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CYP17A1 is important for the production of steroid hormones, including testosterone and estrogen. Gene variants are associated with elevated blood pressure, heart disease, Alzheimer’s, and cancer risk. Read on to find out more about CYP17A1 function, gene variants, and factors that decrease its activity.
What is CYP17A1?
This enzyme is also known as 17,20 lyase. It is one of the cytochrome P450 monooxygenases (CYPs) (R).
CYPs eliminate toxins and drugs from the human body. However, some, like CYP17A1, are not involved in detoxification but in steroid hormone production.
This is an important enzyme in humans that produces:
- mineralocorticoids, which affect sodium and water balance in the kidney (R).
- glucocorticoids, which control the body’s response to stress (R).
- all androgens (R, R). It converts pregnenolone to dehydroepiandrosterone, which is converted to androstenedione, testosterone, and dihydrotestosterone (R).
The enzyme is also indirectly responsible for the levels of estrogens, because estrogens are produced from androgens.
CYP17A1 Gene Polymorphism
Mutations that result in CYP17A1 deficiency are extremely rare. Deficiency symptoms include hypertension (high blood pressure), hypokalemia (low potassium), blunted stress response, primary amenorrhea (absence of menstruation), and failure to develop sexual characteristics after puberty. The defects in sex steroid production impair fertility in both male and female patients when the deficiency is severe (R, R, R).
The C variant results in higher enzyme levels and possibly higher levels of sex steroids (R).
People with this variant may have a lower risk of endometrial (4 studies) (R) and pancreatic cancers (308 cases and 964 controls) (R), but a higher risk of breast (3,149 patients and 5,489 controls) (R) and prostate cancers (214 patients) (R).
Also, rs743572 C was associated with an increased risk of leiomyoma (fibroids) (149 subjects) (R).
Women with Down syndrome with this variant have an increased risk of developing Alzheimer’s disease (235 subjects) (R).
Female C/C carriers have an increased risk of heart disease (997 subjects) (R).
rs17115149 was significantly associated with male infertility (oligoasthenoteratozoospermia) (456 cases and 465 controls) (R). This is a condition that includes oligozoospermia (low sperm count), asthenozoospermia (poor sperm movement), and teratozoospermia (abnormal sperm shape), and is the most common cause of low male fertility.
T/T in rs10786712 is a protective marker for heart disease in men (997 subjects) (R).
T/T may also be protective against hypertension (high blood pressure) (1031 subjects) (R).
The A variant may increase the risk of high blood pressure (1031 subjects) (R).
Male adolescents with this variant developed high blood pressure in response to mental stress (1028 subjects) (R).
Three SNPs in CYP17A1 were associated with obesity, measured as BMI and fat mass (rs3740397, rs6163, and rs619824) (1873 subjects) (R).
These decrease CYP17A1:
- Resveratrol (R).
- Metformin (R).
- Orteronel (R), abiraterone, galeterone, activin A (R), and ketoconazole (R).
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