Boswellia is a great anti-inflammatory and I like to use it to tame the immune system.  It’s a versatile supplement and can accomplish many things.  Good for Th1 dominant.

071121_boswellia

Introduction

Boswellia resins, also known as frankincense/olibanum, are obtained from Boswellia trees. Incisions are made in the trunks of the trees to produce exuded gum, which appears as milk like resin, and hardens into orange-brown gum resin (R,R).

There are many Boswellia species and varieties, including Boswellia sacra from Oman and Yemen, Boswellia carteri from East Africa and China, Boswellia frereana from Somalia and Boswellia serrata from India (R,R).

Today the most traded frankincense is produced in Oman, Yemen, and Somalia (R).

Boswellia resins have been considered throughout the ages to have a wealth of healing properties (R).

Since ancient times, frankincense has been used in Africa, China, India, and the Middle East for the prevention and treatment of various illnesses, especially chronic inflammatory diseases (R).

Boswellia resins have been traditionally used to treat rheumatoid arthritis and other inflammatory diseases such as Crohn’s disease (R).

Boswellia serrata is one of the ancient and most valued herbs in Ayurveda (R), and in the Indian system of medicine, frankincense has been used as an anti-inflammatory, anti-arthritic, anti-proliferative, and analgesic agent for the treatment.

In Traditional Chinese Medicine, frankincense of B. carterii is commonly used as a remedy for improving the blood circulation and in relieving pain (R).

Boswellic acids have been identified as the major chemical components in Boswellia extracts that provide anti-inflammatory activity (R).

Modern medicine and pharmacology strongly support Boswellia’s anti-arthritic, anti-inflammatory, blood-lipid-regulating, anti-atherosclerotic, pain-relieving and liver-protecting properties (R).

Boswellia has anti-inflammatory activity, due to the ability to regulating immune cytokine production and leukocyte infiltration (R).

Extracts from Boswellia have further been shown to possess anti-bacterial, anti-fungal, anti-carcinogenic, and anti-neoplastic properties (R).

Boswellia acids provide anti-neoploastic activity through their anti-proliferative and cell-death-inducing properties in multiple human cancer cell lines, including meningioma cells, leukemia cells, hepatoma cells, melanoma cells, fibrosarcoma cells, colon cancer cells, and prostate cancer cells (R).

Boswellia resin additionally has an analgesic and tranquilizing effects (R,R).

Inhalation and consumption of Boswellia reduces the risk of asthma (R).

Boswellia resins attenuate memory deficits (R).

My Experience With Boswellia

In short, I really enjoy the anti-inflammatory effect from boswellia.  It’s a good supplement for Th1 dominant people such as myself.

The Boswellia That I Take

Below, I give a few different options to buy Boswellia, but some people want to to know which one I recommend.

Boswellia Snapshot

  • Longevity8.5/10
  • Inflammation9.5/10
  • Mood8.5/10
  • Cognition8.0/10
  • Energy8.0/10

Pros

  • Great anti-inflammatory and combats autoimmune disease
  • Protects gut
  • Good for mood and cognition
  • Great for Th1 dominant
  • Diversely beneficial supplement
  • Anti-microbial
  • Boosts fertility
  • Anti-cancer

Cons

  • I have not come across any negatives

The Health Benefits of Boswellia

1) Boswellia Protects the GI Tract

Boswellia has wound-healing, anti-ulcer, and anti-diarrheal properties (R,R).

Boswellia serrata oleo-gum extract (BSE), has antioxidant activity and protects the intestinal epithelial barrier from inflammatory damage (R).

Boswellia serrata was effective in the treatment of chronic colitis with minimal side effects (R).

Boswellia serrata gum resin improved ulcerative colitis in patients with 80-82% remission (R,R).

In rats, Boswellia serrata showed anti-inflammatory and antioxidant effects, inhibiting inflammation in acute colitis (R).

Boswellia serrata gum resin extract (BSE) prevents diarrhea and normalizes intestinal motility in rodents, without slowing the rate of transit in control animals (R).

Oral therapy with Boswellia extract significantly attenuated gastrointestinal ileum injury in rats (R).

