Vitamin B5 is an important supplement that helps maintain bodily function and metabolism. It is a natural substance that can improve your health. Read below to learn about the health benefits that Vitamin B5 provides.

What is Vitamin B5 (Pantothenic Acid)?

Vitamin B5, or pantothenic acid, is involved in many different functions of the body. It helps convert food into energy and it also helps the body use proteins and fats. Vitamin B5 important for the immune, nervous, and gastrointestinal systems.

It is a precursor for coenzyme A (CoA), which many different enzymatic pathways in the body need. Its minimal side effects make it a good therapeutic agent for many diseases [R].

Vitamin B5 is sold under many different names as supplements: D-pantothenic acid, dexpanthenol, zinc pantothenate, and calcium pantothenate [R].

Vitamin B5 Snapshot


  • Helps with immune and nervous system function
  • Aids metabolism of fats and carbohydrates
  • Balances cholesterol levels
  • Reduces stress


  • Side effects include fatigue, headache, nausea, depression
  • High dosage can cause digestive problems and diarrhea

Health Benefits of Vitamin B5

1) Pantothenic Acid is an Anti-Inflammatory

Adrenal glands need CoA (and Panthothenic Acid) to produce cortisol. Cortisol is an important anti-inflammatory produced by the body.

Moreover, it suppresses the immune system and aids in fat, protein, and carbohydrate metabolism [R].

Several animal experiments recorded that a lack of vitamin B5 can affect the adrenal cortex to function properly.

2) Pantothenic acid Aids in Metabolism and is Needed for Bodily Function

Red blood cells need calcium pantothenate to be manufactured and it is also needed to help produce sex and steroid hormones [R].

It is also important in maintaining a healthy digestive tract and helps with the usage of other vitamins.

Vitamin B5  (D-Pantothenic acid) helps with the synthesis of essential lipids and neurotransmitters.

Since it is a precursor to coenzyme A, it is essential for the metabolism of lipids and carbohydrates [R].

3) Pantothenic Acid Helps Reduce Stress

Based on human and animal research it appears that coenzyme forms of Pantothenic acid may allow individuals to sustain adaptive response and minimize some of the systemic effects of stress [R].

Adrenal glands need pantothenic acid to make high levels of CoA. These glands make the hormone corticosterone.

This hormone is known to respond to the many kinds of stress. However, the reason that vitamin B5 may relieve stress during tests is still under research [R].

4) Pantothenic Acid Promotes Heart Health

By converting carbohydrates and fats into glucose,  D-Pantothenic Acid helps balance and lower cholesterol levels in the body. It may also help to lower high blood pressure and prevent heart failure [R].

According to a triple-blinded placebo and diet controlled investigation Pantethine (a derivative of Vitamin B5) favorably altered total, LDL (low-density lipoprotein) and non-HDL (high-density lipoprotein) cholesterol in low to moderate cardiovascular risk participants [R].

Pantothenic acid was effective in treating a young boy with dilated cardiomyopathy (diseases of the heart muscle) according to one clinical report. Large doses of pantothenic acid produced a sustained improvement in myocardial function and growth [R].

In one clinical study, Pantothenic acid drugs (calciipantothenas and pantethine) were effective in treating patients with coronary heart disease and stable angina of effort [R].

5) Pantothenic Acid is Essential for Liver Function

The liver has high concentrations of CoA (Pantothenic acid makes up CoA).

High concentration of CoA in the liver helps the body to get rid of the toxic substances we are exposed to, thus helping liver function properly [R].

6) Pantothenic Acid Helps Prevent Hair Loss

In a double-blind placebo-controlled clinical study Pantothenic acid (as a component of Pantogar) proved to be effective than the placebo in improving the quality of hair and retarded hair loss [R].

In another study panthenol (alcohol analog of Vitamin B5) along with caffeine, niacinamide, dimethicone and an acrylate polymer (CNPDA) significantly increased the diameter of scalp hair fibers, decreased shear modulus (increased suppleness/pliability) and increased break stress (ability to withstand force without breaking) [R].

