action

Selank stabilizes enkephalins in the blood. Enkephalins are natural peptides in the body that reduce stress [4, 5].

However, some mice did not demonstrate the enkephalin stabilization following dosing with Selank and did not benefit from its anti-anxiety effect [6].

In cells, Selank binds to GABA receptors. Most compounds that bind to GABA receptors cause a sedative effect. In mice treated with Selank, researchers discovered more activity in inhibitory neurons, which rely on GABA. This resulted in less brain activity [7, 8, 9].

In addition, researchers discovered an increase in BDNF, which has been implicated in learning and memory and may explain how Selank improves learning [10, 11].

Selank also changes levels of the neurotransmitters norepinephrine, dopamine, and serotonin. They are involved in motivation, focus, and pleasure [12].

In some mice, Selank increased norepinephrine, but decreased dopamine and serotonin. In other mice, Selank increased norepinephrine and dopamine and did not change serotonin [12]. Therefore, its exact effect/mechanism is not clear.

Possible Uses and Effects of Selank

1) May Improve Anxiety

In a study (randomized controlled trial) of 62 patients, those treated with Selank had fewer anxiety symptoms, with a greater decrease being observed in those suffering from pre-existing anxiety disorders [13].

In another study (randomized controlled trial), similar benefits were observed in 60 patients suffering from anxiety and phobias up to a week after the final dose [14].

Additionally, in 70 anxiety patients, Selank increased phenazepam’s effects (an anti-anxiety drug banned in some U.S. states for its recreational use) while reducing its side effects (drowsiness and memory loss) [15, 16].

In mice, Selank reduced their anxiety. The more anxious the mice were, to begin with, the more significant the result [17, 18].

Additionally, it showed anti-anxiety effects on rats over 4 weeks of daily treatment [19].

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2) May Assist with Learning

In rats, within three days, Selank supplementation improved learning ability [20].

The Selank-treated rats were able to learn more quickly during an electrical test. It also reduced their anxiety, which helped them move faster [21, 22].

4) May Help Recovery from Brain Damage

In one study, researchers gave Selank supplements to rats with toxin-induced brain damage. This drug restored their brain activity to normal levels [23].

5) May Enhance Memory

Selank stabilized memory traces (storage) in rats during a 30-day trial. However, it is unclear how these measurements were performed, as memory traces are not detectable as discrete locations in the brain [24, 25].

It may also preserve memories in monkeys [26].

6) May Strengthen Immune Function

Selank increased IL-6 in the blood of patients suffering from depression. IL-6 is an inflammatory protein that helps fight infection [27, 28].

In cell-based studies, Selank caused the release of interferons, which are anti-viral molecules [29].

Selank protects cells from some viral infections. However, mice infected with a virus did not benefit from Selank (no treatment effect) [29].

7) May Increase Antioxidant Activity in the Liver

Injection of Selank increased the levels of antioxidants in the livers of stressed mice [30].

8) May Improve Symptoms of Depression

Mice treated with antidepressants, such as lithium, move more when placed in a forced swimming container [R, R].

Low doses of Selank were more effective at decreasing depression symptoms than high doses [31].

9) May Decrease Blood Pressure and Increase Blood Flow to the Brain

In sedated cats, Selank decreased blood pressure by about 30% for 3 minutes [32].

It also increased blood flow to the cats’ brain by about 24% for up to 10 minutes. Sedation can affect blood pressure and brain blood flow [33].

10) May Reduce The Severity Of Alcohol Withdrawal

To mimic high alcohol intake, rats were given a 10% ethanol (alcohol) solution as their sole drinking source for 24 weeks. Selank decreased the anxiety of rats following 48-hour alcohol withdrawal [34].

11) May Help Prevent Weight Gain and Reduce Cholesterol

In one study, rats on a high-fat diet had 35% less weight gain when treated with Selank. Additionally, total cholesterol for these rats was reduced by over 58% and blood glucose level was reduced by 23.5% [35].

12) May Fight Cancer

In one study, mice with breast cancer were treated with daily doses of Selank and had slower tumor growth. Also, these mice lived longer [36].

13) May Reduce Inflammation in the Spleen

After treatment with Selank, mice spleen had increased levels of several inflammatory response genes, which may protect from the harmful effects of inflammation [37].

14) May Improve Ulcers

Selank reduced the area of stomach ulcers in animal models [38, 39].

This may be because this drug increases lymph flow, an important component of the immune system, to the stomach [40].

Selank, NA-Selank, and NA-Selank Amidate

Selank is sold in three forms. The commonly researched form is Selank. NA-Selank (also called N-Acetyl Selank) is the same as Selank but with an “acetyl” group attached to one end.

Acetyl groups may assist in penetration into the brain [41].

No human studies have been performed on NA-Selank.

Amidate (also known as Etomidate) is a sedative used for general anesthesia [42].

There are no available studies that combine Selank with Amidate.

Selank vs. Semax

Much like Selank, Semax is also a synthetic peptide.

Semax comes from a different protein (a brain hormone) and also has different purposes, such as improving circulation and preventing liver damage.

Things to Know About Using Selank

Dosage of Selank

Selank products are normally available as a 0.15% spray, with 75 μg of Selank per spray. The recommended dosage is 2 or 3 sprays per dose with 3 doses per day (a max total of 675 μg/day) [43].

For an adult weighing 67.5 kg (about 149 lbs.), this translates to about 0.01 mg Selank/kg body weight. Rat studies normally used 0.3 mg/kg body weight.

Limitations and Caveats

In sum, the above data seems encouraging, but there is room for skepticism about the future of Selank.

Firstly, despite the stabilizing protein sequence, the half-life of Selank is only two minutes. Selank is undetectable in the blood after 10 minutes [44, 45].

This puts into doubt whether it can really have the week-long effects as reported in the clinical trials.

There is limited information about Selank’s activity in patients because there are only 3 clinical studies listed in PubMed [46].

Another concern is the lack of reported side effects. Many of the studies conducted were very short-term (within 24 hours). More rigorous and longer testing must be performed to measure side effects.

One final concern is that Selank cannot be taken orally because the stomach will digest it. Thus, you must either inject it under the skin or inhale it through the nose, with inhaling being more effective in delivery to the brain [47].

This dosing requirement may be off-putting to some considering trying this drug.

While Selank is purchasable in Russia, it still has a long road ahead before it becomes readily available in the US. Synthetic peptides require FDA approval in the US.

The Russian Academy of Sciences reported all findings described above. As the Russian Academy of Sciences is the sole developer of Selank, there is a conflict of interest in these studies.

User Reviews

Users reported that Selank has anti-anxiety effects at higher doses. However, they did not experience any nootropic (brain or memory-enhancing) effects.

Buying Selank

Selank is available online. Use the coupon code selfhacked8 for 8% off.

This drug has not been evaluated nor used in the US.

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