One study showed no superiority of Boswellia versus placebo in patients with Crohn’s disease (R).

2) Boswellia is Beneficial in Asthma

Frankincense has traditionally been valued for its effect on the respiratory system, and has been used in steam inhalations, baths, and massages to treat cough, catarrh, bronchitis, and asthma (R).

Boswellic acids found in frankincense have shown to be responsible for the inhibition of leukotriene biosynthesis and, therefore, can reduce and prevent the inflammation in many chronic inflammatory diseases like asthma (R).

Gum resin of Boswellia serrata improved bronchial asthma in 70% of patients, as evident by disappearance of physical symptoms and signs such as difficulty in breathing, hissing lung sound and the number of attacks (R).

3) Boswellia Improves Cognitive Functions

Boswellia is traditionally believed to improve learning and memory (R).

Young rats whose mothers were treated with Boswellia in pregnancy showed increase in the power of learning, short-term and long-term memory, and an increase in the volume of hippocampal neurons, and the number of synaptic connections (R).

In a temporal lobe epilepsy rat model, Boswellia extract improved learning ability and eliminated the adverse effects of seizures on cognitive function (R).

Boswellia papyrifera showed significant improvement in visuospatial memory in multiple sclerosis (MS) patients (R).

Boswellia serrata enhanced cognitive outcomes in patients with diffuse axonal injury (R).

In traumatic brain injury mouse model, incensole acetate (IA) isolated from Boswellia resin inhibited hippocampal neurodegeneration and exerted a beneficial effect on cognitive ability (R).

Incesole acetate also protected against ischemic neuronal damage and reperfusion injury in mice (R).

4) Boswellia Combats Headaches

Oral Boswellia serrata reduces the intensity and frequency of headaches in patients with CCH (chronic cluster headache) (R).

5) Boswellia could be Beneficial in Anxiety and Depression

Incensole acetate (IA), a Boswellia resin constituent causes anxiolytic-like and antidepressive-like behavioral in mice (R,R).

Incensole acetate (IA), exhibits an anti-depressive-like effect in mice following a single dose administration (R).

6) Boswellia Reduces Inflammation

http://pubs.rsc.org/en/content/articlelanding/2012/np/c2np20060k#!divAbstract

http://pubs.rsc.org/en/content/articlelanding/2012/np/c2np20060k#!divAbstract

A mixture of Boswellic acids reduced increase lymphocyte proliferation, whereas higher concentrations were inhibitory (R).

Boswellic acids increase phagocytosis of macrophages (R).

Boswellic acids affect the cellular defense system by inhibiting the production/release of cytokines (R).

Boswellia has shown to be a specific inhibitor of leukotrienes, inhibiting inflammation and shrinking the inflamed tissue which is the primary cause of pain and discomfort in many cases (R).

Clinical studies show efficacy in treating autoimmune diseases including rheumatoid arthritis, Crohn’s disease, ulcerative colitis and bronchial asthma. Side effects are not severe when compared to modern drugs used for the treatment of these diseases (R).

7) Boswellia Relieves Rheumatoid Arthritis

Boswellic acids exhibited 25-46% inhibition of edema in rats and mice and exhibited 45-67% anti-arthritic activity in animal models (R).

Oral administration of Boswellia serrata gum resin extract (BSE) resulted in significantly reduced levels of inflammatory mediators in rats with rheumatoid arthritis (R).

Clinical trials of gum-resin of Boswellia showed improvement of symptoms in patients with osteoarthritis, and rheumatoid arthritis (R).

All patients with osteoarthritis of the knee receiving Boswellia reported a decrease in knee pain, increased knee flexion and increased walking distance (R,R).

8) Boswellia is Good for Gums

Plaque-induced gingivitis showed improvement of inflammation after using the extract and powder of frankincense (R,R).

9) Boswellia Reduces Breast Tissue Density

Boswellic acid inhibits inflammation and exerts a protective effects on breasts. In combination boswellic acid, betaine and myo-inositol significantly reduced breast density (R).

Boswellic acid, betaine, and myoinositol, further reduced breast pain, and reduced benign breast tumor dimension (R).

