Adrafinil is a drug that makes users feel awake and alert. It is a popular stimulant because it has few side effects and does not require a prescription in many countries. Continue reading to discover the uses of adrafinil and how it works.
Disclaimer: By writing this post, we are not recommending this drug. Some of our readers who were already taking the drug requested that we commission a post on it, and we are simply providing information that is available in the clinical and scientific literature. Please discuss your medications with your doctor.
What Is Adrafinil?
Adrafinil is a synthetic nootropic drug that promotes long-lasting mental arousal. Adrafinil is a non-amphetamine psychostimulant. It reduces drowsiness but does not increase heart rate or anxiety [R].
As a prodrug (an inactive drug that breaks down to the active drug) for the prescription stimulant modafinil, adrafinil becomes active by converting to modafinil in the body. Adrafinil’s effects and mechanisms are thus identical to modafinil’s [R].
Adrafinil was designed to treat narcolepsy and attention disorders in the elderly. It was sold in France under the name Olmifon but was discontinued in 2011. Adrafinil was discontinued because it was less potent than modafinil and required higher doses to achieve a similar effect [R].
The United States, Canada, and the UK consider adrafinil a dietary supplement rather than a prescription drug. The World Anti-Doping Agency banned adrafinil as a performance-enhancing substance [R].
Adrafinil is unscheduled in the United States, Canada, and the UK. This means it is neither approved nor controlled and does not require a prescription. However, adrafinil requires a prescription in Australia and Germany.
Adrafinil Mechanism of Action
Adrafinil is inactive in its initial form. It becomes active by converting to modafinil in the liver [R].
Only a small amount of adrafinil converts to modafinil, with the majority becoming inactive. Thus, greater amounts of adrafinil than modafinil are required to achieve a similar effect [R].
Adrafinil has a short biological half-life (the time it takes a substance to lose half of its biological activity) of 1 hour. It converts to modafinil, which has a 12 to 15-hour half-life. This means that the user will feel effects many hours after consumption [R].
In a study (randomized controlled trial) of 10 elderly patients, peak blood levels of adrafinil occurred 1 hour after consumption. Peak brain and behavioral effects occurred 2 hours after consumption [R].
Adrafinil produces its effects using the same mechanisms as modafinil. They include:
- Increasing dopamine [R, R, R, R, R, R, R, R].
- Increasing serotonin [R, R, R, R, R].
- Increasing norepinephrine [R, R, R].
- Increasing histamine release via orexin [R, R, R, R, R].
- Increasing glutamate and decreasing GABA [R, R, R, R, R, R].
Uses of Adrafinil
Because adrafinil becomes active by converting to modafinil, both drugs have similar effects. The following studies highlight the research conducted on adrafinil.
1) Improves Mental and Physical Function
Adrafinil improved slow thought and movement (psychomotor impairment) compared to an antidepressant (clomipramine) in a study of 70 depressed older adults [R].
Adrafinil increased participants’ ability to perform daily activities in a study (randomized controlled trial) of 548 older adults with attention and memory problems [R].
2) Improves Awareness and Focus
In multiple studies of 744 older adults (including 2 double-blind randomized controlled trials and 1 randomized controlled trial), adrafinil increased attention, concentration, and vigilance [R].
In a study (randomized controlled trial) of 10 elderly adults, adrafinil decreased brain waves associated with sleep (slow wave delta and theta wavelengths and increased brain waves associated with engagement in the present (alpha wavelengths) [R, R].
3) Reduces Depression Symptoms
In multiple studies (including 1 double-blind randomized controlled trial) of 471 adults, adrafinil lowered symptoms of depression [R].
Adrafinil reduced symptoms of depression similar to an antidepressant (clomipramine) in a study of 70 depressed patients. The group receiving clomipramine reported frequent side effects, but adrafinil was well-tolerated [R].
4) May Improve Memory
In studies of 951 older adults (including 1 double-blind randomized controlled trial and 1 randomized controlled trial), adrafinil reduced forgetfulness, and improved information recalls [R].
5) May Improve Reaction Time
In a study (double-blind randomized controlled study) of 48 elderly adults with attention and processing speed problems, adrafinil reduced reaction time on a psychological test [R].
6) May Improve Learning
7) May Increase Movement and Activity
Advantages of Adrafinil Over Other Stimulants
1) Produces Few Side Effects
2) Has Low Addiction Potential
Modafinil, the active product of adrafinil, was taken for 3 years without causing tolerance or dependence in a study of 42 participants with excessive sleepiness and narcolepsy [R].
Side Effects of Adrafinil
Adrafinil is well-tolerated in most studies. A small number of participants have noted increased stress and aggression, nausea, irregular heartbeat, mouth dryness, stomach pain, and skin irritation [R, R].
One participant developed abnormal facial movements after taking 900 mg/day of adrafinil for 10 months. This symptom did not improve after 4 months off adrafinil but subsided after dopamine-lowering medication [R].
Because adrafinil converts to modafinil in the liver, there is concern that it can elevate liver enzymes or cause liver damage. Human research does not support this claim, although there are few clinical studies of adrafinil [R].
Drug Interactions of Adrafinil
No other drug interactions are reported in the literature.
Forms and Dosage of Adrafinil
Only a small amount of adrafinil converts to modafinil, with the majority becoming inactive. Thus, adrafinil requires greater amounts than modafinil to achieve a similar effect.
Adrafinil comes in powder or tablets. The standard recommended dose is 600 to 1,200 mg. This was the suggested dose for the prescription drug Olmifon (300 mg adrafinil per tablet) to treat narcolepsy when it was available [R, R].
Limitations and Caveats
Research on adrafinil is limited; most has instead focused on modafinil. This is because modafinil is more potent and requires a lower dose to cause an effect.
Most of the human studies on adrafinil were conducted in elderly patients in France in the late 1980s and early 1990s. These results were published in French scientific journals, and are not available online.
They are summarized in a 1999 review article, which is cited in this post wherever references to those studies are made [R].
User Experiences with Adrafinil
Most users report improved attention, cognitive function, and mood with minimal to no side effects. Yet, like most drugs, not all experiences are the same.
One user took 50 mg of adrafinil for the first time and felt increased awareness, optimism, and ability to think and concentrate after 90 minutes. This user had a normal heartbeat and no anxiety, which was different than their prior experiences with amphetamines. They continued to feel the full effects of adrafinil 6 hours after consumption and did not note a crash like they previously had while using an amphetamine.
Another user took adrafinil once every few weeks, or whenever they needed to work long hours. They took 300 mg in the early morning, and felt alert and focused at 7 or 8 pm that night. No side effects were reported.
After experimenting multiple times with doses between 300 to 900 mg of adrafinil, another user found the drug not very effective. They only experienced stimulation for a few hours rather than all day, as opposed to other users. The user also reported feeling tired as the drug wore off.