Bromantane (Ladasten) is a drug that purportedly improves mental and physical performance. It may help relieve fatigue and anxiety, improve learning, and help with physical activity. However, there are a few side effects associated with this drug, and there are not many human studies available. Keep reading to learn all about bromantane’s positives and negatives.

What Is Bromantane?

Bromantane/bromantan (Ladasten) is a drug developed in Russia in the 1980s; it is a derivative of adamantane. It is an actoprotector, which is a kind of drug that enhances physical activity under extreme environmental conditions (low oxygen, high temperature, etc.) [1, 2].

Bromantane purportedly increases energy, reduces anxiety, inhibits fatigue, promotes learning, and improves movement coordination. All of these effects combine to help increase both mental and physical performance [2].

It does not possess any addictive potential and has no serious side effects [2].

However, it is banned from many sports competitions, including the Olympics [3].

Mechanism of Action

Although bromantane’s exact mechanism is unknown, scientists think that bromantane works by increasing brain activity (in the hippocampus, hypothalamus nuclei, and the reticular nuclei of the operculum) [4].

It acts through the dopamine system, by increasing tyrosine hydroxylase and amino acid decarboxylase. This, in turn, increases dopamine formation (synthesis) from tyrosine [5, 6, 7].

By increasing dopamine, bromantane increases alertness and wakefulness [8, 7].

Bromantane also increases serotonin in the brain, which helps increase feelings of happiness [9].


There is no evidence of bromantane’s effects on human genes.

In rats, bromantane administration to rats increased [10]:

  • HIF1A, which helps the body adapt to low oxygen levels.
  • ADRl (alcohol dehydrogenase), which helps with alcohol recovery.
  • SAA, which controls amyloid beta precursor protein. This protein is associated with increased Alzheimer’s disease risk [10, 11].

Uses of Bromantane

1) Improves Brain Function

In a study of 10 healthy subjects, bromantane improved productivity, vigilance, and motor performance (movement and coordination) [12].

Multiple clinical trials also showed that bromantane reduced anxiety [13, 14, 15].

By increasing dopamine and serotonin in rat brains, bromantane increased alertness and wakefulness [9, 16].

In another rat study, bromantane improved short-term memory, motivation, planning abilities, and attention [2].

In rats, bromantane enhanced brain activity. However, with toxic doses, it inhibits acetylcholine pathways [17, 18].

Bromantane given to female rats also benefited their offspring in a different rat study. The infant rats developed reflexes faster than other rats, but their growth development differences were insignificant [1].

2) May Improve Physical Activity

In rats, bromantane slightly increased adrenaline and noradrenaline’s effects. It kept adrenaline and noradrenaline in the blood instead of exiting the body via urine, thus helping with physical activity [19].

Rats performed more efficiently during swimming and treadmills tests when given bromantane [20].

Bromantane also increased the blood pumped by the hearts of rats [19].

3) May Reduce Inflammation

In mice, bromantane reduced depression-caused inflammation. It decreased the levels of the following inflammatory cytokines [21, 22]:

4) May Improve Neurasthenia

Neurasthenia is a condition characterized by fatigue, headache, mental weariness, and insomnia.

In a month-long study of 728 asthenia patients, 50 and 100 mg doses of bromantane helped reduce neurasthenia symptoms and improved their sleep. It also improved the patients’ quality of life, and only 3% of the patients experienced minor side effects [15].

In another month-long study of neurasthenia patients, bromantane reduced their symptoms [13].

Additionally, in another study of neurasthenia patients, bromantane affected their brain waves according to their brain activity levels. People with high alpha waves had increased low-beta waves and decreased high-beta waves, and vice versa in people with low alpha waves [23].

This suggests that if you are drowsy, bromantane wakes you up, and if you are awake, bromantane increases consciousness [23].

5) May Increase Immunity

In rats, bromantane helped stimulate the immune system during stressful conditions. It enhanced their resistance to toxic agents. Bromantane also increased immune cells (B-cell levels). This can help during fatigue recovery, high environmental temperature, and low oxygen conditions [24].

6) May Help With Reproduction

In male mice, bromantane administration increased sperm count and sperm movement. It also helped reduce embryo loss in female mice [25].

Additionally, 3 days of bromantane treatment increased rats’ sex drive (desire for sexual activity). This dose-dependent effect may be caused by the increase in dopamine activity [26].

Supplementing with Bromantane


Since there is a lack of human studies, there is no known effective dosage.

According to user reviews, standard doses are 50 to 100 mg per day, although athletes might dose higher. Many users report negative effects after 3,000 mg.

Bromantane stays in the body for a long time, and can still be present in the blood 2 weeks after use [2, 3].

Other Effects

Bromantane reduced pain sensitivity in mice, but only at extremely high levels (300 to 600 mg/kg) [27].

Also, bromantane may stimulate cytochrome P-450 production, which helps with detoxifying the liver [2].

Side Effects and Risks

There are no withdrawal symptoms from bromantane, and it is not addictive [28].

In animals, high doses caused [27]:

  • Vomiting/regurgitation
  • Diarrhea
  • Increased urination

Additionally, users reported fatigue, depression, and brain fog.

Limitations and Caveats

Although the results from animal studies seem promising, not much scientific evidence is available about bromantane’s effects on humans. The few human clinical trials that are available are either funded by the drug company, written in Russian, or both.

More studies are required before using bromantane for any of its purported health effects.

User Reviews

One user said that after regularly dosing for a week, their motivation, energy levels, and pleasure increased. It helped with his low dopamine levels. It was not like other stimulants that have an instant effect but required repeated doses. However, he warned that users should measure the dosages accurately and to not overdose.

Another user said that it was the best nootropic they’ve tried, and it gave them plenty of energy to go throughout the day. Unfortunately, it gave them too much energy and made them barely able to fall asleep.

Others also praised its anti-anxiety and antidepressive effects.

Although there is no scientific evidence available, users claim that bromantane helps improve Alzheimer’s and ADHD symptoms.

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