Every time you breathe out, you’re exhaling carbon dioxide that was made by your body. A delicate balance of carbon dioxide is important to maintain the pH of your blood and your oxygen levels. Find out what can make your carbon dioxide levels drop too low (known as hypocapnia) and why this can be dangerous.
What is Hypocapnia?
Hypocapnia occurs when the carbon dioxide level (CO2) in your blood becomes too low.
Why exactly is there CO2 in your blood and what does it do?
Your cells are constantly producing CO2 as a byproduct of burning fats and sugars for energy. This CO2 travels through your blood and into your lungs, where it is eventually exhaled whenever you breathe out .
When the concentration of CO2 in your blood becomes lower than normal, it is known as hypocapnia (or sometimes hypocarbia). This can be a problem because CO2 also helps regulate your breathing rate and the acid-base balance in your blood .
In this article, we’ll break down what causes hypocapnia, what symptoms you can expect, and ways you can avoid it.
Hypocapnia often leads to a condition called respiratory alkalosis; so much so that the two terms are sometimes used interchangeably. Respiratory alkalosis occurs when the CO2 level of the blood drops below normal and the pH of the blood becomes too high .
This happens because your body naturally tries to produce more CO2 when your levels are low. The body does this by joining bicarbonate (HCO3-) and hydrogen ions to create more CO2 molecules. The problem is that hydrogen ions determine blood pH; by using up hydrogen ions to create CO2, the pH of the blood increases and becomes basic .
Hypocapnia is diagnosed by checking the carbon dioxide level in your blood, usually by performing an arterial blood gas (ABG) test .
The ABG test measures the pressure exerted by the carbon dioxide in your arteries, which is expressed as pCO2. This test also measures the pressure of oxygen (pO2) and the pH of the blood, which help diagnose respiratory alkalosis .
Normally, your pCO2 should be between 35 – 45 mmHg. Levels below this indicate hypocapnia .
On the other hand, if your pCO2 levels are above normal, you may have a condition called hypercapnia (the opposite of hypocapnia).
Normally, your body maintains a balance between the steady amount of CO2 that is produced by burning calories and the CO2 you breathe out. Hypocapnia occurs when this balance is disrupted, which usually happens when the amount of CO2 you breathe out increases .
In almost all cases, hypocapnia is caused by rapid or deep breathing, also known as hyperventilation. During hyperventilation, more CO2 is exhaled from the lungs, which decreases the amount of CO2 in the blood .
Many conditions and factors that can increase your breathing rate and cause you to hyperventilate, including :
- Anxiety or panic disorder
- High altitudes
- Head injury
- Heart disorders, such as heart failure, low blood pressure, and blood clots
- Lung disorders, such as asthma and pneumonia
Certain medications are known to cause hyperventilation as well, including :
- Aspirin (when taken in excessive amounts)
- Methylxanthines, a class of compounds that include theophylline, caffeine, and theobromine
- Beta-agonists, a group of drugs used to treat asthma, COPD, and heart failure
- Progesterone, a hormone used to improve fertility and treat menopausal symptoms
Hypocapnia is well tolerated and the symptoms are usually mild. Some common symptoms include :
- Tingling sensations (“pins and needles”), usually in the limbs
- Abnormal heartbeat
- Muscle cramps
Seizures can occur in severe cases .
Hypocapnia causes respiratory alkalosis, when the pH of the blood becomes too high. Hyperventilation can also decrease the oxygen supply in the body. These two factors may do additional harm in severe cases .
The brain is especially sensitive to imbalances in blood pH and oxygen supply. Even very brief disruptions in oxygen supply can lead to permanent brain damage .
In adults, the effects of severe hypocapnia on the brain include :
- Worse reaction times
- Decreased cognition
- Slower movement
- Personality changes
Hypocapnia is also a great concern in newborns, especially premature infants. Studies show that severe hypocapnia (pCO2 < 15 mmHg) may impair the blood supply to the brain and deplete antioxidants, which can cause permanent brain damage in babies .
Hypocapnia not only decreases the oxygen supply of the body but also increases the body’s oxygen demand. This is because the heart has to work harder during hypocapnia and requires more oxygen. If the muscles in the heart don’t receive enough oxygen, they can become injured [2, 5].
When your CO2 levels are low, your body’s automatic response is to narrow the airways of your lungs, also known as bronchoconstriction. Your lungs also often stretch out more during hyperventilation. These two factors combined can lead to damage to the lungs .
People with asthma are especially vulnerable. Research shows that hypocapnia in asthma patients can reduce lung function, worsen symptoms, and lower quality of life .
Pregnant women naturally have pCO2 levels that are about 10 mmHg lower than nonpregnant women. However, if carbon dioxide levels in pregnant women drop further, there may be negative effects on the baby .
Two studies found that a brief drop in CO2 levels seen in mothers during a C-section may negatively affect the baby by decreasing oxygen levels and delaying the start of breathing. Administering CO2 may help prevent these effects [9, 10].
Another study in rabbits found that decreased CO2 levels in the fetus may impair lung development .
Treatment of Hypocapnia and Hyperventilation
What do you do when hyperventilating? A popular method is for someone who is hyperventilating to breathe into a paper bag. And it’s for a good reason: rebreathing into a paper bag increases your CO2 levels because you are re-inhaling the CO2 you exhaled .
However, rebreathing into a paper bag can also be dangerous, mainly because it reduces the amount of oxygen you are breathing in. For this reason, paper bag breathing is no longer recommended for hyperventilation or hypocapnia .
Instead, initial treatment of a hyperventilation episode usually involves using breathing techniques to slow down the breathing rate, such as counting between breaths or focusing on the second hand of a clock. The underlying cause of hyperventilation also needs to be addressed. Situational treatments for hyperventilation include [1, 13]:
- Anti-anxiety medications for anxiety-induced hyperventilation
- Antibiotics for patients with infections
- Ventilator support in severe cases
- Acidic agents for high blood pH
Ways to Avoid Hypocapnia
One of the best ways to prevent and treat episodes of hyperventilation is to employ breathing exercises to control the breathing rate. Some examples include :
- Diaphragmatic breathing, which focuses on using the diaphragm (a muscle in the lower part of the chest) to breathe into the belly
- Buteyko breathing, which focuses on nasal breathing and reducing breathing rate and depth
- Yogic breathing, which, generally speaking, uses various techniques and mental concentration to slow breathing
However, it’s not entirely clear how effective breathing exercises are for those who hyperventilate. A lack of research makes it difficult to say one way or another, but anecdotal evidence suggests breathing exercises are helpful for some .
More About Carbon Dioxide
For more information on carbon dioxide, check out our three-part series:
- What is Carbon Dioxide (CO2)? Blood Test & Normal Levels
- Causes & Health Risks of Low Carbon Dioxide (CO2) Levels
- Carbon Dioxide Poisoning & Causes of High CO2 in the Blood
Irregular CO2 Levels?
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Hypocapnia is when the carbon dioxide level in your blood drops below normal. Respiratory alkalosis, a condition where the pH of the blood becomes too high, is very closely linked to hypocapnia.
The most common cause of hypocapnia is hyperventilation, which causes more carbon dioxide to be exhaled out. Symptoms of hypocapnia are generally mild and may include tingling sensations, muscle cramps, and an abnormal heartbeat.
Breathing exercises are typically used to prevent and treat hyperventilation and hypocapnia, especially if the underlying cause is anxiety. Some examples include diaphragmatic breathing, Buteyko breathing, and yogic breathing.