7) Pantothenic Acid Helps Treat Respiratory Problems

Pantothenic acid in the form of Dexpanthenol in “ Myer’s Cocktail” (Magnesium, Calcium, B vitamins and Vitamin C), when supplied to a five-year-old boy with a 2-year history of Asthma, showed a marked improvement and prevented further asthma attacks [R, R].

In another clinical case study of a 40-year old male presented with cold and a one-day history of nasal congestion and rhinorrhea (condition in which the nasal cavity is filled with a significant amount of mucous fluid) when given an oral infusion of 1 ml Vitamin B5 along with other components of the Myer’s cocktail was symptom-free by the end of the 10-minute treatment [R, R].

According to a pilot study in children with allergic rhinitis, a medical device grip-stop DMG with D-panthenol (also included lactoferrin, carboxymethyl -glucan and dipotassiumglycyrrhizinate) effectively reduced all considered symptoms of allergic rhinitis including nasal congestion [R].

Thus Pantothenic acid along with the other minerals and vitamins was effective against asthmatic bronchitis [R, R], upper respiratory tract infections, chronic sinusitis, and seasonal allergic rhinitis.

8) Dexpanthenol Can Reduce Pain in Eyes

Eye drops use Vitamin B5, in the form of dexpanthenol, to help reduce pain and inflammation in dry eyes (R).

9) Vitamin B5 Helps Keep Skin Healthy

D-Pantothenic acid helps to keep skin healthy and has a moisturizing effect [R].

Acne might be caused by a pantothenic acid deficiency [R].

Calcium pantothenate speeds up the wound healing process in the test tube and animal experiments by repairing the skin and is most effective when a subject is recovering from surgery [R].

Sources of Vitamin B5

Vitamin B5 is found in different foods like Meat (beef, fish, lobster pork, chicken), sunflower seeds, dairy products (yogurt, milk, cheese, etc) eggs, avocado, sweet potato [R].

Bacteria in the large intestine can naturally produce calcium pantothenate. Human breast milk also contains pantothenic acid [R, R].

Side Effects

Symptoms like fatigue, headaches, nausea, tingling in the hands, depression, personality changes and heart instability have been reported as side-effects after taking vitamin B5 supplements.

Additionally, high dosages can lead to digestive problems, abnormal teeth sensitivity, and diarrhea.

Vitamin B5 deficiency is uncommon in humans. However, some common symptoms include numbness and burning sensations in the limbs, headaches, fatigue, and insomnia [R].


The following doses are recommended daily: [R]

  • 1.7 mg for infants younger than six months
  • 1.8 mg for infants 6-12 months
  • 2 mg for children 1-3 years
  • 3 mg for children 4-8 years
  • 4 mg for children 9-13 years
  • 5 mg for 14 years and older
  • 6 mg for Pregnant women
  • 7 mg for Breastfeeding women

Technical Information

  • Pantethine, the stable disulfide form of pantetheine, is the major precursor of coenzyme A, which plays a central role in the metabolism of lipids and carbohydrates. Additionally, Pantethine has beneficial effects in vascular disease, is able to decrease the hyperlipidemia, moderate the platelet function and prevent the lipid peroxidation [R].
  • Researchers observed a strong stimulatory effect of pantothenate at a concentration of 20 micro gm/ml on the proliferation of cultivated dermal fibroblasts.  Functional studies revealed the enhanced suppression of free radical formation in skin fibroblasts cultured with panthenol [R].
  • Pantethine demonstrated significant (P < .005) and sustained reductions (from baseline to week 16) in TC (6 mg/dL, 0.16 mmol/L, 3%), LDL-C (4 mg/dL, 0.10 mmol/L, 4%), and apolipoprotein B (4 mg/dL, 0.04 g/L, 5%). Our data suggest that pantethine supplementation for 16 weeks (600 mg/d for weeks 1-8 then 900 mg/d for weeks 9-16) is safe and significantly lowers TC and LDL-C over and above the effect of TLC diet alone [R].

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