Boswellia reduces fibroadenoma (benign breast tumor) volume and dimension with no relevant side effects (R).

10) Boswellia Protects the Liver

Boswellia serrata extract had protective properties in animal liver (R).

Non-alcoholic fatty liver disease (NAFLD) rats treated with boswellic acids showed improved insulin sensitivity and a reduction in liver index and activities of liver enzymes (R).

In chronic hepatitis-associated fibrosis in mice the combined oral administration of Boswellia and Salvia extracts improved the course of the disease (R).

Parazite Schistosome eggs induce liver granulomatous inflammation, and Boswellia extract can significantly attenuate Schistosome  japonicum egg-induced hepatic granuloma (R).

11) Boswellia Relieves Pain

Boswellia sacra has analgesic properties (R).

Boswellia serrata significantly increased the pain threshold and pain tolerance in humans (R).

12) Boswellia Combats Cancer

AKBA-2

Boswellic acids are potent cell-death causing agents to cancer cells (R).

Boswellia reduces cell viability and induces cell death in human breast cancer cells, bladder cancer cells, pancreatic cancer cells, hepatocellular carcinoma and colorectal cancer cells, myeloid leukemia cells, neuroblastoma cells and meningioma (R,R,R,R,R,R,R,R,R,R,R,R,R).

In mice, Boswellic acid by oral application prevented intestinal tumorigenesis more potently than aspirin (R).

Oral administration of Boswellic acid inhibited the growth of colorectal cancer tumors in mice (R).

Boswellic acid inhibited gastric carcinoma growth in mice (R).

Administration of Boswellic asid significantly inhibited ascitic and solid Ehrlich tumor growth in mice (R).

Boswellic acid was highly effective in suppressing tumor growth and metastasis in mice (R).

Boswellia serrata inhibited pancreatic cancer cell and breast tumor cell  invasion and metastasis (R).

13) Boswellia Reduces Brain Swelling

An ethanolic extract of the gum resin of Boswellia serrata reduced peritumoral brain edema by 22-48% (R).

In patients with malignant glioma, administering 3600 mg/day of Boswellia extract (60% boswellic acids), 7 days prior to surgery, caused decrease in the fluid around the tumor to an average of 30% in 8 of the 12 patients and the signs of brain damage further decreased during the treatment (R).

Boswellia serrata reduced radiotherapy-related edema in 60% of patients (R).

14) Boswellia is Cardioprotective

Boswellia carteri exhibited mild cardioprotective effect and weak antioxidant activity in animals with a heart attack (R).

Boswellia has blood thinning activity in rats (R,R).

β-boswellic acid (β-BA) ameliorates plasma coagulation parameters and protects blood vessels from injury (R).

15) Boswellia is Beneficial in Diabetes

Oral administration of Boswellia glabra leaf and root extract decreased the blood glucose level in diabetic patients. Continuous use decreased blood glucose, cholesterol, triglyceride, urea, and creatinine levels and enzyme activities (R).

Administration of Boswellia serrata in diabetic rats significantly decreased the level of blood glucose, and prevented complications of diabetes in the kidneys and liver (R).

Boswellia extract prevented the increase of blood glucose levels, prevented pancreatic islet destruction and consequent hyperglycemia in an animal model of type 1 diabetes (R).

Boswellia serrata significantly increased blood HDL levels, remarkably decreased cholesterol, LDL, fructosamine SGPT and SGOT levels after 6 weeks  in diabetic patients(R).

16) Boswellia has Anti-Obesity Properties

Boswellia extract in mice reduced the accumulation of fat under the abdomen (R).

17) Boswellia is Good for the Skin

Use of a cream containing Boswellic acids on facial skin lead to significant improvement in photoaging, tactile roughness, and fine lines, increased elasticity, and decreased sebum excretion (R).

Boswellia serrata extract has a soothing effect on irritated skin, reduces redness and irritation and produces an even skin tone (R).

Boswellic acid (AKBA) is an effective topical agent to soften facial lines and relax the skin (R).

Patients with psoriasis, scales and erythema improved both with a cream containing Boswellic acids (R).

In a routine toxicity studym Boswellia resin and AKBA showed moderate to low toxicity on the skin (R).

18) Boswellia Boosts the Immune System

Boswellia serrata fraction enhances macrophage activation (R).

19) Boswellia Combats Pathogens

Boswellia carterii and Boswelli adalziellii showed antimicrobial activity against various microorganisms such as fungi, gram-positive and gram-negative bacterial strains (R,R).

Boswellia Combats Viruses

Boswellia serrata gum resin showed antiviral activity against the mosquito-transmitted chikungunya virus (CHIKV) and vesicular stomatitis virus in the laboratory (R).

Boswellia Combats Bacteria

Boswellic acid (AKBA) prevents as well as reduces the biofilm generation by Staphylococcus aureus and Staphylococcus epidermidis (R).

AKBA exhibited an inhibitory effect on various oral cavity pathogens tested (R).

Boswellia Combats Protozoans

Boswellia diterpenes were found active against sleeping sickness inducing Trypanosoma brucei and malaria inducing Plasmodium falciparum (R).

Boswellia Combats Fungi

Boswellia carteri and Boswellia papyrifera combat fungi. Boswellia rivaehas showed the best activity against Candida albicans (R).

20) Boswellia May Boost Male Fertility

Oral administration of frankincense increased both sperm motility and sperm density in adult male rats, boosting fertility, and increasing the number of implantations and viable fetuses in females (R).

However, in a different study, it was shown that Boswellia smoke decreases FSH, LH and testosterone, decreases sperm count, motility and speed, and increases sperm anomalies (R, R). However, it can be argued that these effects come from the chemicals found in the smoke, and not from the plant itself.

Buying & Recommended Dosage 

Boswellia is generally taken as a capsule, tablet or its bark decoction orally (R).

Chemical constituents of Boswellia essential oils differ significantly due to the differences in climate, time of harvest, storage conditions, geographical source of resins, and methods of preparation (R).

The main component of frankincense is oil (60%). It contains mono- (13%) and diterpenes (40%) as well as ethyl acetate (21.4%), octyl acetate (13.4%) and methylanisole (7.6%) (R).

The suggested dosage for inflammatory or asthmatic conditions is 300-400 mg of the standardized extract (containing 60% boswellic acids) three times daily (R).

Boswellia Brands

Side Effects of Boswellia

Frankincense has not shown any severe side effect and is considered to be safe (R).

The anti-inflammatory effects of Boswellia, unlike many anti-inflammatory chemical drugs, do not cause any adverse effects on blood pressure, heart rate, respiration, or other autonomic responses, and the resin has remarkably low toxicity (R).

The gum resin of Boswellia is included in the list of safe substances and its use is permitted by US Food and Drug Administration (USFDA) as a food additive (R).

A repeated dose oral (90 days) toxicity study of Boswellia serrata was carried out in rats, and Boswellia was relatively safe up to the dose of 500 – 1000 mg/kg. No adverse impact on health was observed (R,R).

Bioavailability of Boswellia

Several studies note that Boswellia has very poor bioavailability and absorption (R,R,R).

Plasma levels of boswellic acids became only detectable when administered with a high-fat meal (R).

Technical

Ethanol extract of Boswellia carteri resin comprises 7 boswellic acids (R).

The four major boswellic acids found in frankincense are: β-boswellic acid (BA), acetyl-β-boswellic acid (ABA), 11-keto-β-boswellic acid (KBA), and 3-O-acetyl-11-keto-β-boswellic acid (AKBA), which are responsible for the inhibition of pro-inflammatory enzymes (R).

11-keto-β-boswellic acid is the most potent anti-inflammatory component of the resin, and selectively blocks leukotriene biosynthesis through inhibiting 5-lipoxygenase activity (R).

AKBA has shown to be effective against a large number of inflammatory diseases such as arthritis, bronchial asthma, chronic colitis, ulcerative colitis (UC), Crohn’s disease (CD), and cancer (R).

Besides boswellic acids, additional triterpene acids (i.e., tircuallic, lupeolic, and roburic acids) isolated from frankincense have anti-inflammatory potential (R).

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1 COMMENT

  • Jon

    Does Boswellia have immune stimulating polysaccharides?

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